Effects of Oxidative Stress on Hepatic Apoptosis in Liver Dairy Cow View Homepage


Ontology type: schema:MonetaryGrant     


Grant Info

YEARS

2012-2014

FUNDING AMOUNT

230000 CNY

ABSTRACT

Dairy cow ketosis is an important nutritional metabolic disease of perinatal dairy cows. The main pathologic features are hypoglycemia, hyperglycemia and hyperviscosity free fatty acid. This project to ketosis pathological hyperglycemia and hyperviscosity free fatty acid to weaken the ability of liver antioxidant and promote liver cell apoptosis, and then lead to liver "second strike" for the theoretical hypothesis. Using the methods of molecular biology, cell biology and biochemical detection, the antioxidant indexes (superoxide dismutase, glutathione, glutathione, glutathione, glutathione and glutathione peroxidase) were measured by in vivo (ketosis disease) and in vitro (primary hepatocyte) (P53, uncoupling protein 2, bcl-2, bax and caspase 3, etc.) as evidence of oxidative stress as a "secondary And the relationship between the signal pathway and the decoupling protein 2 on the oxidative stress and apoptosis of the liver. To confirm the presence of ketone dairy cows with hyperoxemia and hyperviscosity free fatty acid caused by oxidative stress in the liver and the liver damage caused by it, and to further reveal the pathogenesis of dairy cow disease and to find a new drug therapy target to provide the theory in accordance with. More... »

URL

http://npd.nsfc.gov.cn/projectDetail.action?pid=31101868

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/2206", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }
    ], 
    "amount": {
      "currency": "CNY", 
      "type": "MonetaryAmount", 
      "value": "230000"
    }, 
    "description": "Dairy cow ketosis is an important nutritional metabolic disease of perinatal dairy cows. The main pathologic features are hypoglycemia, hyperglycemia and hyperviscosity free fatty acid. This project to ketosis pathological hyperglycemia and hyperviscosity free fatty acid to weaken the ability of liver antioxidant and promote liver cell apoptosis, and then lead to liver \"second strike\" for the theoretical hypothesis. Using the methods of molecular biology, cell biology and biochemical detection, the antioxidant indexes (superoxide dismutase, glutathione, glutathione, glutathione, glutathione and glutathione peroxidase) were measured by in vivo (ketosis disease) and in vitro (primary hepatocyte) (P53, uncoupling protein 2, bcl-2, bax and caspase 3, etc.) as evidence of oxidative stress as a \"secondary And the relationship between the signal pathway and the decoupling protein 2 on the oxidative stress and apoptosis of the liver. To confirm the presence of ketone dairy cows with hyperoxemia and hyperviscosity free fatty acid caused by oxidative stress in the liver and the liver damage caused by it, and to further reveal the pathogenesis of dairy cow disease and to find a new drug therapy target to provide the theory in accordance with.", 
    "endDate": "2014-12-31T00:00:00Z", 
    "funder": {
      "id": "https://www.grid.ac/institutes/grid.419696.5", 
      "type": "Organization"
    }, 
    "id": "sg:grant.6997893", 
    "identifier": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "6997893"
        ]
      }, 
      {
        "name": "nsfc_id", 
        "type": "PropertyValue", 
        "value": [
          "31101868"
        ]
      }
    ], 
    "inLanguage": [
      "zh"
    ], 
    "keywords": [
      "vitro", 
      "cell biology", 
      "accordance", 
      "relationship", 
      "second strike", 
      "vivo", 
      "new drug therapy target", 
      "glutathione", 
      "METHODS", 
      "liver damage", 
      "molecular biology", 
      "effect", 
      "theoretical hypotheses", 
      "Bax", 
      "important nutritional metabolic disease", 
      "main pathologic features", 
      "oxidative stress", 
      "liver cell apoptosis", 
      "hypoglycemia", 
      "antioxidant indices", 
      "hyperviscosity", 
      "hyperglycemia", 
      "Liver Dairy Cow", 
      "liver", 
      "ability", 
      "superoxide dismutase", 
      "presence", 
      "glutathione peroxidase", 
      "pathological hyperglycemia", 
      "Dairy cow ketosis", 
      "protein 2", 
      "ketone dairy cows", 
      "theory", 
      "ketosis disease", 
      "decoupling protein 2", 
      "hyperoxemia", 
      "caspase 3", 
      "evidence", 
      "biochemical detection", 
      "Bcl-2", 
      "apoptosis", 
      "signal pathways", 
      "pathogenesis", 
      "p53", 
      "perinatal dairy cows", 
      "free fatty acids", 
      "primary hepatocytes", 
      "project", 
      "hepatic apoptosis", 
      "dairy cow diseases"
    ], 
    "name": "Effects of Oxidative Stress on Hepatic Apoptosis in Liver Dairy Cow", 
    "recipient": [
      {
        "id": "https://www.grid.ac/institutes/grid.412243.2", 
        "type": "Organization"
      }, 
      {
        "affiliation": {
          "id": "https://www.grid.ac/institutes/grid.412243.2", 
          "name": "Northeast Agricultural University", 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Zhi Gang", 
        "id": "sg:person.01243320653.09", 
        "type": "Person"
      }, 
      {
        "member": "sg:person.01243320653.09", 
        "roleName": "PI", 
        "type": "Role"
      }
    ], 
    "sameAs": [
      "https://app.dimensions.ai/details/grant/grant.6997893"
    ], 
    "sdDataset": "grants", 
    "sdDatePublished": "2019-03-07T12:41", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com.uberresearch.data.processor/core_data/20181219_192338/projects/base/nsfc_projects_2.xml.gz", 
    "startDate": "2012-01-01T00:00:00Z", 
    "type": "MonetaryGrant", 
    "url": "http://npd.nsfc.gov.cn/projectDetail.action?pid=31101868"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/grant.6997893'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/grant.6997893'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/grant.6997893'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/grant.6997893'


 

This table displays all metadata directly associated to this object as RDF triples.

