Wnt / β-catenin signaling pathway mediated by microRNAs regulating stem cell radiosensitivity of esophageal cancer research View Homepage


Ontology type: schema:MonetaryGrant     


Grant Info

YEARS

2009-2012

FUNDING AMOUNT

280000 CNY

ABSTRACT

Our previous experiments found that esophageal cancer cell lines after repeated X-ray irradiation, cells with stem cell properties gradually enriched cancer stem cells combined with the theory that cancer stem cells to radiation resistance is the root cause of the failure of radiotherapy; by high-throughput microRNA microarray screening of esophageal cancer stem cells and non-stem cells differentially expressed microRNA speculated that biological characteristics of stem cells and esophageal cancer related, can regulate its radiosensitivity, this effect may be through the Wnt / β-catenin signaling pathway mediated achieve. The project is planned on the basis of preliminary studies on the use of molecular biology techniques related to the regulation of microRNA expression in esophageal cancer stem cells, and in vivo experimental observation by outside radiosensitivity of tumor stem cells, the simultaneous detection of Wnt / β-catenin signaling pathway important proteins and signaling molecules, specifically its activation, ultimately proves relevant microRNA can regulate stem cell radiosensitivity of esophageal cancer, and this effect is through the Wnt / β-catenin signaling pathway mediated. The study will target cancer stem cells radiosensitization effect provide a theoretical basis for the reversal of esophageal carcinoma resist new ideas. More... »

URL

http://npd.nsfc.gov.cn/projectDetail.action?pid=30972962

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/2206", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/2211", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }
    ], 
    "amount": {
      "currency": "CNY", 
      "type": "MonetaryAmount", 
      "value": "280000"
    }, 
    "description": "Our previous experiments found that esophageal cancer cell lines after repeated X-ray irradiation, cells with stem cell properties gradually enriched cancer stem cells combined with the theory that cancer stem cells to radiation resistance is the root cause of the failure of radiotherapy; by high-throughput microRNA microarray screening of esophageal cancer stem cells and non-stem cells differentially expressed microRNA speculated that biological characteristics of stem cells and esophageal cancer related, can regulate its radiosensitivity, this effect may be through the Wnt / \u03b2-catenin signaling pathway mediated achieve. The project is planned on the basis of preliminary studies on the use of molecular biology techniques related to the regulation of microRNA expression in esophageal cancer stem cells, and in vivo experimental observation by outside radiosensitivity of tumor stem cells, the simultaneous detection of Wnt / \u03b2-catenin signaling pathway important proteins and signaling molecules, specifically its activation, ultimately proves relevant microRNA can regulate stem cell radiosensitivity of esophageal cancer, and this effect is through the Wnt / \u03b2-catenin signaling pathway mediated. The study will target cancer stem cells radiosensitization effect provide a theoretical basis for the reversal of esophageal carcinoma resist new ideas.", 
    "endDate": "2012-12-30T00:00:00Z", 
    "funder": {
      "id": "https://www.grid.ac/institutes/grid.419696.5", 
      "type": "Organization"
    }, 
    "id": "sg:grant.4973618", 
    "identifier": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "4973618"
        ]
      }, 
      {
        "name": "nsfc_id", 
        "type": "PropertyValue", 
        "value": [
          "30972962"
        ]
      }
    ], 
    "inLanguage": [
      "zh"
    ], 
    "keywords": [
      "Achieve", 
      "Wnt / \u03b2-catenin", 
      "relevant microRNA", 
      "stem cells", 
      "tumor stem cells", 
      "outside radiosensitivity", 
      "microRNA", 
      "pathway", 
      "previous experiments", 
      "esophageal cancer research", 
      "esophageal carcinoma", 
      "failure", 
      "ray irradiation", 
      "cells", 
      "preliminary study", 
      "root cause", 
      "molecular biology techniques", 
      "microRNA expression", 
      "vivo", 
      "radiotherapy", 
      "use", 
      "biological characteristics", 
      "high-throughput microRNA microarray screening", 
      "non-stem cells", 
      "effect", 
      "cancer stem cells radiosensitization effect", 
      "regulation", 
      "radiation resistance", 
      "stem cell radiosensitivity", 
      "theory", 
      "important proteins", 
      "new ideas", 
      "study", 
      "experimental observations", 
      "esophageal cancer stem cells", 
      "stem cell properties", 
      "esophageal cancer", 
      "esophageal cancer cell lines", 
      "radiosensitivity", 
      "cancer stem cells", 
      "basis", 
      "reversal", 
      "activation", 
      "simultaneous detection", 
      "project", 
      "microRNAs", 
      "molecules", 
      "theoretical basis"
    ], 
    "name": "Wnt / \u03b2-catenin signaling pathway mediated by microRNAs regulating stem cell radiosensitivity of esophageal cancer research", 
    "recipient": [
      {
        "id": "https://www.grid.ac/institutes/grid.43169.39", 
        "type": "Organization"
      }, 
      {
        "affiliation": {
          "id": "https://www.grid.ac/institutes/grid.43169.39", 
          "name": "Xi'an Jiaotong University", 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Xiao Zhi", 
        "id": "sg:person.01313015565.27", 
        "type": "Person"
      }, 
      {
        "member": "sg:person.01313015565.27", 
        "roleName": "PI", 
        "type": "Role"
      }
    ], 
    "sameAs": [
      "https://app.dimensions.ai/details/grant/grant.4973618"
    ], 
    "sdDataset": "grants", 
    "sdDatePublished": "2019-03-07T12:40", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com.uberresearch.data.processor/core_data/20181219_192338/projects/base/nsfc_projects_1.xml.gz", 
    "startDate": "2009-12-31T00:00:00Z", 
    "type": "MonetaryGrant", 
    "url": "http://npd.nsfc.gov.cn/projectDetail.action?pid=30972962"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/grant.4973618'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/grant.4973618'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/grant.4973618'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/grant.4973618'


 

This table displays all metadata directly associated to this object as RDF triples.

