Effect and mechanism 14-3-3β in glioma stem cells View Homepage


Ontology type: schema:MonetaryGrant     


Grant Info

YEARS

2010-2013

FUNDING AMOUNT

350000 CNY

ABSTRACT

Found in a variety of tumors with stem cell properties of cancer stem cells, because of its strong ability to regenerate the tumor and radiotherapy, chemotherapy resistance, the root causes of cancer and is considered a potential therapeutic target. However glioma stem cells which molecules regulated by? How its regulatory mechanism? It reported less widely known 14-3-3β involved in a variety of tumor proliferation and apoptosis regulation. Our previous studies also found 14-3-3β highly specific expression in gliomas, inhibiting its expression induces apoptosis in glioma cells. 14-3-3β molecular identification of glioma stem cells in gliomas CD133 co-localized phenomenon and is highly expressed in glioma stem cells. This study was based on previous work in glioma stem cells as an object, analysis 14-3-3β in glioma stem cells in the expression system to produce explore 14-3-3β glioma stem cells to maintain , proliferation and differentiation behavior of the cells, and then in-depth study 14-3-3β may affect the molecular mechanism of glioma stem cells. These studies further understand the molecular mechanism of glioma stem cells, as well as the establishment of 14-3-3β targeting interventions glioma stem cells, has important theoretical significance and social value. More... »

URL

http://npd.nsfc.gov.cn/projectDetail.action?pid=81072083

Related SciGraph Publications

  • 2012-03. Targeting 14-3-3zeta in cancer therapy in CANCER GENE THERAPY
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