In vivo tracing and safety of novel nanomaterials graphene View Homepage


Ontology type: schema:MonetaryGrant     


Grant Info

YEARS

2010-2013

FUNDING AMOUNT

420000 CNY

ABSTRACT

Graphene is the second member of the new carbon nanotube carbon nanomaterials family, has excellent physical and chemical properties, in various fields of electronic devices, materials, energy, biotechnology and others have potentially widespread applications, is currently the most talked about international a new kinds of materials. The current study focused on the chemical and physical properties and applications of graphene biological effects and safety of the lack of knowledge. Nanomaterials biological safety of nanotechnology research is the basis for sustained and healthy development, the current study shows that nano-biological effects and safety needs for each material individually (case by case) study, there is no universal conclusions. Therefore, biodistribution and biological effects of graphene research is imperative. On the basis of the applicant's previous studies on this topic and the proposed use of radioactive stable isotope labeling, graphene and their biodistribution and in vivo fate of the important derivatives of graphene oxide, graphene and conduct biological effects at the cellular level and animals study (ie, toxicity and mechanism of cell research, respiratory, oral and intravenous exposure mode toxicity in animal models), the goal is to establish graphene tracer technique in vivo, initially revealed graphene distribution in vivo biological effects and mechanism of action provide important data to support graphene and safety assessment. More... »

URL

http://npd.nsfc.gov.cn/projectDetail.action?pid=21071094

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