The mechanism of cell death in response to cytoplasmic DNA, and its role in tumour suppression View Homepage


Ontology type: schema:MonetaryGrant     


Grant Info

YEARS

2011-2014

FUNDING AMOUNT

517897 AUD

ABSTRACT

DNA in mammalian cells is in a structure known as the nucleus. Retroviruses such as HIV generate DNA outside the nucleus in the cytoplasm, and detection of DNA in the cytoplasm can lead to cell death, as a defence. All cells carry the remnants of ancient retroviruses in their nuclear DNA. These are normally inactive but may contribute to cancer when activated. This project investigates how normal cells die with cytoplasmic DNA, and whether a defect in this process promotes development of cancer. More... »

URL

http://purl.org/au-research/grants/nhmrc/1010887

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