Molecular Genetics of Endocrine Tumors and Related Disorders View Homepage


Ontology type: schema:MonetaryGrant     


Grant Info

YEARS

2012-2017

FUNDING AMOUNT

15177672 USD

ABSTRACT

The goal of this work is to understand the genetic and molecular mechanisms leading to disorders that affect the adrenal cortex, with emphasis on those that are developmental, hereditary and associated with adrenal hypoplasia or hyperplasia, multiple tumors and abnormalities in other endocrine glands (especially the pituitary gland and to a lesser extent the thyroid gland). We have studied congenital adrenal hypoplasia caused by triple A syndrome and other defects, other multiple endocrine deficiencies, familial hyperaldosteronism, adrenocortical and thyroid cancer, pituitary tumors and multiple endocrine neoplasia (MEN) syndromes affecting the pituitary, thyroid and adrenal glands, and Carney complex (CNC), an autosomal dominant disease. CNC is a MEN syndrome affecting the pituitary, adrenal cortex, thyroid, and the gonads, and is associated with a variety of other tumors, including myxomas and schwannomas, and skin pigmentation defects (lentigines, cafe-au-lait spots, and nevi). We have identified the regulatory subunit type 1-A of protein kinase A (PKA), which is coded by the PRKAR1A gene as the gene responsible for most CNC patients. Thus, a significant part of our work is now focused on PKA-stimulated signaling pathways, PKA effects on tumor suppression and/or development, the cell cycle and chromosomal stability. Prkar1a-specific animal models have also been created to address the tumor-promoting effects of this gene and serve as models for possible therapies. In addition, genes that are mutated in patients with CNC-like and other froms of inherited adrenal tumors are being investigated. Most recently, mutations in PRKACA, PRKACB and ARMC5, as well as in phosphodiesterase genes - phosphodiesterase 11A (PDE11A) and PDE8B - were identified in patients with various forms of bilateral adrenocortical hyperplasias. We also identified GPR101 defects and described X-linked acrogigantism (X-LAG) in patients with growth hormone-producing lesions of the pituitary gland. Mouse models with the respective genetic defects are also being studied, and mutations of these genes are being sought in other endocrine tumors. We have also elucidated the causative genetic defects in Carney-Stratakis syndrome (CSS) and we continue our search for genes that are related to tumors that develop in association with CSS and a similar condition (Carney Triad). More... »

