Study on Anti - tumor Activity and Mechanism of Natural Products Targeting wnt Signaling Pathway View Homepage


Ontology type: schema:MonetaryGrant     


Grant Info

YEARS

2012-2015

FUNDING AMOUNT

550000 CNY

ABSTRACT

wnt signaling pathway plays an important role in cell proliferation, differentiation and stem cell self-renewal. Pathway abnormalities are closely related to tumorigenesis and are important targets for anticancer drugs. We used the natural product research advantages of the National Key Laboratory of Phytochemistry and Western Plant Resources to screen the natural product library with the wnt signal pathway inhibitor. It was found that the new indole alkaloid compound LUO104 had obvious activity. Preliminary studies have shown that the compounds specifically regulate the activity of wnt signaling pathways and significantly induce apoptosis in vitro. We have isolated and obtained a series of natural compounds related to its structure. In this study, molecular biology and chemical biology methods were used to study the anti-tumor activity of the compounds and the mechanism of action. The molecular mechanism of the compounds to control the wnt signaling pathway , To analyze its structure-activity relationship and target, to elucidate the mechanism of anti-tumor activity of LUO104, and to lay the foundation for the development of innovative natural anti-tumor drugs targeting wnt signaling pathway. More... »

URL

http://npd.nsfc.gov.cn/projectDetail.action?pid=81173076

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