National Center for Biomedical Ontology View Homepage


Ontology type: schema:MonetaryGrant     


Grant Info

YEARS

2005-2017

FUNDING AMOUNT

36159079 USD

ABSTRACT

DESCRIPTION (PROVIDED BY APPLICANT): We propose to continue the National Center for Biomedical Ontology (NCBO), which develops tools and methods for assimilating, archiving, accessing, and applying machine-processable representations of biomedical domain objects, processes, and relations to assist in the management, integration, visualization, analysis, and interpretation of the huge, distributed data sets that are now the hallmark of biomedical research and clinical care. Our center is truly national in scope, with participation of leading scientific groups at Stanford, Mayo Clinic, University at Buffalo, and the University of Victoria. Our objectives are defined by the following six Cores: (1) the development of enhanced computational methods for management of ontologies and controlled terminologies using current Web standards; integration of ontology authoring, publishing, and peer review; creation of a comprehensive ontology-based index of publicly available data resources; development of new analytic methods to summarize and profile biomedical data; (2) the promotion of Driving Biological Projects that can stimulate our research by suggesting new requirements and offering new test beds for deployment-initially involving the Cardiovascular Research Grid, the Rat Genome Database, the caNanoLab nanoparticle database, and the i2b2 National Center for Biomedical Computing, and later engaging the WHO's development of lCD-11, studies performed by ArrayExpress, and projects that will be selected via open requests for applications; (3) the maintenance of a computational infrastructure to support our research, development, and dissemination activities; provision of user support to the growing number of researchers and clinicians who use our technologies; (4) the training of the next generation of scientists in biomedical ontology; (5) a comprehensive set of dissemination activities, that include workshops, tutorials. Web-based seminars, and a major international conference; and (6) outstanding project administration conducted by a dedicated and talented management team. The NCBO will accelerate the transition of biomedicine into the world of e-science, facilitate the creation of a National Health Information Infrastructure, and extend a network of collaboration through its interactions with other NCBCs, with other research consortia, and with the biomedical community at large. More... »