94 TRIPLES      19 PREDICATES      72 URIs      64 LITERALS      5 BLANK NODES

Subject Predicate Object
1 sg:grant.6997893 schema:about anzsrc-for:2206
2 schema:amount N34eb14564a434dc8b42fcc80988998f2
3 schema:description Dairy cow ketosis is an important nutritional metabolic disease of perinatal dairy cows. The main pathologic features are hypoglycemia, hyperglycemia and hyperviscosity free fatty acid. This project to ketosis pathological hyperglycemia and hyperviscosity free fatty acid to weaken the ability of liver antioxidant and promote liver cell apoptosis, and then lead to liver "second strike" for the theoretical hypothesis. Using the methods of molecular biology, cell biology and biochemical detection, the antioxidant indexes (superoxide dismutase, glutathione, glutathione, glutathione, glutathione and glutathione peroxidase) were measured by in vivo (ketosis disease) and in vitro (primary hepatocyte) (P53, uncoupling protein 2, bcl-2, bax and caspase 3, etc.) as evidence of oxidative stress as a "secondary And the relationship between the signal pathway and the decoupling protein 2 on the oxidative stress and apoptosis of the liver. To confirm the presence of ketone dairy cows with hyperoxemia and hyperviscosity free fatty acid caused by oxidative stress in the liver and the liver damage caused by it, and to further reveal the pathogenesis of dairy cow disease and to find a new drug therapy target to provide the theory in accordance with.
4 schema:endDate 2014-12-31T00:00:00Z
5 schema:funder https://www.grid.ac/institutes/grid.419696.5
6 schema:identifier N3d15643b2c7f480d9e0a9fe52f05d9b3
7 Nd95d12380f2c4941a02aafffeb234421
8 schema:inLanguage zh
9 schema:keywords Bax
10 Bcl-2
11 Dairy cow ketosis
12 Liver Dairy Cow
13 METHODS
14 ability
15 accordance
16 antioxidant indices
17 apoptosis
18 biochemical detection
19 caspase 3
20 cell biology
21 dairy cow diseases
22 decoupling protein 2
23 effect
24 evidence
25 free fatty acids
26 glutathione
27 glutathione peroxidase
28 hepatic apoptosis
29 hyperglycemia
30 hyperoxemia
31 hyperviscosity
32 hypoglycemia
33 important nutritional metabolic disease
34 ketone dairy cows
35 ketosis disease
36 liver
37 liver cell apoptosis
38 liver damage
39 main pathologic features
40 molecular biology
41 new drug therapy target
42 oxidative stress
43 p53
44 pathogenesis
45 pathological hyperglycemia
46 perinatal dairy cows
47 presence
48 primary hepatocytes
49 project
50 protein 2
51 relationship
52 second strike
53 signal pathways
54 superoxide dismutase
55 theoretical hypotheses
56 theory
57 vitro
58 vivo
59 schema:name Effects of Oxidative Stress on Hepatic Apoptosis in Liver Dairy Cow
60 schema:recipient N0fb785af77424d65b1fbc53a644c8182
61 sg:person.01243320653.09
62 https://www.grid.ac/institutes/grid.412243.2
63 schema:sameAs https://app.dimensions.ai/details/grant/grant.6997893
64 schema:sdDatePublished 2019-03-07T12:41
65 schema:sdLicense https://scigraph.springernature.com/explorer/license/
66 schema:sdPublisher N03a27fb474ae4f34aaec37c230c43191
67 schema:startDate 2012-01-01T00:00:00Z
68 schema:url http://npd.nsfc.gov.cn/projectDetail.action?pid=31101868
69 sgo:license sg:explorer/license/
70 sgo:sdDataset grants
71 rdf:type schema:MonetaryGrant
72 N03a27fb474ae4f34aaec37c230c43191 schema:name Springer Nature - SN SciGraph project
73 rdf:type schema:Organization
74 N0fb785af77424d65b1fbc53a644c8182 schema:member sg:person.01243320653.09
75 schema:roleName PI
76 rdf:type schema:Role
77 N34eb14564a434dc8b42fcc80988998f2 schema:currency CNY
78 schema:value 230000
79 rdf:type schema:MonetaryAmount
80 N3d15643b2c7f480d9e0a9fe52f05d9b3 schema:name nsfc_id
81 schema:value 31101868
82 rdf:type schema:PropertyValue
83 Nd95d12380f2c4941a02aafffeb234421 schema:name dimensions_id
84 schema:value 6997893
85 rdf:type schema:PropertyValue
86 anzsrc-for:2206 schema:inDefinedTermSet anzsrc-for:
87 rdf:type schema:DefinedTerm
88 sg:person.01243320653.09 schema:affiliation https://www.grid.ac/institutes/grid.412243.2
89 schema:familyName Zhang
90 schema:givenName Zhi Gang
91 rdf:type schema:Person
92 https://www.grid.ac/institutes/grid.412243.2 schema:name Northeast Agricultural University
93 rdf:type schema:Organization
94 https://www.grid.ac/institutes/grid.419696.5 schema:Organization
 




Preview window. Press ESC to close (or click here)


...