Buyanghuanwu soup promote migration and survival effects and mechanism after cerebral ischemia and angiogenesis on the area next room neuroblasts ... View Homepage


Ontology type: schema:MonetaryGrant     


Grant Info

YEARS

2010-2013

FUNDING AMOUNT

330000 CNY

ABSTRACT

Cerebral ischemia adults leading causes of disability. Although cerebral ischemia-induced neurogenesis in the brain can promote tissue repair, but not enough to improve the neurological deficit. The study found brain ischemia-induced angiogenesis can promote lower chamber zone neuroblasts migration and survival to the ischemic peripheral zone, thus speeding up the recovery of neurological function. Our previous study showed that Buyanghuanwu soup can promote cerebral ischemia in rats long-term neurological function. Recent preliminary studies show, Buyanghuanwu soup can promote angiogenesis in ischemic peripheral zone. The project intends to further clarify the first five Tang Yang also affect angiogenesis after cerebral ischemia and functional recovery, and in vivo and in vitro from VEGF / Flk1 and Ang1 / Tie2 signaling pathway Mechanism; then endostatin (endostatin) inhibit angiogenesis after cerebral ischemia, clarify Buyanghuanwu soup promote neuroblastoma cell migration under room area of ​​angiogenesis, survival and functional recovery, and in vivo and in vitro to explore the molecular mechanism from SDF1 / CXCR4 axis angle and BDNF . The results of this project will not only help reveal Buyanghuanwu soup brain mechanisms promoting tissue repair and functional recovery, but also for the treatment of cerebral ischemia provides a new idea. More... »

URL

http://npd.nsfc.gov.cn/projectDetail.action?pid=81073075

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