The role of DGCR8 gene and miRNAs in the development of schizophrenia View Homepage


Ontology type: schema:MonetaryGrant     


Grant Info

YEARS

2011-2015

FUNDING AMOUNT

600000 CNY

ABSTRACT

Schizophrenia has a high prevalence, high morbidity, high recurrence rate, poor prognosis and other characteristics, seriously affecting China's population health and economic development. Cognitive impairment is one of the core symptoms of schizophrenia, and cognitive function is an important indicator of efficacy and social function prognosis. In the past, we have demonstrated that prenatal nutritional deficiencies have significantly increased the risk of schizophrenia after adulthood through a large sample of epidemiological surveys. We have induced famine pregnant women by low protein and calorie diets. , It is found that there are barriers to social contact behavior and spatial work learning and memory in adult rats with prenatal malnutrition. At present, Micro-PET / CT imaging is used to detect the changes of blood perfusion and glucose metabolism in different brain functional areas, and the changes of density, binding capacity and uptake ability of characteristic nerve receptors. Combining genetics / epigenetics / proteomics and / or transcriptional levels of experiments revealed the molecular mechanisms of postnatal malnutrition leading to cognitive impairment in adulthood, thus revealing the pathogenesis of schizophrenia, as well as prevention and control, early diagnosis And provide an important theoretical basis for treatment. More... »

URL

http://npd.nsfc.gov.cn/projectDetail.action?pid=31171237

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