one year extension - Cambridge Institute for Medical Research (CIMR)


Ontology type: schema:MonetaryGrant     


Grant Info

YEARS

2011-2012

FUNDING AMOUNT

693239 GBP

ABSTRACT

A major objective for CIMR over the next 5 years is to better understand protein localisation, function and metabolism in a range of diseases in which genetic studies have identified the causative genes. Underpinning our core facilities is essential to achieve this objective and will provide added value to the considerable investment that the Wellcome Trust is already making to our scientific activities. Our present scientific goals are: (i) determination of the molecular mechanisms of intracellular protein aggregate formation and breakdown in health and disease, including the identification of novel therapeutic targets for protein conformational diseases; (ii) identifying and characterising the molecular machinery of intracellular membrane traffic and determining how traffic pathways are coordinated, regulated and modified in health and disease; (iii) the identification of genes, proteins and pathways increasing susceptibility to, or protection from, autoimmune diseases; (iv) determining the transcriptional regulation of haematopoietic stem cells. Our proposal includes funding of core specialist scientific staff, annual research retreats, funds to encourage young clinicians back into research and a case for 2 PhD students per annum. We aim to make CIMR a flagship in the UK for interdisciplinary research at the interface between clinical and basic research. More... »

Related SciGraph Publications

  • 2017-07. Type I interferon as a biomarker in autoimmunity and viral infection: a leukocyte subset-specific analysis unveils hidden diagnostic options in JOURNAL OF MOLECULAR MEDICINE
  • 2016-12. Targeted genomic analysis reveals widespread autoimmune disease association with regulatory variants in the TNF superfamily cytokine signalling network in GENOME MEDICINE
  • 2016-09. S1PR2 variants associated with auditory function in humans and endocochlear potential decline in mouse in SCIENTIFIC REPORTS
  • 2016-08. Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine in NATURE GENETICS
  • 2016-01. Renal peroxiredoxin 6 interacts with anion exchanger 1 and plays a novel role in pH homeostasis in KIDNEY INTERNATIONAL
  • 2015-12. A role for VAX2 in correct retinal function revealed by a novel genomic deletion at 2p13.3 causing distal Renal Tubular Acidosis: case report in BMC MEDICAL GENETICS
  • 2015-12. Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation in NATURE COMMUNICATIONS
  • 2015-07. T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection in NATURE
  • 2014-12. Comparison of gene expression microarray data with count-based RNA measurements informs microarray interpretation in BMC GENOMICS
  • 2013-06. Leukocyte and serum S100A8/S100A9 expression reflects disease activity in ANCA-associated vasculitis and glomerulonephritis in KIDNEY INTERNATIONAL
  • 2012-12. The binding of Varp to VAMP7 traps VAMP7 in a closed, fusogenically inactive conformation in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2012-10. Autophagy receptors link myosin VI to autophagosomes to mediate Tom1-dependent autophagosome maturation and fusion with the lysosome in NATURE CELL BIOLOGY
  • 2012-07. Genetic association of zinc transporter 8 (ZnT8) autoantibodies in type 1 diabetes cases in DIABETOLOGIA
  • 2012-04. Confirmation of novel type 1 diabetes risk loci in families in DIABETOLOGIA
  • 2011-12. Evidence of association with type 1 diabetes in the SLC11A1 gene region in BMC MEDICAL GENETICS
  • 2011-12. Antibodies against insulin measured by electrochemiluminescence predicts insulitis severity and disease onset in non-obese diabetic mice and can distinguish human type 1 diabetes status in JOURNAL OF TRANSLATIONAL MEDICINE
  • 2011-11. Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function in NATURE GENETICS
  • 2011-10. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk in NATURE
  • 2011-08. The Parkinson's disease protein LRRK2 impairs proteasome substrate clearance without affecting proteasome catalytic activity in CELL DEATH & DISEASE
  • 2010-12. Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies in NATURE GENETICS
  • 2010-11. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index in NATURE GENETICS
  • 2010-11. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution in NATURE GENETICS
  • 2010-10. Hundreds of variants clustered in genomic loci and biological pathways affect human height in NATURE
  • 2010-10. Ten years of genetics and genomics: what have we achieved and where are we heading? in NATURE REVIEWS GENETICS
  • 2010-08. Biological, clinical and population relevance of 95 loci for blood lipids in NATURE
  • 2010-05. A CD8+ T cell transcription signature predicts prognosis in autoimmune disease in NATURE MEDICINE
  • 2010-02. Multiplexed immunophenotyping of human antigen-presenting cells in whole blood by polychromatic flow cytometry in NATURE PROTOCOLS
  • 2010-02. The contribution of genetic variation and infection to the pathogenesis of ANCA-associated systemic vasculitis in ARTHRITIS RESEARCH & THERAPY
  • 2010-01. The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes in NATURE GENETICS
  • 2010-01. Genome-wide association study identifies five loci associated with lung function in NATURE GENETICS
  • 2009-12. Follow-up of 1715 SNPs from the Wellcome Trust Case Control Consortium genome-wide association study in type I diabetes families in GENES & IMMUNITY
  • 2009-12. Analysis of 19 genes for association with type I diabetes in the Type I Diabetes Genetics Consortium families in GENES & IMMUNITY
  • 2009-12. Analysis of 55 autoimmune disease and type II diabetes loci: further confirmation of chromosomes 4q27, 12q13.2 and 12q24.13 as type I diabetes loci, and support for a new locus, 12q13.3–q14.1 in GENES & IMMUNITY
  • 2009-12. Confirmation of the genetic association of CTLA4 and PTPN22 with ANCA-associated vasculitis in BMC MEDICAL GENETICS
  • 2009-12. Contrasting genetic association of IL2RAwith SLE and ANCA – associated vasculitis in BMC MEDICAL GENETICS
  • 2009-10. Experimental aspects of copy number variant assays at CCL3L1 in NATURE MEDICINE
  • 2009-10. No association of multiple type 2 diabetes loci with type 1 diabetes in DIABETOLOGIA
  • 2009-09. Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource in NATURE GENETICS
  • 2009-06. Genome-wide association study identifies eight loci associated with blood pressure in NATURE GENETICS
  • 2009-03. Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus in GENES & IMMUNITY
  • 2009-01. CD226 Gly307Ser association with multiple autoimmune diseases in GENES & IMMUNITY
  • 2008-12. Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci in NATURE GENETICS
  • 2008-08. The d subunit plays a central role in human vacuolar H+-ATPases in JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
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