URL

http://projectreporter.nih.gov/project_info_description.cfm?aid=9564625

Related SciGraph Publications

  • 2018-12. An update on adrenal endocrinology: significant discoveries in the last 10 years and where the field is heading in the next decade in HORMONES
  • 2018-05. Superiority of 68Ga-DOTATATE over 18F-FDG and anatomic imaging in the detection of succinate dehydrogenase mutation (SDHx)-related pheochromocytoma and paraganglioma in the pediatric population in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2018-02. Decreased lymphocytes and increased risk for infection are common in endogenous pediatric Cushing syndrome in PEDIATRIC RESEARCH
  • 2017-12. Increased glucocorticoid receptor expression in sepsis is related to heat shock proteins, cytokines, and cortisol and is associated with increased mortality in INTENSIVE CARE MEDICINE EXPERIMENTAL
  • 2017-09. Bone mineral density in patients with inherited bone marrow failure syndromes in PEDIATRIC RESEARCH
  • 2017-08. Pediatric Cushing disease: disparities in disease severity and outcomes in the Hispanic and African-American populations in PEDIATRIC RESEARCH
  • 2017-04. Hair cortisol in the evaluation of Cushing syndrome in ENDOCRINE
  • 2017-02. Prospective phenotyping of NGLY1-CDDG, the first congenital disorder of deglycosylation in GENETICS IN MEDICINE
  • 2017. Genetics of Benign Adrenocortical Tumors in MANAGEMENT OF ADRENAL MASSES IN CHILDREN AND ADULTS
  • 2017. Genetic Disorders of Adrenocortical Function in PRINCIPLES OF ENDOCRINOLOGY AND HORMONE ACTION
  • 2017-01. Combined pituitary hormone deficiency in a girl with 48, XXXX and Rathke’s cleft cyst in HORMONES
  • 2016-12. Germline or somatic GPR101 duplication leads to X-linked acrogigantism: a clinico-pathological and genetic study in ACTA NEUROPATHOLOGICA COMMUNICATIONS
  • 2016-10. Benign hormone-secreting adenoma within a larger adrenocortical mass showing intensely increased activity on 18F-FDG PET/CT in ENDOCRINE
  • 2016-09-14. PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development in NATURE COMMUNICATIONS
  • 2016-09. Hereditary syndromes predisposing to endocrine tumors and their skin manifestations in REVIEWS IN ENDOCRINE AND METABOLIC DISORDERS
  • 2016-09. Flushing in (neuro)endocrinology in REVIEWS IN ENDOCRINE AND METABOLIC DISORDERS
  • 2016-09. Metabolism and skin diseases in REVIEWS IN ENDOCRINE AND METABOLIC DISORDERS
  • 2016-09. Carney complex: A familial lentiginosis predisposing to a variety of tumors in REVIEWS IN ENDOCRINE AND METABOLIC DISORDERS
  • 2016-09. Skin steroidogenesis in health and disease in REVIEWS IN ENDOCRINE AND METABOLIC DISORDERS
  • 2016-09. Skin manifestations of Cushing’s syndrome in REVIEWS IN ENDOCRINE AND METABOLIC DISORDERS
  • 2016-07. Cyclopes and Giants: From Homer’s Odyssey to contemporary genetic diagnosis in HORMONES
  • 2016-05. A novel AVPR2 splice site mutation leads to partial X-linked nephrogenic diabetes insipidus in two brothers in EUROPEAN JOURNAL OF PEDIATRICS
  • 2016-05. A genetic and molecular update on adrenocortical causes of Cushing syndrome in NATURE REVIEWS ENDOCRINOLOGY
  • 2016-04. Adrenal malignant melanoma masquerading as a pheochromocytoma in a patient with a history of a multifocal papillary and medullary thyroid carcinoma in HORMONES
  • 2016-04. Carney triad can be (rarely) associated with germline succinate dehydrogenase defects in EUROPEAN JOURNAL OF HUMAN GENETICS
  • 2016-03. FDG PET/CT Scan and Functional Adrenal Tumors: A Pilot Study for Lateralization in WORLD JOURNAL OF SURGERY
  • 2016-02. Aggressive tumor growth and clinical evolution in a patient with X-linked acro-gigantism syndrome in ENDOCRINE
  • 2016-02. 5th International ACC Symposium: The New Genetics of Benign Adrenocortical Neoplasia: Hyperplasias, Adenomas, and Their Implications for Progression into Cancer in HORMONES AND CANCER
  • 2016. Diagnosis and Management of Hereditary Adrenal Cancer in RARE HEREDITARY CANCERS
  • 2016. Genetic Disorders of Adrenocortical Function in PRINCIPLES OF ENDOCRINOLOGY AND HORMONE ACTION
  • 2015-12. Patterns of thyroid hormone levels in pediatric medullary thyroid carcinoma patients on vandetanib therapy in INTERNATIONAL JOURNAL OF PEDIATRIC ENDOCRINOLOGY
  • 2015-12. SASH1 Is Involved in an Autosomal Dominant Lentiginous Phenotype in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2015-12. Hematopoietic neoplasms in Prkar2a-deficient mice in JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
  • 2015-12. Long-Term Outcome of Bilateral Laparoscopic Adrenalectomy Measured by Disease-Specific Questionnaire in a Unique Group of Patients with Cushing’s Syndrome in ANNALS OF SURGICAL ONCOLOGY
  • 2015-12. Residual manifestations of hypercortisolemia following surgical treatment in a patient with Cushing syndrome in INTERNATIONAL JOURNAL OF PEDIATRIC ENDOCRINOLOGY
