MRC Biomedical NMR Centre View Homepage


Ontology type: schema:MonetaryGrant     


Grant Info

YEARS

1980-2015

FUNDING AMOUNT

5448504 GBP

ABSTRACT

The MRC Biomedical NMR Centre is a multi-user facility providing advanced and well-supported instruments for nuclear magnetic resonance studies of biological macromolecules such as proteins, carbohydrates and nucleic acids. Users of the Centre come from academic institutions across the UK. Technical Summary The purpose of the Centre is to provide well-supported NMR facilities at the forefront of the available technology for use by academic scientists working on NMR-based biological problems. The Centre is used by scientists from various UK colleges, hospitals and institutes, including scientists from the National Institute for Medical Research. In recent years the Centres facilities have been used mainly in studies of structures and dynamic processes of proteins, as well as well as in studies of protein-ligand, protein-DNA and protein-RNA interactions. Several studies of RNA and of complex carbohydrates are also in progress. Access to the Centres facilities is allocated by an expert Advisory Committee.|The Centre is equipped with 800 MHz, 700 MHz, and two 600 MHz spectrometers. The instruments are capable of all modern NMR experiments, including those involving 13C/15N/2H labelled molecules and 3D and 4D spectroscopy. Three of the spectrometers are equipped with cryogenically cooled probes for enhanced sensitivity. Most of the researchers (about 50 in total) operate the equipment themselves, under the guidance of Centre staff. The staff of the Centre also provide expert advice on the design, implementation, and analysis of NMR experiments. |The work carried out at the Centre is mostly basic research aimed at understanding the structural basis of molecular interactions such as those involved in multi-protein complexes. The work is of indirect clinical relevance in that many of the proteins being studied by users of the Centre are of therapeutic interest. More... »

URL

http://gtr.rcuk.ac.uk/project/B36500A1-D3B3-4AD6-9DBB-081765F15642

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