Children's Oncology Group Statistics and Data Center View Homepage


Ontology type: schema:MonetaryGrant     


Grant Info

YEARS

2014-2019

FUNDING AMOUNT

36999499 USD

ABSTRACT

DESCRIPTION (provided by applicant): The Children's Oncology Group (COG) Statistics and Data Center (SDC), collaborates with the COG membership to design, conduct analyze and report the results of clinical trials of the treatment of childhood cancers and associated, laboratory-based, companion studies of the biology of these malignancies. Specifically, COG SDC personnel: Participate in the setting and evaluation of COG research priorities; collaborate in the development of study concepts and protocols. In particular, members of the SDC develop the study's statistical considerations; collaborate in the development and implementation of the study's case- report forms for the Group's clinical data management system; monitor study enrollment and the quality and completeness of study data submission; produce interim reports on study conduct and adverse event experience for the Group membership and protocol-specified interim analyses of study outcomes for the Group's Data and Safety Monitoring Committees; produce final reports of the study results for the Group membership; collaborate with laboratories to link specimen data and high dimensional genomics data with COG clinical and outcome data and to produce analyses of these data for publication; produce Technical Reports, detailing analyses performed for Group abstracts and manuscripts; conduct database and methodological research of relevance to the Group's research; perform CDUS and results reporting; monitor the performance of COG member institutions, producing reports for the Group's Institutional Performance monitoring Committee; provide data derived from COG studies to investigators external to the SDC in accordance with the policies and procedures of the Group; participate in National Clinical Trials Network initiatives and CTEP committees as appropriate. More... »

