Role of potassium channels in the development of hepatocellular carcinoma View Homepage


Ontology type: schema:MonetaryGrant     


Grant Info

YEARS

2013-2016

FUNDING AMOUNT

800000.0 CNY

ABSTRACT

Primary hepatocellular carcinoma (HCC) with a very poor prognosis is a common malignant tumor in our country. Membrane ion channels play an essential role in the maintenance of cell function. It has been shown that plasma membrane K+ channels are involved in fundamental cell behavior such as proliferation and apoptosis, indicating that K+ channels have a role in the development of cancer. However, the role of K+ channels in HCC remains unclear. Our preliminary study found the abnormal expressions of K+ channels , Eag1, Kv1.3 and Kca3.1, in HCC, indicating that the K+ channels may be involved in the development and progression of HCC. In the present study, we will further analyze the relationship between the abnormal expressions of K+ channels and clinico-pathological characteristics, recurrence and metastasis of HCC , explore the role of the K+ channels in the development and progression of HCC and reveal the cellular and molecular mechanism underlying. This project will contribute to providing a new target for the treatment of HCC and an important marker for the evaluation of prognosis of HCC. More... »

URL

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