Polymorphisms associated with obesity/lipid metabolism/carbohydrate metabolism in Oceanic populations View Homepage


Ontology type: schema:MonetaryGrant     


Grant Info

YEARS

2013-2016

FUNDING AMOUNT

19110000 JPY

ABSTRACT

Analysis of the genome-wide SNP data suggested that the Polynesian ancestor came from Southeast Asia to Melanesia and mixed with indigenous Melanesian. The present-day Polynesian may have had obesity-risk alleles both from Southeast Asians and indigenous Melanesian.Oleoylethanolamide (OEA), an appetite-suppressing mediator, is degraded by an integral membrane enzyme encoded by the fatty acid amide hydrolase (FAAH) gene. A previous study demonstrated that the activity of FAAH enzyme was influenced by a non-synonymous SNP (rs324420; Pro129Thr) in the FAAH gene. The FAAH activity was higher in peripheral blood T-lymphocytes obtained from subjects homozygous for rs324420-C (129Pro) than in those for rs324420-A (129Thr). In the present study, the rs324420-C allele was significantly associated with increase in BMI. Our results suggest that the efficient degradation of OEA caused by FAAH rs324420-C may lead to excessive food intake and significant weight gain in Oceanic populations. More... »

URL

https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25291103

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