Enhancement of intraarticular tissue repairs by injecting a large number of synovial stem cells into the knee joint View Homepage


Ontology type: schema:MonetaryGrant     


Grant Info

YEARS

2006-2007

FUNDING AMOUNT

4010000 JPY

ABSTRACT

We investigated the role and effect of synovial stem cells in the knee joint.(1) We isolated rat mesenchymal stem cells (MSCs) from bone marrow, synovium, periosteum, adipose, muscle and compared their properties for yield, expansion, and multipotentiality. Synovial stem cells had the greatest potential for both proliferation and chondrogenesis.(2) We examined the features of adipose synovium-stem cells, fibrous synovium-stem cells, and subcutaneous fat-stem cells to determine their similarities. Adipose synovium-stem cells were more similar to fibrous synovium-derived cells than to subcutaneous fat-stem cells.(3) We transplanted undifferentiated synovial stem cells into a full-thickness articular cartilage defect of adult rabbits and defined the cellular events. Transplanted synovial stem cells were altered over a time course according to the microenvironments.(4) We examined the behavior and properties of MSCs derived from synovial fluid. Synovial fluid-MSCs were similar to synovium-MSCs, and increased in number after anterior cruciate ligament injury and surgery without marked alteration of the properties.(5) We investigated whether synovial fluid expanded synovial MSCs. Autologous synovial fluid enhanced expansion of MSCs in tissue culture of synovium from osteoarthritis patients by promoting cell migration.(6) We investigated the effect and mechanism of the implantation of the synovial MSCs on tendon-bone healing in rats. Implantation of synovial MSCs into bone tunnel accelerated early remodeling of tendon-bone healing.These results demonstrate that intraarticular injection of synovial MSCs can boost natural healing ability in the joint. Intraarticular injection of synovial stem cells is attractive because it requires no invasive procedure or artificial scaffold. More... »

