Developing Breast Cancer Program at Xavier; Genomic and Proteomic Analysis of Signaling Pathways Involved in Xenohormone and MEK5 Regulation of ...


Ontology type: schema:MonetaryGrant     


Grant Info

YEARS

2002-2003

FUNDING AMOUNT

1676892 USD

ABSTRACT

PUBLIC ABSTRACT Breast cancer research needs to focus on developing breast cancer predictive models accurate for the disease among African-American women. HBCUs, like Xavier University (XU), are the best places to prepare future scientists and focus on the biology of breast cancer and its eradication in the African-American community. With the help of Tulane Cancer Center (TCC), XU will be able not only to build the necessary core of human talent to eradicate breast cancer in the African-American community but also to address important scientific problems like drug resistance and the effect of environmental agents on breast cancer. We have developed a four-part research and training program that will ensure significant results, develop independent breast cancer research program at XU, and train new faculty and African-American undergraduate students in breast cancer research. The funds will be used to support two research projects that will involve two faculty members of XU with mentors from TCC. This first part of the model will provide scientists funds to generate significant data about the molecular mechanisms of resistance and the molecular effect of environmental factors on breast cancer. Dr. Wang of XU will be mentored by Dr. Burow of TCC on a project designed to elucidate a previously unexplored cellular signaling mechanism that leads to drug resistance in breast carcinoma cells. An important aspect of this study will be the investigation of differences between breast cancer cells derived from African-American women and women of other ethnicities. Dr. Wiese of XU will be mentored by Dr. Hill on a project designed to identify and characterize the genes and gene products associated with abnormal pattern of growth that are induced by pesticides. This project is of great importance to women of African-American origin since the African-American community is primarily located in the South where the concentrations of pesticides is significantly higher than in other areas of the country. The project will focus on the effect of pesticides mixtures, as opposed to commonly investigated single pesticides, on breast cancer development and progression. The second part of the proposed program aims to increase the number of faculty at XU that are involved in breast cancer research. This will be accomplished by allocating funds to support two junior faculty members with little or no experience in breast cancer research to enable their participation in research activities in the area of breast cancer under a mentor from the TCC, as described above. The third objective of the program is to support research students from XU that will take part in all the activities of the partnership. The fourth objective of the project is to provide, through workshops, seminars, and research, XU faculty at large the opportunity to become familiar with topics in breast cancer and consider future participation in the center activities. The development of the proposed partnership between XU and TCC will greatly contribute to research efforts designed to better understand the unique aspects of breast cancer development and progression among African-American women. The involvement of African-American students in breast cancer research will increase the awareness of breast cancer in the African-American community and increase the likelihood of early detection of the disease. The research partnership between XU and TCC will contribute to the effort to eliminate the "mortality gap" between African-American patients with breast cancer and women of other ethnicities. The two institutions are within an easy five-minute drive from each other and have a strong and long history of collaboration that will promise success. More... »

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