Development of anti-cancer agents targeting R-spondin-LGR4/5/6-ZNRF3/RNF43 axis View Homepage


Ontology type: schema:MonetaryGrant     


Grant Info

YEARS

2015-2018

FUNDING AMOUNT

17680000.0 JPY

ABSTRACT

Utilizing a novel assay system targeting R-spondin-LGR4/5/6-ZNRF3/RNF43 axis, we first screened a small-molecule compound library to elucidate the R-spondin inhibitors as the anti-cancer agents and the R-spondin substitutes as the stimulating factors of intestinal stem cells. As the results, 60 compounds for inhibitor and one compound for stimulator became the candidates.As the succeeding analysis, the stimulator was confirmed to act through R-spondin-LGR4/5/6-ZNRF3/RNF43 axis, which indicated that the compound would be a promising seed of agents in the field of gastrointestinal regenerative medicine. More... »

URL

https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H04806

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