URL

https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18591657

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/2211", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }
    ], 
    "amount": {
      "currency": "JPY", 
      "type": "MonetaryAmount", 
      "value": "4010000"
    }, 
    "description": "We investigated the role and effect of synovial stem cells in the knee joint.(1) We isolated rat mesenchymal stem cells (MSCs) from bone marrow, synovium, periosteum, adipose, muscle and compared their properties for yield, expansion, and multipotentiality. Synovial stem cells had the greatest potential for both proliferation and chondrogenesis.(2) We examined the features of adipose synovium-stem cells, fibrous synovium-stem cells, and subcutaneous fat-stem cells to determine their similarities. Adipose synovium-stem cells were more similar to fibrous synovium-derived cells than to subcutaneous fat-stem cells.(3) We transplanted undifferentiated synovial stem cells into a full-thickness articular cartilage defect of adult rabbits and defined the cellular events. Transplanted synovial stem cells were altered over a time course according to the microenvironments.(4) We examined the behavior and properties of MSCs derived from synovial fluid. Synovial fluid-MSCs were similar to synovium-MSCs, and increased in number after anterior cruciate ligament injury and surgery without marked alteration of the properties.(5) We investigated whether synovial fluid expanded synovial MSCs. Autologous synovial fluid enhanced expansion of MSCs in tissue culture of synovium from osteoarthritis patients by promoting cell migration.(6) We investigated the effect and mechanism of the implantation of the synovial MSCs on tendon-bone healing in rats. Implantation of synovial MSCs into bone tunnel accelerated early remodeling of tendon-bone healing.These results demonstrate that intraarticular injection of synovial MSCs can boost natural healing ability in the joint. Intraarticular injection of synovial stem cells is attractive because it requires no invasive procedure or artificial scaffold.", 
    "endDate": "2007-12-31T00:00:00Z", 
    "funder": {
      "id": "https://www.grid.ac/institutes/grid.54432.34", 
      "type": "Organization"
    }, 
    "id": "sg:grant.5966179", 
    "identifier": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "5966179"
        ]
      }, 
      {
        "name": "kaken_id", 
        "type": "PropertyValue", 
        "value": [
          "18591657"
        ]
      }
    ], 
    "inLanguage": [
      "en"
    ], 
    "keywords": [
      "synovium", 
      "features", 
      "properties.(5", 
      "role", 
      "muscle", 
      "knee joint", 
      "fibrous synovium-derived cells", 
      "tendon-bone healing", 
      "synovium-stem cells", 
      "properties", 
      "isolated rat", 
      "full-thickness articular cartilage defects", 
      "Adipose synovium-stem cells", 
      "early remodeling", 
      "subcutaneous fat-stem cells", 
      "number", 
      "periosteum", 
      "natural healing ability", 
      "anterior cruciate ligament injury", 
      "proliferation", 
      "multipotentiality", 
      "subcutaneous fat-stem cells.(3", 
      "rats", 
      "surgery", 
      "adipose", 
      "chondrogenesis.(2", 
      "yield", 
      "adult rabbits", 
      "expansion", 
      "similarity", 
      "time course", 
      "autologous synovial fluid", 
      "knee joint.(1", 
      "synovium-MSCs", 
      "results", 
      "alterations", 
      "synovial MSCs", 
      "mechanism", 
      "synovial fluid", 
      "intraarticular tissue repairs", 
      "enhancement", 
      "bone marrow", 
      "synovial stem cells", 
      "mesenchymal stem cells", 
      "osteoarthritis patients", 
      "implantation", 
      "artificial scaffolds", 
      "intraarticular injection", 
      "behavior", 
      "microenvironments.(4", 
      "great potential", 
      "cellular events", 
      "undifferentiated synovial stem cells", 
      "fibrous synovium-stem cells", 
      "bone tunnel", 
      "effect", 
      "tissue culture", 
      "invasive procedures", 
      "cell migration.(6", 
      "large number", 
      "Synovial fluid-MSCs"
    ], 
    "name": "Enhancement of intraarticular tissue repairs by injecting a large number of synovial stem cells into the knee joint", 
    "recipient": [
      {
        "id": "https://www.grid.ac/institutes/grid.265073.5", 
        "type": "Organization"
      }
    ], 
    "sameAs": [
      "https://app.dimensions.ai/details/grant/grant.5966179"
    ], 
    "sdDataset": "grants", 
    "sdDatePublished": "2019-03-07T11:43", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com.uberresearch.data.processor/core_data/20181219_192338/projects/base/kaken_projects_21.xml.gz", 
    "startDate": "2006-01-01T00:00:00Z", 
    "type": "MonetaryGrant", 
    "url": "https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18591657"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/grant.5966179'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/grant.5966179'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/grant.5966179'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/grant.5966179'


 

This table displays all metadata directly associated to this object as RDF triples.

