Study of Undiagnosed Diseases Genes in Zebrafish View Homepage


Ontology type: schema:MonetaryGrant     


Grant Info

YEARS

2014-2017

FUNDING AMOUNT

462000 USD

ABSTRACT

DESCRIPTION (provided by applicant): We have recently demonstrated that gene targeting via homologous recombination in zebrafish is feasible (Zuatal, Nature Methods, 2013). Homologous recombination in zebrafish with a dsDNA donor makes it possible to knock-in variants of human genes of rare and undiagnosed diseases into zebrafish genome. We have selected four such genes that are conserved between zebrafish and human for genomic knock-in studies. These zebrafish models should facilitate the understanding of genetics, biochemistry and pathophysiology of these newly diagnosed disease genes. More... »

URL

http://projectreporter.nih.gov/project_info_description.cfm?aid=8927031

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