  • 2015-11. A giant? Think of genetics: growth hormone-producing adenomas in the young are almost always the result of genetic defects in ENDOCRINE
  • 2015-10-25. Identification of a novel mutation of the PRKAR1A gene in a patient with Carney complex with significant osteoporosis and recurrent fractures. in HORMONES
  • 2015-09. Phosphodiesterase 8B and cyclic AMP signaling in the adrenal cortex in ENDOCRINE
  • 2015-07. McCune Albright syndrome and bilateral adrenal hyperplasia: the GNAS mutation may only be present in adrenal tissue in HORMONES
  • 2015-04. Death in pediatric Cushing syndrome is uncommon but still occurs in EUROPEAN JOURNAL OF PEDIATRICS
  • 2014-12. The size of the primary tumor and age at initial diagnosis are independent predictors of the metastatic behavior and survival of patients with SDHB-related pheochromocytoma and paraganglioma: a retrospective cohort study in BMC CANCER
  • 2014-11. The genetic landscape of gastrointestinal stromal tumor lacking KIT and PDGFRA mutations in ENDOCRINE
  • 2014-02. Adrenal cancer in 2013: Time to individualize treatment for adrenocortical cancer? in NATURE REVIEWS ENDOCRINOLOGY
  • 2013-03. Adrenal Histologic Findings Show No Difference in Clinical Presentation and Outcome in Primary Hyperaldosteronism in ANNALS OF SURGICAL ONCOLOGY
  • 2013-03. An update on the genetics of pheochromocytoma in JOURNAL OF HUMAN HYPERTENSION
  • 2013-03. Functional screen analysis reveals miR-26b and miR-128 as central regulators of pituitary somatomammotrophic tumor growth through activation of the PTEN–AKT pathway in ONCOGENE
  • 2013-02. Comprehensive Analysis of LC/MS Data Using Pseudocolor Plots in JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
  • 2013-02. The complex of myxomas, spotty skin pigmentation and endocrine overactivity (Carney complex): imaging findings with clinical and pathological correlation in INSIGHTS INTO IMAGING
  • 2012-08. Ultra-structural identification of interstitial cells of Cajal in the zebrafish Danio rerio in CELL AND TISSUE RESEARCH
  • 2012-06. What is the Best Criterion for the Interpretation of Adrenal Vein Sample Results in Patients with Primary Hyperaldosteronism? in ANNALS OF SURGICAL ONCOLOGY
  • JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/2206", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "type": "DefinedTerm"
          }
        ], 
        "amount": {
          "currency": "USD", 
          "type": "MonetaryAmount", 
          "value": "15177672"
        }, 
        "description": "The goal of this work is to understand the genetic and molecular mechanisms leading to disorders that affect the adrenal cortex, with emphasis on those that are developmental, hereditary and associated with adrenal hypoplasia or hyperplasia, multiple tumors and abnormalities in other endocrine glands (especially the pituitary gland and to a lesser extent the thyroid gland). We have studied congenital adrenal hypoplasia caused by triple A syndrome and other defects, other multiple endocrine deficiencies, familial hyperaldosteronism, adrenocortical and thyroid cancer, pituitary tumors and multiple endocrine neoplasia (MEN) syndromes affecting the pituitary, thyroid and adrenal glands, and Carney complex (CNC), an autosomal dominant disease. CNC is a MEN syndrome affecting the pituitary, adrenal cortex, thyroid, and the gonads, and is associated with a variety of other tumors, including myxomas and schwannomas, and skin pigmentation defects (lentigines, cafe-au-lait spots, and nevi). We have identified the regulatory subunit type 1-A of protein kinase A (PKA), which is coded by the PRKAR1A gene as the gene responsible for most CNC patients. Thus, a significant part of our work is now focused on PKA-stimulated signaling pathways, PKA effects on tumor suppression and/or development, the cell cycle and chromosomal stability. Prkar1a-specific animal models have also been created to address the tumor-promoting effects of this gene and serve as models for possible therapies. In addition, genes that are mutated in patients with CNC-like and other froms of inherited adrenal tumors are being investigated. Most recently, mutations in PRKACA, PRKACB and ARMC5, as well as in phosphodiesterase genes - phosphodiesterase 11A (PDE11A) and PDE8B - were identified in patients with various forms of bilateral adrenocortical hyperplasias. We also identified GPR101 defects and described X-linked acrogigantism (X-LAG) in patients with growth hormone-producing lesions of the pituitary gland. Mouse models with the respective genetic defects are also being studied, and mutations of these genes are being sought in other endocrine tumors. We have also elucidated the causative genetic defects in Carney-Stratakis syndrome (CSS) and we continue our search for genes that are related to tumors that develop in association with CSS and a similar condition (Carney Triad).", 
