Harvard Transdisciplinary Research in Energetics and Cancer Center View Homepage


Ontology type: schema:MonetaryGrant     


Grant Info

YEARS

2011-2017

FUNDING AMOUNT

9590078 USD

ABSTRACT

In response to the National Cancer Institute re-issue of the Transdisciplinary Research on Energetics and Cancer (TREC) initiative (RFA-CA-10-006), we propose to establish a TREC Center that draws on the multidisciplinary expertise of the faculty of Harvard University at the Harvard School of Public Health (HSPH), Harvard Medical School and the Harvard-affiliated Brigham and Women's Hospital, Boston Children's Hospital, Dana-Farber/Harvard Cancer Center, Harvard Pilgrim Health Care Institute, and the Harvard Center for Population and Development Studies. We have developed four complementary and interrelated research projects which are supported by four cores and additional existing resources at the participating institutions. Together, they form a cohesive, transdisciplinary center focused on the generation of new knowledge and its translation, training, and career development. In Project 1, we will examine sleep duration, energy balance, and insulin resistance among children in Project Viva; in Project 2, we will examine the relation of energetic factors (including dietary insulin demand, objectively measured energy expenditure, and physical activity), sleep duration, and the built environment with novel cancer biomarkers (insulin-IGF axis, adipokines, and sex hormones) in the Nurses' Health Study; in Project 3, we will examine the relation of energetic factors (dietary insulin demand, adiposity, and physical activity) and biomarkers of the insulin/IGF pathway with prostate cancer survivorship in the Physicians' Health Study; and in Project 4, we will conduct a randomized trial to evaluate whether a theory-based exercise intervention, alone or in combination with a pharmacological intervention, decreases circulating levels of insulin and other biomarkers previously linked to poor prognosis among colorectal cancer survivors. These projects will be supported by four cores: Administrative, Education/Training, Bioinformatics, and Developmental. Through these highly integrated projects and supporting Cores, we aim to train postdoctoral fellows and junior faculty in a transdisciplinary environment to pursue careers in energetics and cancer and to foster innovative transdisciplinary research projects that build on the Center's and the overall TREC program's vision and resources. We have obtained strong institutional commitment, as outlined in the letters from Dr. Julio Frenk, Dean of the Faculty, Harvard School of Public Health, and Dr. Edward Benz, Director of the DF/HCC and President of the Dana-Farber Cancer Institute. By leveraging multiple areas of expertise and different resources within and across TREC centers, we can help further build a unique national resource of energetics and cancer knowledge. More... »

URL

http://projectreporter.nih.gov/project_info_description.cfm?aid=8880135

Related SciGraph Publications

  • 2018-07. Lifestyle of women before pregnancy and the risk of offspring obesity during childhood through early adulthood in INTERNATIONAL JOURNAL OF OBESITY
  • 2018-01. Long-term patterns of fasting blood glucose levels and pancreatic cancer incidence in CANCER CAUSES & CONTROL
  • 2017-02. Diet-dependent acid load and type 2 diabetes: pooled results from three prospective cohort studies in DIABETOLOGIA
  • 2017-01. Splicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans in NATURE
  • 2016-09. Blood fatty acid patterns are associated with prostate cancer risk in a prospective nested case–control study in CANCER CAUSES & CONTROL
  • 2016-07. Nut consumption and prostate cancer risk and mortality in BRITISH JOURNAL OF CANCER
  • 2016-03. Nut consumption and risk of colorectal cancer in women in EUROPEAN JOURNAL OF CLINICAL NUTRITION
  • 2016-01. Long-term changes in sleep duration, energy balance and risk of type 2 diabetes in DIABETOLOGIA
  • 2016-01. Vegetarian Diets and Weight Reduction: a Meta-Analysis of Randomized Controlled Trials in JOURNAL OF GENERAL INTERNAL MEDICINE
  • 2015-07. Objective measures are complementary to, rather than a replacement for, self-reported methods in INTERNATIONAL JOURNAL OF OBESITY
  • 2015-07. The Epidemiology of Obesity: A Big Picture in PHARMACOECONOMICS
  • 2015-04. Short-term weight gain and breast cancer risk by hormone receptor classification among pre- and postmenopausal women in BREAST CANCER RESEARCH AND TREATMENT
  • 2014-12. Asian-White disparities in short sleep duration by industry of employment and occupation in the US: a cross-sectional study in BMC PUBLIC HEALTH
  • 2014-12. Urinary concentrations of bisphenol A and phthalate metabolites and weight change: a prospective investigation in US women in INTERNATIONAL JOURNAL OF OBESITY
  • 2014-01. Association between alcohol consumption and plasma fetuin-A and its contribution to incident type 2 diabetes in women in DIABETOLOGIA
  • 2014-01. Body-Mass Index and All-Cause Mortality in US Adults With and Without Diabetes in JOURNAL OF GENERAL INTERNAL MEDICINE
  • 2013-12. Effect of bariatric surgery on oncologic outcomes: a systematic review and meta-analysis in SURGICAL ENDOSCOPY
  • 2013-11. Nut consumption and risk of pancreatic cancer in women in BRITISH JOURNAL OF CANCER
  • 2013-10. Changes in water and beverage intake and long-term weight changes: results from three prospective cohort studies in INTERNATIONAL JOURNAL OF OBESITY
  • 2013-10. Sleep and its Relationship to Racial and Ethnic Disparities in Cardiovascular Disease in CURRENT CARDIOVASCULAR RISK REPORTS
  • 2013-04. Intake of specific fruits and vegetables in relation to risk of estrogen receptor-negative breast cancer among postmenopausal women in BREAST CANCER RESEARCH AND TREATMENT
  • 2013-04. The 2011–2016 Transdisciplinary Research on Energetics and Cancer (TREC) Initiative: Rationale and Design in CANCER CAUSES & CONTROL
  • 2012-06. A dietary pattern that is associated with C-peptide and risk of colorectal cancer in women in CANCER CAUSES & CONTROL
  • 2012-04. A dietary pattern derived to correlate with estrogens and risk of postmenopausal breast cancer in BREAST CANCER RESEARCH AND TREATMENT
  • 2011-03. Cohorts and consortia conference: a summary report (Banff, Canada, June 17–19, 2009) in CANCER CAUSES & CONTROL
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