Translation of the immunological synapse.


Ontology type: schema:MonetaryGrant     


Grant Info

YEARS

2013-2020

FUNDING AMOUNT

4871200 GBP

ABSTRACT

My goal is to further develop the quantitative analysis of the immunological synapse as a diagnostic tool for human translational research and a platform for evaluation of future therapeutics. In order to achieve these goals as soon as possible, we need to scale up and integrate the platform we have developed into the kind of framework that the Structural Genomics Consortium (SGC) has applied to crystallography. In order to achieve this I will use the move to dramatically change the compositio n of my lab from primarily biologists to a mixture of biologists, engineers, mathematicians and medical scientists. Most of the effort will go into developing high throughput immunological synapse analysis and integration of this analysis with study of disease mechanisms and interventions. Like many systems biology efforts we will deliver a large amount of data that will be made publically available through databases and the institute web site. We will develop the standards for sharing image d ata with other labs performing such screens internationally to achieve maximal compatibility. I will link our immunological synapse analysis to genomic and proteomic projects underway at the Oxford Campus to maximize synergy. I will recruit strong interdisciplinary staff and trainees to work at the interface between immunology, structural biology, computer science and engineering. The lab will continue to operate as a training center and will develop new technologies that will complement othe r modes of analysis. The platform will be applicable to reconstitution of other types of cell-cell communication leading to other collaborations. More... »

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