Effects of Oxidative Stress on Hepatic Apoptosis in Liver Dairy Cow View Homepage


Ontology type: schema:MonetaryGrant     


Grant Info

YEARS

2012-2014

FUNDING AMOUNT

230000 CNY

ABSTRACT

Dairy cow ketosis is an important nutritional metabolic disease of perinatal dairy cows. The main pathologic features are hypoglycemia, hyperglycemia and hyperviscosity free fatty acid. This project to ketosis pathological hyperglycemia and hyperviscosity free fatty acid to weaken the ability of liver antioxidant and promote liver cell apoptosis, and then lead to liver "second strike" for the theoretical hypothesis. Using the methods of molecular biology, cell biology and biochemical detection, the antioxidant indexes (superoxide dismutase, glutathione, glutathione, glutathione, glutathione and glutathione peroxidase) were measured by in vivo (ketosis disease) and in vitro (primary hepatocyte) (P53, uncoupling protein 2, bcl-2, bax and caspase 3, etc.) as evidence of oxidative stress as a "secondary And the relationship between the signal pathway and the decoupling protein 2 on the oxidative stress and apoptosis of the liver. To confirm the presence of ketone dairy cows with hyperoxemia and hyperviscosity free fatty acid caused by oxidative stress in the liver and the liver damage caused by it, and to further reveal the pathogenesis of dairy cow disease and to find a new drug therapy target to provide the theory in accordance with. More... »

URL

http://npd.nsfc.gov.cn/projectDetail.action?pid=31101868

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