Research on ES cells, elucidation and its clinical application of the proliferation and differentiation mechanism of tissue stem cells View Homepage


Ontology type: schema:MonetaryGrant     


Grant Info

YEARS

2001-2005

FUNDING AMOUNT

342550000 JPY

ABSTRACT

To our organs, tissue-specific stem cells that have the capacity for self-renewal differentiation potential (tissue stem cells) are present. In recent years, a variety of tissue stem cells were amplified by the ex vivo new medical care using the same, but have been actively carried out research with the aim of so-called regenerative medicine, separation method of tissue stem cells, molecules that are involved in self-renewal and proliferation and differentiation scarcely successful even be but not identified. Recently established human ES cells are social, but have had ethical issues, on the other hand, that do not can produce the cells and organs for transplantation that is a chronic shortage of using this cell expectations have also been inflated. ES cells totipotent under culture conditions, since the self-replicating while maintaining pluripotency, if it is possible to establish a culture system to differentiate a specific tissue stem cells from ES cells, infinite cells and organs of interest It is considered to be possible to produce the. However, currently, a method of inducing specific tissue stem cells from ES cells even in mice system has not been established. In this study, to clarify the cell biology properties and the type of tissue stem cells of mouse and human, self-replication of each of tissue stem cells, proliferation, differentiation, and identify molecules that are involved in transformation, hematopoietic stem cells, such as liver stem cells We have developed a platform technology to amplify tissue stem cells. Further, to clarify the molecules that act specifically on induction of differentiation from mouse ES cells into tissue stem cells of neural stem cells, etc., attempted in vitro construction of hematopoiesis using monkey ES cells were used future human ES cells with the research. In addition, by establishing the ex vivo amplification method of tissue stem cells present in human bone marrow and umbilical cord blood, hematopoietic stem cell transplantation using the amplification tissue stem cells, liver cell transplantation, cardiac muscle cell transplantation, a new regenerative medicine, such as a nerve cell transplantation the development of, playback using tissue stem cells that were specifically produced from ES cells medicine, was carried out fundamental technology development of regenerative medicine. More... »

URL

https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13GS0009

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