        "endDate": "2017-01-01T00:00:00Z", 
        "funder": {
          "id": "https://www.grid.ac/institutes/grid.420089.7", 
          "type": "Organization"
        }, 
        "id": "sg:grant.2725681", 
        "identifier": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "2725681"
            ]
          }, 
          {
            "name": "nih_id", 
            "type": "PropertyValue", 
            "value": [
              "ZIAHD008920"
            ]
          }
        ], 
        "inLanguage": [
          "en"
        ], 
        "keywords": [
          "other endocrine glands", 
          "chromosomal stability", 
          "cafe-au-lait spots", 
          "variety", 
          "PRKACA", 
          "addition", 
          "multiple tumors", 
          "disorders", 
          "Carney", 
          "other defects", 
          "PKA", 
          "development", 
          "adrenal cortex", 
          "pituitary tumors", 
          "CNC", 
          "other multiple endocrine deficiencies", 
          "PDE11A", 
          "lesions", 
          "PRKACB", 
          "regulatory subunit type 1-A", 
          "PKA effect", 
          "abnormalities", 
          "work", 
          "bilateral adrenocortical hyperplasias", 
          "PDE8B", 
          "schwannoma", 
          "syndrome", 
          "specific animal models", 
          "goal", 
          "adrenal tumors", 
          "cell cycle", 
          "autosomal dominant disease", 
          "lentigines", 
          "tumor suppression", 
          "Molecular Genetics", 
          "myxoma", 
          "pathway", 
          "congenital adrenal hypoplasia", 
          "most CNC patients", 
          "Carney-Stratakis syndrome", 
          "growth hormone", 
          "lesser extent", 
          "mutations", 
          "molecular mechanisms", 
          "triple", 
          "phosphodiesterase genes - phosphodiesterase 11A", 
          "genes", 
          "mouse model", 
          "Endocrine Tumors", 
          "thyroid", 
          "nevi", 
          "other tumors", 
          "ARMC5", 
          "causative genetic defects", 
          "association", 
          "MEN syndromes", 
          "familial hyperaldosteronism", 
          "Related Disorders", 
          "pituitary gland", 
          "adrenal hypoplasia", 
          "similar conditions", 
          "hyperplasia", 
          "gonads", 
          "patients", 
          "effect", 
          "PRKAR1A gene", 
          "possible therapy", 
          "other froms", 
          "significant part", 
          "skin pigmentation defects", 
          "various forms", 
          "emphasis", 
          "Carney triad", 
          "thyroid cancer", 
          "thyroid gland", 
          "protein", 
          "search", 
          "respective genetic defects", 
          "multiple endocrine neoplasia", 
          "model", 
          "adrenal gland", 
          "defects", 
          "other endocrine tumors", 
          "pituitary", 
          "acrogigantism", 
          "lag", 
          "tumor"
        ], 
        "name": "Molecular Genetics of Endocrine Tumors and Related Disorders", 
        "recipient": [
          {
            "id": "https://www.grid.ac/institutes/grid.420089.7", 
            "type": "Organization"
          }, 
          {
            "affiliation": {
              "id": "https://www.grid.ac/institutes/grid.420089.7", 
              "name": "CHILD HEALTH AND HUMAN DEVELOPMENT", 
              "type": "Organization"
            }, 
            "familyName": "STRATAKIS", 
            "givenName": "CONSTANTINE A.", 
            "id": "sg:person.011151216517.08", 
            "type": "Person"
          }, 
          {
            "member": "sg:person.011151216517.08", 
            "roleName": "PI", 
            "type": "Role"
          }
        ], 
        "sameAs": [
          "https://app.dimensions.ai/details/grant/grant.2725681"
        ], 
        "sdDataset": "grants", 
        "sdDatePublished": "2021-01-20T03:00", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com.uberresearch.data.processor/core_data/20181219_192338/projects/base/nih_projects_22.xml.gz", 
        "startDate": "2012-01-01T00:00:00Z", 
        "type": "MonetaryGrant", 
        "url": "http://projectreporter.nih.gov/project_info_description.cfm?aid=9564625"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/grant.2725681'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/grant.2725681'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/grant.2725681'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/grant.2725681'


