Rewiring the origin of life by resurrecting an ancient pathway for DNA synthesis View Homepage


Ontology type: schema:MonetaryGrant     


Grant Info

YEARS

2014-2016

FUNDING AMOUNT

3900000 JPY

ABSTRACT

To obtain new knowledge on molecular origin of DNA, mechanism of DNA biosynthesis was investigated from new aspects, and the obtained results were applied for industrial production of DNA. As an example, by artificial modification of E. coli DNA biosynthetic pathway, deoxyribonucleotide synthesis, which is believed to be synthesized from ribonucleotide, was revealed to be synthesized from simple chemicals those existed in ancient earth environment, i.e., intermediates of glycolysis, acetaldehyde, and nucleo bases. Furthermore, an enzymatic process for the production of modified nucleoside useful for DNA drug was established. More... »

URL

https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26660064

Related SciGraph Publications

  • 2014-12. The Case for an Early Biological Origin of DNA in JOURNAL OF MOLECULAR EVOLUTION
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