Positive effect of methoxyflavones on pig intestinal inflammation diseases caused by bacteria and oxidative stress. An in vitro study. View Homepage


Ontology type: schema:MonetaryGrant     


Grant Info

YEARS

2012-2016

FUNDING AMOUNT

9492000 HUF

ABSTRACT

Complex in vitro model system has been developed in order to study the effect of different polyphenols on the gastrointestinal tract. The model is suitable to mimic bacterial inflammation, oxidative stress and impairment of intestinal barrier as well. Role of methylated- and hydroxylated flavones (apigenin, quercetin and their derivatives) and other polyphenols such as chlorogenic acid in protection of gastrointestinal health have been tested. Effect of polyphenols has been also studied in the presence of components such as probiotic bacteria and sodium-butyrate representing the in vivo conditions in the small intestine. It could be concluded, that not only hydroxy- but methoxyflavones with lower antioxidant capacity are able to reduce bacterial-induced oxidative stress. Both hydroxy- and methoxy derivatives could decrease intestinal inflammation, but their effect on inflammatory markers is different. For example, methylated apigenin decreased COX-2 mRNA significantly than apigenin, while it could not reduce the IL-6 level. The results also show that polyphenols could influence the activity of metabolizing enzymes, which could lead to food-drug interactions. The results show, that both hydroxy- and methoxyflavones could be used in prevention as well as for therapeutic purposes in animal breeding. More... »

URL

http://nyilvanos.otka-palyazat.hu/index.php?menuid=930&num=105718&lang=EN

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