Study on the correlation between tumor stem cells and heavy ion radiation View Homepage


Ontology type: schema:MonetaryGrant     


Grant Info

YEARS

2011-2015

FUNDING AMOUNT

600000 CNY

ABSTRACT

Tumor stem cells with high tumorigenicity, low radiation sensitivity and tolerance to chemotherapy drugs, a direct impact on cancer radiotherapy and chemotherapy efficacy. Tumor stem cells from the normal stem cells of the direct cancer or cancer cells in the process of cancer differentiation due to the differentiation of ancestors, there are still controversial. Heavy ion radiation is one of the important means of treating solid tumors. However, in the process of heavy ion treatment of cancer, it is unclear whether cancer cells and their adjacent normal tissue cells or normal stem cells can induce cancer to become cancerous stem cells. (IPS-S-01) and human lung adenocarcinoma cell A549 and normal human lung fibroblasts were irradiated with heavy ion (carbon ion) to select the survival of the human fetal fibroblast-derived stem cells (iPS-S-01) Cell monoclonal, related genetic instability and identification of stem cell surface markers. Assumed experimental imaging of putative stem cell lines, analysis of the potential and biological changes of tumor stem cells induced by heavy ion radiation, for heavy ion cancer The process of radiation hazards provides the right assessment and proper prevention. More... »

URL

http://npd.nsfc.gov.cn/projectDetail.action?pid=31170803

Related SciGraph Publications

  • 2014-03. Ionizing radiation induced biological effects in three-dimensional cell cultures in RENDICONTI LINCEI. SCIENZE FISICHE E NATURALI
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