The microRNA regulation of DNA damage checkpoint treatment of chemotherapy-resistant breast cancer stem cells View Homepage


Ontology type: schema:MonetaryGrant     


Grant Info

YEARS

2009-2011

FUNDING AMOUNT

200000 CNY

ABSTRACT

Cancer stem cells are an important mechanism for cancer chemotherapy resistance. Our previous studies have found that chemotherapy can enrich breast cancer stem cells, suggesting that tolerance to chemotherapy in breast cancer stem cells, the mechanism associated with abnormal activation of DNA damage checkpoint, since breast cancer stem cells and non-stem cell microRNA expression profiles of stem cells characteristics play an important regulatory role, we assume that by targeting a microRNA regulation of DNA damage checkpoint breast cancer stem cells resistant to chemotherapy. This topic plans on the basis of preliminary studies on the use of lentiviral vectors will be significantly down-regulated in breast cancer stem cells with DNA damage checkpoint-related microRNAs introducing breast cancer stem cells, in vitro cell culture and in vivo animal model of microRNAs in breast cancer stem cells to DNA damage response, apoptosis, and microRNAs in breast cancer stem cells to chemotherapy tolerance in vivo regulation, and to further explore the role of microRNAs in the regulation of target gene expression in breast cancer stem cells DNA damage checkpoint signaling pathways, specifically microRNAs in breast cancer Stem cells in drug regulatory mechanism for the development of tolerance to reverse chemotherapy metastatic breast new drug targets to provide new ideas. More... »

URL

http://npd.nsfc.gov.cn/projectDetail.action?pid=30801376

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