URL

http://projectreporter.nih.gov/project_info_description.cfm?aid=9479110

Related SciGraph Publications

  • 2019-03-30. Magnetic resonance and computed tomography imaging features of epithelioid sarcoma in children and young adults with pathological and clinical correlation: a report from Children’s Oncology Group study ARST0332 in PEDIATRIC RADIOLOGY
  • 2019-03. Targeting EIF4E signaling with ribavirin in infant acute lymphoblastic leukemia in ONCOGENE
  • 2019-02-28. Treatment of higher risk acute lymphoblastic leukemia in young people (CCG-1961), long-term follow-up: a report from the Children’s Oncology Group in LEUKEMIA
  • 2019-02-27. The Population Pharmacokinetics of High-Dose Methotrexate in Infants with Acute Lymphoblastic Leukemia Highlight the Need for Bedside Individualized Dose Adjustment: A Report from the Children’s Oncology Group in CLINICAL PHARMACOKINETICS
  • 2019-02-13. Genetic mechanisms of primary chemotherapy resistance in pediatric acute myeloid leukemia in LEUKEMIA
  • 2019-02. PAX5-driven subtypes of B-progenitor acute lymphoblastic leukemia in NATURE GENETICS
  • 2018-12. A comparative analysis of clinicopathological features and survival among early adolescents/young adults and children with low-grade glioma: a report from the Children’s Oncology Group in JOURNAL OF NEURO-ONCOLOGY
  • 2018-12. Dysregulated transcriptional networks in KMT2A- and MLLT10-rearranged T-ALL in BIOMARKER RESEARCH
  • 2018-12. Distinct Metabolic features differentiating FLT3-ITD AML from FLT3-WT childhood Acute Myeloid Leukemia in SCIENTIFIC REPORTS
  • 2018-11. Significance of pleural effusion at diagnosis in pediatric Hodgkin lymphoma: a report from Children’s Oncology Group protocol AHOD0031 in PEDIATRIC RADIOLOGY
  • 2018-10. Differences in DNA methylation profiles by histologic subtype of paediatric germ cell tumours: a report from the Children’s Oncology Group in BRITISH JOURNAL OF CANCER
  • 2018-10. Hedgehog pathway mutations drive oncogenic transformation in high-risk T-cell acute lymphoblastic leukemia in LEUKEMIA
  • 2018-10. The genetic basis and cell of origin of mixed phenotype acute leukaemia in NATURE
  • 2018-08. Detection of circulating tumour DNA is associated with inferior outcomes in Ewing sarcoma and osteosarcoma: a report from the Children’s Oncology Group in BRITISH JOURNAL OF CANCER
  • 2018-06. Flow-cytometric vs. -morphologic assessment of remission in childhood acute lymphoblastic leukemia: a report from the Children’s Oncology Group (COG) in LEUKEMIA
  • 2018-02. Validation of the mIBG skeletal SIOPEN scoring method in two independent high-risk neuroblastoma populations: the SIOPEN/HR-NBL1 and COG-A3973 trials in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2018-01. Family history of cancer in children and adolescents with germ cell tumours: a report from the Children’s Oncology Group in BRITISH JOURNAL OF CANCER
  • 2018-01. The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions in NATURE MEDICINE
  • 2017-12. Common variants in MMP20 at 11q22.2 predispose to 11q deletion and neuroblastoma risk in NATURE COMMUNICATIONS
  • 2017-11. Imaging of renal medullary carcinoma in children and young adults: a report from the Children’s Oncology Group in PEDIATRIC RADIOLOGY
  • 2017-10. A Children's Oncology Group and TARGET initiative exploring the genetic landscape of Wilms tumor in NATURE GENETICS
  • 2017-08. The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia in NATURE GENETICS
  • 2017-07. Maternal and paternal occupational exposures and hepatoblastoma: results from the HOPE study through the Children’s Oncology Group in JOURNAL OF EXPOSURE SCIENCE & ENVIRONMENTAL EPIDEMIOLOGY
  • 2017-06. Genetics of ancestry-specific risk for relapse in acute lymphoblastic leukemia in LEUKEMIA
  • 2017-01. Caphosol for prevention of oral mucositis in pediatric myeloablative haematopoietic cell transplantation in BRITISH JOURNAL OF CANCER
  • 2016-12. Potential pitfalls of mass spectrometry to uncover mutations in childhood soft tissue sarcoma: A report from the Children’s Oncology Group in SCIENTIFIC REPORTS
  • 2016-12. Proteasome subunit expression analysis and chemosensitivity in relapsed paediatric acute leukaemia patients receiving bortezomib-containing chemotherapy in JOURNAL OF HEMATOLOGY & ONCOLOGY
  • 2016-12. Rationale and design of the Children’s Oncology Group (COG) study ALTE1621: a randomized, placebo-controlled trial to determine if low-dose carvedilol can prevent anthracycline-related left ventricular remodeling in childhood cancer survivors at high risk for developing heart failure in BMC CARDIOVASCULAR DISORDERS
  • 2016-12. Erratum to: High expression of myocyte enhancer factor 2C (MEF2C) is associated with adverse-risk features and poor outcome in pediatric acute myeloid leukemia: a report from the Children’s Oncology Group in JOURNAL OF HEMATOLOGY & ONCOLOGY
  • 2016-12. Deregulation of DUX4 and ERG in acute lymphoblastic leukemia in NATURE GENETICS
  • 2016-11-08. Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia in NATURE COMMUNICATIONS
  • 2016-10. A recurrent immunophenotype at diagnosis independently identifies high-risk pediatric acute myeloid leukemia: a report from Children’s Oncology Group in LEUKEMIA
  • 2016-10. Local Control Modality and Outcome for Ewing Sarcoma of the Femur: A Report From the Children’s Oncology Group in ANNALS OF SURGICAL ONCOLOGY
  • 2016-10. A family-based study of gene variants and maternal folate and choline in neuroblastoma: a report from the Children’s Oncology Group in CANCER CAUSES & CONTROL
  • 2016-09. MLL rearrangements impact outcome in HOXA-deregulated T-lineage acute lymphoblastic leukemia: a Children’s Oncology Group Study in LEUKEMIA
  • 2016-07. RasGRP1 overexpression in T-ALL increases basal nucleotide exchange on Ras rendering the Ras/PI3K/Akt pathway responsive to protumorigenic cytokines in ONCOGENE
  • 2016-03. Vesicular monoamine transporter protein expression correlates with clinical features, tumor biology, and MIBG avidity in neuroblastoma: a report from the Children’s Oncology Group in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2015-12. High expression of myocyte enhancer factor 2C (MEF2C) is associated with adverse-risk features and poor outcome in pediatric acute myeloid leukemia: a report from the Children’s Oncology Group in JOURNAL OF HEMATOLOGY & ONCOLOGY
  • 2015-12. Ethnic variation of TET2 SNP rs2454206 and association with clinical outcome in childhood AML: a report from the Children’s Oncology Group in LEUKEMIA
  • 2015-11. The genomic landscape of juvenile myelomonocytic leukemia in NATURE GENETICS
  • 2015-09. Risk factors and timing of relapse after allogeneic transplantation in pediatric ALL: for whom and when should interventions be tested? in BONE MARROW TRANSPLANTATION
  • 2015-06. Augmented expression of MYC and/or MYCN protein defines highly aggressive MYC-driven neuroblastoma: a Children’s Oncology Group study in BRITISH JOURNAL OF CANCER
  • 2015-06. Strategies to improve success of pediatric cancer cooperative group quality of life studies: a report from the Children’s Oncology Group in QUALITY OF LIFE RESEARCH
  • 2015-02. Comparison of diagnostic performance of CT and MRI for abdominal staging of pediatric renal tumors: a report from the Children’s Oncology Group in PEDIATRIC RADIOLOGY
  • 2014-12. Childhood cancer survivor care: development of the Passport for Care in NATURE REVIEWS CLINICAL ONCOLOGY
  • 2014-10. Pharmacokinetics and pharmacogenomics of daunorubicin in children: a report from the Children’s Oncology Group in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2014-07. Long-term follow-up of imatinib in pediatric Philadelphia chromosome-positive acute lymphoblastic leukemia: Children's Oncology Group Study AALL0031 in LEUKEMIA
  • 2014-07. Maternal and birth characteristics and childhood rhabdomyosarcoma: a report from the Children’s Oncology Group in CANCER CAUSES & CONTROL
  • 2014-06. Excess congenital non-synonymous variation in leukemia-associated genes in MLL− infant leukemia: a Children’s Oncology Group report in LEUKEMIA
  • 2014-06. Feasibility of Conducting Long-Term Follow-Up of Children and Infants Treated for CNS Tumors on the Same Cooperative Group Clinical Trial Protocol in JOURNAL OF CLINICAL PSYCHOLOGY IN MEDICAL SETTINGS
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