Effect of tumor-specific promoter-regulated shRNA on tumor cell adenovirus on hepatocellular stem cell characteristics and targeted radiotherapy View Homepage


Ontology type: schema:MonetaryGrant     


Grant Info

YEARS

2011-2015

FUNDING AMOUNT

580000 CNY

ABSTRACT

Tumor stem cells are important causes of tumor resistance, metastasis, and radiotherapy and chemotherapy. In order to explore new therapeutic strategies for cancer stem cells, it is necessary to study and search for tumor stem cell-specific new targets that distinguish it from the normal tissue of the body. However, in the body or the same organization, tumor stem cells and normal stem cells have some similar phenotypes and regulatory mechanisms. Therefore, this subject on the basis of previous research to explore how to specifically for cancer stem cells themselves for effective imaging diagnosis and treatment, to avoid killing normal tissue cells and normal stem cells. Therefore, this subject uses oncolytic adenovirus to carry the target gene CD133-shRNA targeting tumor stem cells and protects the oncolytic adenovirus by using the tumor-specific promoter Survivin at the gene level to make it specifically distributed in the tumor tissue, Normal tissue to produce radiation damage, play the oncolytic adenovirus-mediated exogenous gene-specific expression and killing tumor cells two functions, to achieve its target treatment of liver cancer stem cells and increase radiotherapy sensitization. The expression of CD133 in the dry maintenance of hepatocellular carcinoma stem cells was also investigated by shRNA silencing or down-regulation of CD133 expression. More... »

URL

http://npd.nsfc.gov.cn/projectDetail.action?pid=81171365

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