Manufacture of hepatocellular carcinoma stem cells with normal human hepatocytes View Homepage


Ontology type: schema:MonetaryGrant     


Grant Info

YEARS

2012-2015

FUNDING AMOUNT

600000 CNY

ABSTRACT

Tumor stem cells are involved in tumor recurrence or distant metastasis and tumor resistance to chemotherapy and radiotherapy. However, due to the heterogeneity of solid tumors, there is no reliable method for the isolation and identification of tumor stem cells. It has recently been reported that the introduction of a set of core nuclear programming factors allows reprogramming of somatic cells into induced pluripotent stem cells, while inactivation of the p53 tumor suppressor pathway facilitates this reprogramming process. In view of the similarity of gene expression and phenotypic characteristics of tumor cells and stem cells, we hypothesized that reprogramming of stem cells plays an important role in the development of tumors. We intend to combine somatic cell reprogramming with pluripotent stem cell passages to establish Normal hepatocytes to create hepatocellular stem cells, to determine the factors necessary for the creation of hepatocellular stem cells from normal hepatocytes, to reveal whether the nuclear reprogramming process plays an important role in the development of hepatocellular carcinoma and to screen for cell membrane markers that can be used for the identification of hepatocellular stem cells Material. More... »

URL

http://npd.nsfc.gov.cn/projectDetail.action?pid=81172066

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