Acetylcholine-induced c-Kit + stem cells migrate to the site of myocardial infarction View Homepage


Ontology type: schema:MonetaryGrant     


Grant Info

YEARS

2008-2010

FUNDING AMOUNT

190000 CNY

ABSTRACT

Stem cells play an important role in repair the injured heart, which is related with migration, proliferation and differentiation of stem cells in the damaged heart. During stem cell repair the injured heart, the first step is that stem cell should migrate into the injured heart. In the study, cardiac stem cell show the characteristic of AChM1-R、AChM2-R、CXCR4、Flk1 and Flt1 expression. ACh induce the expression of SDF-1 and VEGF in the myocardium. The increased expression of SDF-1 and VEGF in the myocardium can induce not only the bone marrow stem cell but also cardiac stem cell to migrate into the infracted and peri-infarcted area of myocardium. These stem cells migrated into the myocardium can proliferate and differentiate into vascular cells and cardiocytes to repair the damaged myocardium, and secretory factor from these stem cells can also further the effect of its repair the injured heart. During aboved stem cells migration, on the one hand, ACh itself can promote the migration of stem cells, which is associated with Ca2+/PKC/ERK1/2 pathway; on the other hand, the increased expression of SDF-1 and VEGF in the myocardium induced by ACh can also promote the migration of stem cells, which is associated with Ca2+/PKC pathway. In a word, besides anti-inflammatory and cell protection effects of ACh in the infract More... »

URL

http://npd.nsfc.gov.cn/projectDetail.action?pid=30700306

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/2210", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/2211", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }
    ], 
    "amount": {
      "currency": "CNY", 
      "type": "MonetaryAmount", 
      "value": "190000"
    }, 
    "description": "Stem cells play an important role in repair the injured heart, which is related with migration, proliferation and differentiation of stem cells in the damaged heart. During stem cell repair the injured heart, the first step is that stem cell should migrate into the injured heart. In the study, cardiac stem cell show the characteristic of AChM1-R\u3001AChM2-R\u3001CXCR4\u3001Flk1 and Flt1 expression. ACh induce the expression of SDF-1 and VEGF in the myocardium. The increased expression of SDF-1 and VEGF in the myocardium can induce not only the bone marrow stem cell but also cardiac stem cell to migrate into the infracted and peri-infarcted area of myocardium. These stem cells migrated into the myocardium can proliferate and differentiate into vascular cells and cardiocytes to repair the damaged myocardium, and secretory factor from these stem cells can also further the effect of its repair the injured heart. During aboved stem cells migration, on the one hand, ACh itself can promote the migration of stem cells, which is associated with Ca2+/PKC/ERK1/2 pathway; on the other hand, the increased expression of SDF-1 and VEGF in the myocardium induced by ACh can also promote the migration of stem cells, which is associated with Ca2+/PKC pathway. In a word, besides anti-inflammatory and cell protection effects of ACh in the infract", 
    "endDate": "2010-12-31T00:00:00Z", 
    "funder": {
      "id": "https://www.grid.ac/institutes/grid.419696.5", 
      "type": "Organization"
    }, 
    "id": "sg:grant.4927555", 
    "identifier": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "4927555"
        ]
      }, 
      {
        "name": "nsfc_id", 
        "type": "PropertyValue", 
        "value": [
          "30700306"
        ]
      }
    ], 
    "inLanguage": [
      "zh"
    ], 
    "keywords": [
      "important role", 
      "Kit + stem cells", 
      "effect", 
      "VEGF", 
      "ACh", 
      "stem cells", 
      "FLT1 expression", 
      "increased expression", 
      "Ca2+/PKC/ERK1/2 pathway", 
      "cell protection effects", 
      "Ca2+/PKC pathway", 
      "aboved stem cells migration", 
      "proliferation", 
      "peri", 
      "heart", 
      "repair", 
      "sites", 
      "expression", 
      "injured heart", 
      "cardiac stem cell show", 
      "cardiac stem cells", 
      "infract", 
      "study", 
      "cells", 
      "first step", 
      "differentiation", 
      "AChM1-R\u3001AChM2-R\u3001CXCR4\u3001Flk1", 
      "bone marrow stem cells", 
      "SDF-1", 
      "hand", 
      "vascular cells", 
      "words", 
      "characteristics", 
      "myocardial infarction", 
      "stem cell repair", 
      "myocardium", 
      "acetylcholine", 
      "migration", 
      "other hand", 
      "area", 
      "cardiocytes", 
      "secretory factors"
    ], 
    "name": "Acetylcholine-induced c-Kit + stem cells migrate to the site of myocardial infarction", 
    "recipient": [
      {
        "id": "https://www.grid.ac/institutes/grid.256883.2", 
        "type": "Organization"
      }, 
      {
        "affiliation": {
          "id": "https://www.grid.ac/institutes/grid.256883.2", 
          "name": "Hubei Medical University", 
          "type": "Organization"
        }, 
        "familyName": "Tang", 
        "givenName": "Jun Ming", 
        "id": "sg:person.011215312657.95", 
        "type": "Person"
      }, 
      {
        "member": "sg:person.011215312657.95", 
        "roleName": "PI", 
        "type": "Role"
      }
    ], 
    "sameAs": [
      "https://app.dimensions.ai/details/grant/grant.4927555"
    ], 
    "sdDataset": "grants", 
    "sdDatePublished": "2019-03-07T12:44", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com.uberresearch.data.processor/core_data/20181219_192338/projects/base/nsfc_projects_6.xml.gz", 
    "startDate": "2008-01-01T00:00:00Z", 
    "type": "MonetaryGrant", 
    "url": "http://npd.nsfc.gov.cn/projectDetail.action?pid=30700306"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/grant.4927555'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/grant.4927555'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/grant.4927555'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/grant.4927555'


 

This table displays all metadata directly associated to this object as RDF triples.