95 TRIPLES      19 PREDICATES      81 URIs      74 LITERALS      4 BLANK NODES

Subject Predicate Object
1 sg:grant.5966179 schema:about anzsrc-for:2211
2 schema:amount N10c7d28d54c741ad8013775cb65127a4
3 schema:description We investigated the role and effect of synovial stem cells in the knee joint.(1) We isolated rat mesenchymal stem cells (MSCs) from bone marrow, synovium, periosteum, adipose, muscle and compared their properties for yield, expansion, and multipotentiality. Synovial stem cells had the greatest potential for both proliferation and chondrogenesis.(2) We examined the features of adipose synovium-stem cells, fibrous synovium-stem cells, and subcutaneous fat-stem cells to determine their similarities. Adipose synovium-stem cells were more similar to fibrous synovium-derived cells than to subcutaneous fat-stem cells.(3) We transplanted undifferentiated synovial stem cells into a full-thickness articular cartilage defect of adult rabbits and defined the cellular events. Transplanted synovial stem cells were altered over a time course according to the microenvironments.(4) We examined the behavior and properties of MSCs derived from synovial fluid. Synovial fluid-MSCs were similar to synovium-MSCs, and increased in number after anterior cruciate ligament injury and surgery without marked alteration of the properties.(5) We investigated whether synovial fluid expanded synovial MSCs. Autologous synovial fluid enhanced expansion of MSCs in tissue culture of synovium from osteoarthritis patients by promoting cell migration.(6) We investigated the effect and mechanism of the implantation of the synovial MSCs on tendon-bone healing in rats. Implantation of synovial MSCs into bone tunnel accelerated early remodeling of tendon-bone healing.These results demonstrate that intraarticular injection of synovial MSCs can boost natural healing ability in the joint. Intraarticular injection of synovial stem cells is attractive because it requires no invasive procedure or artificial scaffold.
4 schema:endDate 2007-12-31T00:00:00Z
5 schema:funder https://www.grid.ac/institutes/grid.54432.34
6 schema:identifier N0485926a941f4365887487dbd2bdc253
7 Ne1f8c3789d644d52b1a95a00e5a4b246
8 schema:inLanguage en
9 schema:keywords Adipose synovium-stem cells
10 Synovial fluid-MSCs
11 adipose
12 adult rabbits
13 alterations
14 anterior cruciate ligament injury
15 artificial scaffolds
16 autologous synovial fluid
17 behavior
18 bone marrow
19 bone tunnel
20 cell migration.(6
21 cellular events
22 chondrogenesis.(2
23 early remodeling
24 effect
25 enhancement
26 expansion
27 features
28 fibrous synovium-derived cells
29 fibrous synovium-stem cells
30 full-thickness articular cartilage defects
31 great potential
32 implantation
33 intraarticular injection
34 intraarticular tissue repairs
35 invasive procedures
36 isolated rat
37 knee joint
38 knee joint.(1
39 large number
40 mechanism
41 mesenchymal stem cells
42 microenvironments.(4
43 multipotentiality
44 muscle
45 natural healing ability
46 number
47 osteoarthritis patients
48 periosteum
49 proliferation
50 properties
51 properties.(5
52 rats
53 results
54 role
55 similarity
56 subcutaneous fat-stem cells
57 subcutaneous fat-stem cells.(3
58 surgery
59 synovial MSCs
60 synovial fluid
61 synovial stem cells
62 synovium
63 synovium-MSCs
64 synovium-stem cells
65 tendon-bone healing
66 time course
67 tissue culture
68 undifferentiated synovial stem cells
69 yield
70 schema:name Enhancement of intraarticular tissue repairs by injecting a large number of synovial stem cells into the knee joint
71 schema:recipient https://www.grid.ac/institutes/grid.265073.5
72 schema:sameAs https://app.dimensions.ai/details/grant/grant.5966179
73 schema:sdDatePublished 2019-03-07T11:43
74 schema:sdLicense https://scigraph.springernature.com/explorer/license/
75 schema:sdPublisher N835afb32119b46c0955b056586b28276
76 schema:startDate 2006-01-01T00:00:00Z
77 schema:url https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18591657
78 sgo:license sg:explorer/license/
79 sgo:sdDataset grants
80 rdf:type schema:MonetaryGrant
81 N0485926a941f4365887487dbd2bdc253 schema:name dimensions_id
82 schema:value 5966179
83 rdf:type schema:PropertyValue
84 N10c7d28d54c741ad8013775cb65127a4 schema:currency JPY
85 schema:value 4010000
86 rdf:type schema:MonetaryAmount
87 N835afb32119b46c0955b056586b28276 schema:name Springer Nature - SN SciGraph project
88 rdf:type schema:Organization
89 Ne1f8c3789d644d52b1a95a00e5a4b246 schema:name kaken_id
90 schema:value 18591657
91 rdf:type schema:PropertyValue
92 anzsrc-for:2211 schema:inDefinedTermSet anzsrc-for:
93 rdf:type schema:DefinedTerm
94 https://www.grid.ac/institutes/grid.265073.5 schema:Organization
95 https://www.grid.ac/institutes/grid.54432.34 schema:Organization
 




Preview window. Press ESC to close (or click here)


...