URL

http://projectreporter.nih.gov/project_info_description.cfm?aid=8737919

Related SciGraph Publications

  • 2019-02-19. The variable quality of metadata about biological samples used in biomedical experiments in SCIENTIFIC DATA
  • 2017-12. NCBO Ontology Recommender 2.0: an enhanced approach for biomedical ontology recommendation in JOURNAL OF BIOMEDICAL SEMANTICS
  • 2017-11-02. A high-throughput in vivo screening method in the mouse for identifying regulators of metastatic colonization in NATURE PROTOCOLS
  • 2017-10-04. The CEDAR Workbench: An Ontology-Assisted Environment for Authoring Metadata that Describe Scientific Experiments in THE SEMANTIC WEB – ISWC 2017
  • 2017-09-12. Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation in SCIENTIFIC DATA
  • 2017-01. Genome-wide in vivo screen identifies novel host regulators of metastatic colonization in NATURE
  • 2017. BiOnIC: A Catalog of User Interactions with Biomedical Ontologies in THE SEMANTIC WEB – ISWC 2017
  • 2016-12. Webulous and the Webulous Google Add-On - a web service and application for ontology building from templates in JOURNAL OF BIOMEDICAL SEMANTICS
  • 2016. An Open Repository Model for Acquiring Knowledge About Scientific Experiments in KNOWLEDGE ENGINEERING AND KNOWLEDGE MANAGEMENT
  • 2016-01. Feasibility of Prioritizing Drug–Drug-Event Associations Found in Electronic Health Records in DRUG SAFETY
  • 2015-01. Comment on: “Zoo or Savannah? Choice of Training Ground for Evidence-Based Pharmacovigilance” in DRUG SAFETY
  • 2014-11-11. A time-indexed reference standard of adverse drug reactions in SCIENTIFIC DATA
  • 2014-10. Text Mining for Adverse Drug Events: the Promise, Challenges, and State of the Art in DRUG SAFETY
  • 2014-09-16. Building the graph of medicine from millions of clinical narratives in SCIENTIFIC DATA
  • 2014-08. Toward Enhanced Pharmacovigilance Using Patient‐Generated Data on the Internet in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2014-05. In silico comparative characterization of pharmacogenomic missense variants in BMC GENOMICS
  • 2014-01. MutPred Splice: machine learning-based prediction of exonic variants that disrupt splicing in GENOME BIOLOGY
  • 2013-12. STOP using just GO: a multi-ontology hypothesis generation tool for high throughput experimentation in BMC BIOINFORMATICS
  • 2013-12. ISA-TAB-Nano: A Specification for Sharing Nanomaterial Research Data in Spreadsheet-based Format in BMC BIOTECHNOLOGY
  • 2013-12. The neurological disease ontology in JOURNAL OF BIOMEDICAL SEMANTICS
  • 2013-12. The environment ontology: contextualising biological and biomedical entities in JOURNAL OF BIOMEDICAL SEMANTICS
  • 2013-12. Profiling risk factors for chronic uveitis in juvenile idiopathic arthritis: a new model for EHR-based research in PEDIATRIC RHEUMATOLOGY
  • 2013-12. Mining the ultimate phenome repository in NATURE BIOTECHNOLOGY
  • 2013-09. A Linked Science investigation: enhancing climate change data discovery with semantic technologies in EARTH SCIENCE INFORMATICS
  • 2013-06. Performance of Pharmacovigilance Signal‐Detection Algorithms for the FDA Adverse Event Reporting System in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2013-06. Pharmacovigilance Using Clinical Notes in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2013-04. NCBO Technology: Powering semantically aware applications in JOURNAL OF BIOMEDICAL SEMANTICS
  • 2013-03. A large-scale evaluation of computational protein function prediction in NATURE METHODS
  • 2012-12. Functional organization and its implication in evolution of the human protein-protein interaction network in BMC GENOMICS
  • 2012-12. MicroRNA-centric measurement improves functional enrichment analysis of co-expressed and differentially expressed microRNA clusters in BMC GENOMICS
  • 2012-12. Annotation Analysis for Testing Drug Safety Signals using Unstructured Clinical Notes in JOURNAL OF BIOMEDICAL SEMANTICS
  • 2012-12. Collaborative software for traditional and translational research in HUMAN GENOMICS
  • 2012-09-23. Comprehensive molecular portraits of human breast tumours in NATURE
  • 2012-06. Nanoinformatics: developing new computing applications for nanomedicine in COMPUTING
  • 2012-06. Novel Data‐Mining Methodologies for Adverse Drug Event Discovery and Analysis in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2012-06. Bioinformatics advances in saliva diagnostics in INTERNATIONAL JOURNAL OF ORAL SCIENCE
  • 2012-02. Developing predictive molecular maps of human disease through community-based modeling in NATURE GENETICS
  • 2011-12. How orthogonal are the OBO Foundry ontologies? in JOURNAL OF BIOMEDICAL SEMANTICS
  • 2011-12. Integration and publication of heterogeneous text-mined relationships on the Semantic Web in JOURNAL OF BIOMEDICAL SEMANTICS
  • 2011-12. The representation of protein complexes in the Protein Ontology (PRO) in BMC BIOINFORMATICS
  • 2011-12. HyQue: evaluating hypotheses using Semantic Web technologies in JOURNAL OF BIOMEDICAL SEMANTICS
  • 2011-12. Mapping between the OBO and OWL ontology languages in JOURNAL OF BIOMEDICAL SEMANTICS
  • 2010-12. Saliva Ontology: An ontology-based framework for a Salivaomics Knowledge Base in BMC BIOINFORMATICS
  • 2010-12. Foundations for a realist ontology of mental disease in JOURNAL OF BIOMEDICAL SEMANTICS
  • 2010-09. The BioPAX community standard for pathway data sharing in NATURE BIOTECHNOLOGY
  • 2010-06. Building a biomedical ontology recommender web service in JOURNAL OF BIOMEDICAL SEMANTICS
  • 2010. Meeting Report from the Second “Minimum Information for Biological and Biomedical Investigations” (MIBBI) workshop in STANDARDS IN GENOMIC SCIENCES
  • 2010-01. Integrating phenotype ontologies across multiple species in GENOME BIOLOGY
  • 2009-12. Survey-based naming conventions for use in OBO Foundry ontology development in BMC BIOINFORMATICS
  • 2009-12. An improved ontological representation of dendritic cells as a paradigm for all cell types in BMC BIOINFORMATICS
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