89 TRIPLES      19 PREDICATES      65 URIs      56 LITERALS      5 BLANK NODES

Subject Predicate Object
1 sg:grant.4927555 schema:about anzsrc-for:2210
2 anzsrc-for:2211
3 schema:amount Nd76cdd62734e4f2f8fa188828d3ae079
4 schema:description Stem cells play an important role in repair the injured heart, which is related with migration, proliferation and differentiation of stem cells in the damaged heart. During stem cell repair the injured heart, the first step is that stem cell should migrate into the injured heart. In the study, cardiac stem cell show the characteristic of AChM1-R、AChM2-R、CXCR4、Flk1 and Flt1 expression. ACh induce the expression of SDF-1 and VEGF in the myocardium. The increased expression of SDF-1 and VEGF in the myocardium can induce not only the bone marrow stem cell but also cardiac stem cell to migrate into the infracted and peri-infarcted area of myocardium. These stem cells migrated into the myocardium can proliferate and differentiate into vascular cells and cardiocytes to repair the damaged myocardium, and secretory factor from these stem cells can also further the effect of its repair the injured heart. During aboved stem cells migration, on the one hand, ACh itself can promote the migration of stem cells, which is associated with Ca2+/PKC/ERK1/2 pathway; on the other hand, the increased expression of SDF-1 and VEGF in the myocardium induced by ACh can also promote the migration of stem cells, which is associated with Ca2+/PKC pathway. In a word, besides anti-inflammatory and cell protection effects of ACh in the infract
5 schema:endDate 2010-12-31T00:00:00Z
6 schema:funder https://www.grid.ac/institutes/grid.419696.5
7 schema:identifier N6df7944683a847a598a72494d85b91c4
8 Nb986be01d2cd4a7cb32a8ebd43eb1311
9 schema:inLanguage zh
10 schema:keywords ACh
11 AChM1-R、AChM2-R、CXCR4、Flk1
12 Ca2+/PKC pathway
13 Ca2+/PKC/ERK1/2 pathway
14 FLT1 expression
15 Kit + stem cells
16 SDF-1
17 VEGF
18 aboved stem cells migration
19 acetylcholine
20 area
21 bone marrow stem cells
22 cardiac stem cell show
23 cardiac stem cells
24 cardiocytes
25 cell protection effects
26 cells
27 characteristics
28 differentiation
29 effect
30 expression
31 first step
32 hand
33 heart
34 important role
35 increased expression
36 infract
37 injured heart
38 migration
39 myocardial infarction
40 myocardium
41 other hand
42 peri
43 proliferation
44 repair
45 secretory factors
46 sites
47 stem cell repair
48 stem cells
49 study
50 vascular cells
51 words
52 schema:name Acetylcholine-induced c-Kit + stem cells migrate to the site of myocardial infarction
53 schema:recipient N6c25fd84a53a4b708bc6489f732810e0
54 sg:person.011215312657.95
55 https://www.grid.ac/institutes/grid.256883.2
56 schema:sameAs https://app.dimensions.ai/details/grant/grant.4927555
57 schema:sdDatePublished 2019-03-07T12:44
58 schema:sdLicense https://scigraph.springernature.com/explorer/license/
59 schema:sdPublisher N1efee449985f4e1199617fb1331ec6a0
60 schema:startDate 2008-01-01T00:00:00Z
61 schema:url http://npd.nsfc.gov.cn/projectDetail.action?pid=30700306
62 sgo:license sg:explorer/license/
63 sgo:sdDataset grants
64 rdf:type schema:MonetaryGrant
65 N1efee449985f4e1199617fb1331ec6a0 schema:name Springer Nature - SN SciGraph project
66 rdf:type schema:Organization
67 N6c25fd84a53a4b708bc6489f732810e0 schema:member sg:person.011215312657.95
68 schema:roleName PI
69 rdf:type schema:Role
70 N6df7944683a847a598a72494d85b91c4 schema:name nsfc_id
71 schema:value 30700306
72 rdf:type schema:PropertyValue
73 Nb986be01d2cd4a7cb32a8ebd43eb1311 schema:name dimensions_id
74 schema:value 4927555
75 rdf:type schema:PropertyValue
76 Nd76cdd62734e4f2f8fa188828d3ae079 schema:currency CNY
77 schema:value 190000
78 rdf:type schema:MonetaryAmount
79 anzsrc-for:2210 schema:inDefinedTermSet anzsrc-for:
80 rdf:type schema:DefinedTerm
81 anzsrc-for:2211 schema:inDefinedTermSet anzsrc-for:
82 rdf:type schema:DefinedTerm
83 sg:person.011215312657.95 schema:affiliation https://www.grid.ac/institutes/grid.256883.2
84 schema:familyName Tang
85 schema:givenName Jun Ming
86 rdf:type schema:Person
87 https://www.grid.ac/institutes/grid.256883.2 schema:name Hubei Medical University
88 rdf:type schema:Organization
89 https://www.grid.ac/institutes/grid.419696.5 schema:Organization
 




Preview window. Press ESC to close (or click here)


...