95 TRIPLES      19 PREDICATES      71 URIs      62 LITERALS      5 BLANK NODES

Subject Predicate Object
1 sg:grant.4973618 schema:about anzsrc-for:2206
2 anzsrc-for:2211
3 schema:amount Ne9d9afb426184ed596594af43b9bd9d3
4 schema:description Our previous experiments found that esophageal cancer cell lines after repeated X-ray irradiation, cells with stem cell properties gradually enriched cancer stem cells combined with the theory that cancer stem cells to radiation resistance is the root cause of the failure of radiotherapy; by high-throughput microRNA microarray screening of esophageal cancer stem cells and non-stem cells differentially expressed microRNA speculated that biological characteristics of stem cells and esophageal cancer related, can regulate its radiosensitivity, this effect may be through the Wnt / β-catenin signaling pathway mediated achieve. The project is planned on the basis of preliminary studies on the use of molecular biology techniques related to the regulation of microRNA expression in esophageal cancer stem cells, and in vivo experimental observation by outside radiosensitivity of tumor stem cells, the simultaneous detection of Wnt / β-catenin signaling pathway important proteins and signaling molecules, specifically its activation, ultimately proves relevant microRNA can regulate stem cell radiosensitivity of esophageal cancer, and this effect is through the Wnt / β-catenin signaling pathway mediated. The study will target cancer stem cells radiosensitization effect provide a theoretical basis for the reversal of esophageal carcinoma resist new ideas.
5 schema:endDate 2012-12-30T00:00:00Z
6 schema:funder https://www.grid.ac/institutes/grid.419696.5
7 schema:identifier N135afe388e244437932e10ffa788f520
8 N39ed2299d05449a2ac34dbb87a050aa2
9 schema:inLanguage zh
10 schema:keywords Achieve
11 Wnt / β-catenin
12 activation
13 basis
14 biological characteristics
15 cancer stem cells
16 cancer stem cells radiosensitization effect
17 cells
18 effect
19 esophageal cancer
20 esophageal cancer cell lines
21 esophageal cancer research
22 esophageal cancer stem cells
23 esophageal carcinoma
24 experimental observations
25 failure
26 high-throughput microRNA microarray screening
27 important proteins
28 microRNA
29 microRNA expression
30 microRNAs
31 molecular biology techniques
32 molecules
33 new ideas
34 non-stem cells
35 outside radiosensitivity
36 pathway
37 preliminary study
38 previous experiments
39 project
40 radiation resistance
41 radiosensitivity
42 radiotherapy
43 ray irradiation
44 regulation
45 relevant microRNA
46 reversal
47 root cause
48 simultaneous detection
49 stem cell properties
50 stem cell radiosensitivity
51 stem cells
52 study
53 theoretical basis
54 theory
55 tumor stem cells
56 use
57 vivo
58 schema:name Wnt / β-catenin signaling pathway mediated by microRNAs regulating stem cell radiosensitivity of esophageal cancer research
59 schema:recipient N1282c11a21384c8f82aedf119d38fe34
60 sg:person.01313015565.27
61 https://www.grid.ac/institutes/grid.43169.39
62 schema:sameAs https://app.dimensions.ai/details/grant/grant.4973618
63 schema:sdDatePublished 2019-03-07T12:40
64 schema:sdLicense https://scigraph.springernature.com/explorer/license/
65 schema:sdPublisher N393e29542951474e8fe815149a63182c
66 schema:startDate 2009-12-31T00:00:00Z
67 schema:url http://npd.nsfc.gov.cn/projectDetail.action?pid=30972962
68 sgo:license sg:explorer/license/
69 sgo:sdDataset grants
70 rdf:type schema:MonetaryGrant
71 N1282c11a21384c8f82aedf119d38fe34 schema:member sg:person.01313015565.27
72 schema:roleName PI
73 rdf:type schema:Role
74 N135afe388e244437932e10ffa788f520 schema:name dimensions_id
75 schema:value 4973618
76 rdf:type schema:PropertyValue
77 N393e29542951474e8fe815149a63182c schema:name Springer Nature - SN SciGraph project
78 rdf:type schema:Organization
79 N39ed2299d05449a2ac34dbb87a050aa2 schema:name nsfc_id
80 schema:value 30972962
81 rdf:type schema:PropertyValue
82 Ne9d9afb426184ed596594af43b9bd9d3 schema:currency CNY
83 schema:value 280000
84 rdf:type schema:MonetaryAmount
85 anzsrc-for:2206 schema:inDefinedTermSet anzsrc-for:
86 rdf:type schema:DefinedTerm
87 anzsrc-for:2211 schema:inDefinedTermSet anzsrc-for:
88 rdf:type schema:DefinedTerm
89 sg:person.01313015565.27 schema:affiliation https://www.grid.ac/institutes/grid.43169.39
90 schema:familyName Zhang
91 schema:givenName Xiao Zhi
92 rdf:type schema:Person
93 https://www.grid.ac/institutes/grid.419696.5 schema:Organization
94 https://www.grid.ac/institutes/grid.43169.39 schema:name Xi'an Jiaotong University
95 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...