Study on the Mechanism of "Health and Medicine" in "Bone Microdialysis - Pharmacokinetics / Pharmacodynamics" View Homepage


Ontology type: schema:MonetaryGrant     


Grant Info

YEARS

2011-2015

FUNDING AMOUNT

600000 CNY

ABSTRACT

Pay the Thai pill from the Ming o Han Mao "Han's Medical", the side of the effect of soothing berries and cinnamon, compatibility after the treatment of heart and kidney do not pay insomnia classic name side, and its "new health" Compatibility mechanism has been the confusion and focus of Chinese medicine research. On the basis of the preliminary research work of this project, the brain tissue and plasma microdialysis samples of the model animals were obtained by real-time online micro-dialysis-plasma synchronous sampling technique. The hypothalamic-pituitary-adrenal axis (HPA axis) (PD), and the concentration - time curve (PK) of the "active ingredient group" in plasma and brain tissue was also mapped to the quantitative effect of the monoamine neurotransmitter and the serum cytokine. Based on the theory of effect room model, the PK-PD synchronous analysis model was established to explore the dynamic changes of drug concentration-effect-time in brain tissue and systemic circulation, and to explore the blood-brain barrier permeability of "active ingredient group" "Compatibility of new students," the compatibility mechanism to reveal the best proportion of compatibility and its efficacy material basis for the classic name of the East to pay the pill to provide science, to develop based on "brain microdialysis - local pharmacokinetics / pharmacodynamics" study Traditional Chinese medicine central role in the efficacy of material basis and compatibility mechanism of new ideas, new ways. More... »

URL

http://npd.nsfc.gov.cn/projectDetail.action?pid=81173564

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