     

    This table displays all metadata directly associated to this object as RDF triples.

    130 TRIPLES      19 PREDICATES      108 URIs      101 LITERALS      5 BLANK NODES

    Subject Predicate Object
    1 sg:grant.2725681 schema:about anzsrc-for:2206
    2 schema:amount Na6a9a6b20ac94ef28760654f9c49bc0c
    3 schema:description The goal of this work is to understand the genetic and molecular mechanisms leading to disorders that affect the adrenal cortex, with emphasis on those that are developmental, hereditary and associated with adrenal hypoplasia or hyperplasia, multiple tumors and abnormalities in other endocrine glands (especially the pituitary gland and to a lesser extent the thyroid gland). We have studied congenital adrenal hypoplasia caused by triple A syndrome and other defects, other multiple endocrine deficiencies, familial hyperaldosteronism, adrenocortical and thyroid cancer, pituitary tumors and multiple endocrine neoplasia (MEN) syndromes affecting the pituitary, thyroid and adrenal glands, and Carney complex (CNC), an autosomal dominant disease. CNC is a MEN syndrome affecting the pituitary, adrenal cortex, thyroid, and the gonads, and is associated with a variety of other tumors, including myxomas and schwannomas, and skin pigmentation defects (lentigines, cafe-au-lait spots, and nevi). We have identified the regulatory subunit type 1-A of protein kinase A (PKA), which is coded by the PRKAR1A gene as the gene responsible for most CNC patients. Thus, a significant part of our work is now focused on PKA-stimulated signaling pathways, PKA effects on tumor suppression and/or development, the cell cycle and chromosomal stability. Prkar1a-specific animal models have also been created to address the tumor-promoting effects of this gene and serve as models for possible therapies. In addition, genes that are mutated in patients with CNC-like and other froms of inherited adrenal tumors are being investigated. Most recently, mutations in PRKACA, PRKACB and ARMC5, as well as in phosphodiesterase genes - phosphodiesterase 11A (PDE11A) and PDE8B - were identified in patients with various forms of bilateral adrenocortical hyperplasias. We also identified GPR101 defects and described X-linked acrogigantism (X-LAG) in patients with growth hormone-producing lesions of the pituitary gland. Mouse models with the respective genetic defects are also being studied, and mutations of these genes are being sought in other endocrine tumors. We have also elucidated the causative genetic defects in Carney-Stratakis syndrome (CSS) and we continue our search for genes that are related to tumors that develop in association with CSS and a similar condition (Carney Triad).
    4 schema:endDate 2017-01-01T00:00:00Z
    5 schema:funder https://www.grid.ac/institutes/grid.420089.7
    6 schema:identifier N66a9d426c80d451189cccccde36bb453
    7 N7886c146a9cf43c58bfaa285c583df24
    8 schema:inLanguage en
    9 schema:keywords ARMC5
    10 CNC
    11 Carney
    12 Carney triad
    13 Carney-Stratakis syndrome
    14 Endocrine Tumors
    15 MEN syndromes
    16 Molecular Genetics
    17 PDE11A
    18 PDE8B
    19 PKA
    20 PKA effect
    21 PRKACA
    22 PRKACB
    23 PRKAR1A gene
    24 Related Disorders
    25 abnormalities
    26 acrogigantism
    27 addition
    28 adrenal cortex
