Selection signal of human genome weight-related gene locus: verification of hypothesis of "thrifty gene" View Homepage


Ontology type: schema:MonetaryGrant     


Grant Info

YEARS

2015-2015

FUNDING AMOUNT

600000 CNY

ABSTRACT

The thrifty gene hypothesis proposes that obesity is a consequence of selection in our evolutionary history which favored the spread of genes that promote fat storage. It is suggested that these thrifty genes were positively selected because people storing greater amounts of body fat were more likely to survive during periods of famine. It has been proposed that a direct test of this hypothesis would be to examine the human genome for signs of strong selection in the neighborhood of genes that have been associated with obesity. To date about 38 SNPs have been associated with body mass index (BMI) in genome wide association studies (GWAS).. Unfortunately BMI is a very imprecise measure of body fatness and SNPs leading to changes in BMI do not necessarily need to impact on stored body fat levels. For example, genes influencing lean tissue mass will also have effects on BMI. The de novo data set will include measurements of body fatness using more precise and accurate measurements than BMI (based on deuterium dilution and the bioimpedance methods) in a population of 300 urban living Han Chinese. In addition we will measure the SNP profiles of these individuals using the affymetrix axiom phase I and II arrays which contain 1.2 million SNPs covering 90% of the genome. We will use these data to confirm which SNPs link More... »

URL

http://npd.nsfc.gov.cn/projectDetail.action?pid=91431102

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