Physiological and pathological mechanisms of skeletal muscle View Homepage


Ontology type: schema:MonetaryGrant     


Grant Info

YEARS

2010-2013

FUNDING AMOUNT

838767.0 EUR

ABSTRACT

The purpose of this project is to conduct a systematic study of the structure-function relationship of the skeletal muscle from the tissue to the molecular level in physiological and pathological conditions and during remodeling. The research units involved in the project ensure a multidisciplinary approach from Cellular and Molecular Biology to Physiology and Biophysics and integrate the results of their different approaches to ensure optimal scientific synergy between those of leading national experts and their international collaborators. LOMBARDI (University of Florence) studies the molecular motor of skeletal muscle and the role of his organization in sarcomere by applying advanced biophysical techniques to integrate structural, mechanical and biochemical information from the muscle to the single molecules (mechanical and X-ray diffraction on whole muscle and single Fibers, chemomechanics on demagnetic fibers, in vitro and nanomechanical motility tests on purified proteins). The problems faced include (i) changes in actin and myosin filaments that induce the development of isometric force, (ii) the kinetic and mechanical properties of the myosinic motor underlying muscle power and efficiency during stable shortening, and (iii) The interaction between cytoskeletal proteins and myosin molecules (and their dimeric structure) during muscle brake action in response to a sudden increase in cargo. CECCHI (University of Florence) uses rapid mechanical methods in single fibers or mammalian muscle fiber bundles to define the molecular mechanism of fatigue. The ECEC unit is also expert in myofibratic mechanics, an approach that allows to study the regulation and kinetics of myosin-actin interaction under conditions where it is possible to control the concentration of Ca2 + activator and the ligand composition. Biophysical methods developed by LOMBARDI and CECCHI units are the ideal support for the growing demand for structural and mechanical information on the molecular basis of myopathy related to aging and illness and muscular remodeling, the process by which muscle responds to the changing demands of the environment . Remodeling is influenced by the turnover of contractile proteins. The balance between the production of new myofibrils and the degradation of existing proteins depends on the condition and may cause increase or decrease in muscle mass. Synthesis and protein degradation are regulated by pathways under the control of mechanical stress, physical activity, nutrient availability and growth factors. Understanding signals that control muscle mass can provide the basis for preventing and treating muscular injury in metabolic, genetic and neuromuscular diseases. The biomolecular approach to the study of disease mechanisms and skeletal muscle remodeling is conducted by BANG, DONATE, MUSAR, SANDRI, FULLE and FATH unit units using specific animal models or human biopsies. BANG (Genetic and Biomedical Research Institute-CNR Milan) studies the role of cytoskeletal proteins and associated myopathies using knockout mice for myopalladine and / or palladium. DONATO (University of Perugia) studies the activation, proliferation, survival and differentiation of satellite cells and the phenotypic M1 / ​​M2 transition of macrophages, and their modulation by S100B. MUSARÃ (University of Rome â La Sapienzaâ) studies the role of molecular modulators of muscle growth and functional interaction between muscle and nerve. SANDRI (University of Padua) studies the role of protein degradation systems in healthy and diseased muscle by generating knockout or transgenic mice for autophagy or ubiquitin / proteasome pathway. The relationship between oxidative stress and the activation of satellite cells during muscular remodeling is studied by FULLE (University of Chieti) using in vitro cultures of human skeletal muscle cells or animal models of other units. GRASSI (University of Rome, La Sapienza) studies how electrical activity and Ca2 + signals control the differentiation of satellite cells and maturation of myotubes in physiological and pathological conditions using Ca2 + electrophysiological and imaging techniques on human and murine cultures in culture or Muscle fibers from animal models of other units. The multidisciplinary approach of the eight research units involved in this project provides a suitable potential for combining biomolecular techniques for manipulating protein expression with mechanical and structural measures on the same muscle models, enabling a new large-scale research program on skeletal muscle In physiological, pathological conditions and during remodeling. More... »

URL

http://cercauniversita.cineca.it/php5/prin/cerca.php?codice=2010R8JK2X

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