    29 adrenal gland
    30 adrenal hypoplasia
    31 adrenal tumors
    32 association
    33 autosomal dominant disease
    34 bilateral adrenocortical hyperplasias
    35 cafe-au-lait spots
    36 causative genetic defects
    37 cell cycle
    38 chromosomal stability
    39 congenital adrenal hypoplasia
    40 defects
    41 development
    42 disorders
    43 effect
    44 emphasis
    45 familial hyperaldosteronism
    46 genes
    47 goal
    48 gonads
    49 growth hormone
    50 hyperplasia
    51 lag
    52 lentigines
    53 lesions
    54 lesser extent
    55 model
    56 molecular mechanisms
    57 most CNC patients
    58 mouse model
    59 multiple endocrine neoplasia
    60 multiple tumors
    61 mutations
    62 myxoma
    63 nevi
    64 other defects
    65 other endocrine glands
    66 other endocrine tumors
    67 other froms
    68 other multiple endocrine deficiencies
    69 other tumors
    70 pathway
    71 patients
    72 phosphodiesterase genes - phosphodiesterase 11A
    73 pituitary
    74 pituitary gland
    75 pituitary tumors
    76 possible therapy
    77 protein
    78 regulatory subunit type 1-A
    79 respective genetic defects
    80 schwannoma
    81 search
    82 significant part
    83 similar conditions
    84 skin pigmentation defects
    85 specific animal models
    86 syndrome
    87 thyroid
    88 thyroid cancer
    89 thyroid gland
    90 triple
    91 tumor
    92 tumor suppression
    93 variety
    94 various forms
    95 work
    96 schema:name Molecular Genetics of Endocrine Tumors and Related Disorders
    97 schema:recipient N0e279c8809194f8f86863f5779843364
    98 sg:person.011151216517.08
    99 https://www.grid.ac/institutes/grid.420089.7
    100 schema:sameAs https://app.dimensions.ai/details/grant/grant.2725681
    101 schema:sdDatePublished 2021-01-20T03:00
    102 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    103 schema:sdPublisher N480864f714bc484bac7ba5ec03ad1f27
    104 schema:startDate 2012-01-01T00:00:00Z
    105 schema:url http://projectreporter.nih.gov/project_info_description.cfm?aid=9564625
    106 sgo:license sg:explorer/license/
    107 sgo:sdDataset grants
    108 rdf:type schema:MonetaryGrant
    109 N0e279c8809194f8f86863f5779843364 schema:member sg:person.011151216517.08
    110 schema:roleName PI
    111 rdf:type schema:Role
    112 N480864f714bc484bac7ba5ec03ad1f27 schema:name Springer Nature - SN SciGraph project
    113 rdf:type schema:Organization
    114 N66a9d426c80d451189cccccde36bb453 schema:name dimensions_id
    115 schema:value 2725681
    116 rdf:type schema:PropertyValue
    117 N7886c146a9cf43c58bfaa285c583df24 schema:name nih_id
    118 schema:value ZIAHD008920
    119 rdf:type schema:PropertyValue
    120 Na6a9a6b20ac94ef28760654f9c49bc0c schema:currency USD
    121 schema:value 15177672
    122 rdf:type schema:MonetaryAmount
    123 anzsrc-for:2206 schema:inDefinedTermSet anzsrc-for:
    124 rdf:type schema:DefinedTerm
    125 sg:person.011151216517.08 schema:affiliation https://www.grid.ac/institutes/grid.420089.7
    126 schema:familyName STRATAKIS
    127 schema:givenName CONSTANTINE A.
    128 rdf:type schema:Person
    129 https://www.grid.ac/institutes/grid.420089.7 schema:name CHILD HEALTH AND HUMAN DEVELOPMENT
    130 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...