Mount Sinai Regional Drug Induced Liver Injury Network Site View Homepage


Ontology type: schema:MonetaryGrant     


Grant Info

YEARS

2013-2023

FUNDING AMOUNT

2005978 USD

ABSTRACT

The Drug Induced Liver Injury Network (DILIN), sponsored by NIDDK was established in 2003 to identify cases of DILI across a diverse demographic and geographic spectrum. Mount Sinai has been an integral part of the DILIN since 2013 and helped the network increase recruitment such that patient accrual now exceeds expectations. The current 6 clinical sites have performed very well, with Mount Sinai among the leading enrolling sites, particularly for acute DILI cases. The integration of several new hospitals to the Mount Sinai Health System and formation of a Liver Institute to organize hepatology care across the health system will likely result in an increase in enrollment from the Mount Sinai DILIN site with added ethnic diversity. As a whole, the DILIN is well positioned to embark on important goals: continuing to recruit patients early in the course of illness to identify DILI biomarkers; increase the racial/ethnic diversity of patients in the prospective cohort by focused recruitment in urban areas; enrollment of herbal and dietary supplement (HDS) cases along with analysis of HDS products collected in the repository; setting up systems for early detection of drugs or HDS associated with DILI to assist regulatory authorities; and continuing to provide accurate clinical information about DILI through published literature and support for the Livertox website. The Specific Aims for the Mount Sinai site are as follows: 1) To enroll adults and children with DILI in the current DILIN prospective and retrospective databases; 2) To specifically enroll patients early in the course of suspected DILI; 3) To enrich the current DILIN prospective and retrospective databases with patients of non-Caucasian ethnicity; 4) To evaluate serum and genetic biomarkers for chemotherapy-induced liver injury and determine if melatonin pretreatment prevents chemotherapy-induced liver injury; and 5) To rapidly identify newly approved prescription medications and new HDS formulations that cause unexpected concentrations of DILI cases. More... »

URL

http://projectreporter.nih.gov/project_info_description.cfm?aid=9608483

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/2211", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }
    ], 
    "amount": {
      "currency": "USD", 
      "type": "MonetaryAmount", 
      "value": "2005978"
    }, 
    "description": "The Drug Induced Liver Injury Network (DILIN), sponsored by NIDDK was established in 2003 to identify cases of DILI across a diverse demographic and geographic spectrum. Mount Sinai has been an integral part of the DILIN since 2013 and helped the network increase recruitment such that patient accrual now exceeds expectations. The current 6 clinical sites have performed very well, with Mount Sinai among the leading enrolling sites, particularly for acute DILI cases. The integration of several new hospitals to the Mount Sinai Health System and formation of a Liver Institute to organize hepatology care across the health system will likely result in an increase in enrollment from the Mount Sinai DILIN site with added ethnic diversity. As a whole, the DILIN is well positioned to embark on important goals: continuing to recruit patients early in the course of illness to identify DILI biomarkers; increase the racial/ethnic diversity of patients in the prospective cohort by focused recruitment in urban areas; enrollment of herbal and dietary supplement (HDS) cases along with analysis of HDS products collected in the repository; setting up systems for early detection of drugs or HDS associated with DILI to assist regulatory authorities; and continuing to provide accurate clinical information about DILI through published literature and support for the Livertox website. The Specific Aims for the Mount Sinai site are as follows: 1) To enroll adults and children with DILI in the current DILIN prospective and retrospective databases; 2) To specifically enroll patients early in the course of suspected DILI; 3) To enrich the current DILIN prospective and retrospective databases with patients of non-Caucasian ethnicity; 4) To evaluate serum and genetic biomarkers for chemotherapy-induced liver injury and determine if melatonin pretreatment prevents chemotherapy-induced liver injury; and 5) To rapidly identify newly approved prescription medications and new HDS formulations that cause unexpected concentrations of DILI cases.", 
    "endDate": "2023-06-30T00:00:00Z", 
    "funder": {
      "id": "https://www.grid.ac/institutes/grid.419635.c", 
      "type": "Organization"
    }, 
    "id": "sg:grant.2690338", 
    "identifier": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "2690338"
        ]
      }, 
      {
        "name": "nih_id", 
        "type": "PropertyValue", 
        "value": [
          "U01DK100928"
        ]
      }
    ], 
    "inLanguage": [
      "en"
    ], 
    "keywords": [
      "NIDDK", 
      "ethnic diversity", 
      "HDS", 
      "whole", 
      "illness", 
      "accurate clinical information", 
      "Mount Sinai Regional Drug Induced Liver Injury Network Site", 
      "hepatology care", 
      "analysis", 
      "melatonin pretreatment", 
      "urban areas", 
      "formation", 
      "recruitment", 
      "Liver Institute", 
      "increase", 
      "Livertox website", 
      "several new hospitals", 
      "early detection", 
      "important goal", 
      "chemotherapy", 
      "children", 
      "regulatory authorities", 
      "genetic biomarkers", 
      "drugs", 
      "Mount Sinai", 
      "DILI cases", 
      "Mount Sinai Health System", 
      "prescription medications", 
      "current DILIN", 
      "patients", 
      "geographic spectrum", 
      "DILI", 
      "support", 
      "clinical sites", 
      "Mount Sinai site", 
      "non-Caucasian ethnicity", 
      "prospective cohort", 
      "focused recruitment", 
      "sites", 
      "integral part", 
      "enrollment", 
      "course", 
      "health system", 
      "cases", 
      "new HDS formulations", 
      "unexpected concentration", 
      "Drug Induced Liver Injury Network", 
      "acute DILI cases", 
      "retrospective database", 
      "dietary supplements", 
      "integration", 
      "expectations", 
      "Specific Aims", 
      "system", 
      "network", 
      "repository", 
      "adults", 
      "liver injury", 
      "HDS products", 
      "serum", 
      "literature", 
      "DILI biomarkers", 
      "Mount Sinai DILIN site"
    ], 
    "name": "Mount Sinai Regional Drug Induced Liver Injury Network Site", 
    "recipient": [
      {
        "id": "https://www.grid.ac/institutes/grid.59734.3c", 
        "type": "Organization"
      }, 
      {
        "affiliation": {
          "id": "https://www.grid.ac/institutes/grid.59734.3c", 
          "name": "ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI", 
          "type": "Organization"
        }, 
        "familyName": "ODIN", 
        "givenName": "JOSEPH", 
        "id": "sg:person.01125076145.84", 
        "type": "Person"
      }, 
      {
        "member": "sg:person.01125076145.84", 
        "roleName": "PI", 
        "type": "Role"
      }
    ], 
    "sameAs": [
      "https://app.dimensions.ai/details/grant/grant.2690338"
    ], 
    "sdDataset": "grants", 
    "sdDatePublished": "2019-03-07T12:08", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com.uberresearch.data.processor/core_data/20181219_192338/projects/base/nih_projects_20.xml.gz", 
    "startDate": "2013-08-15T00:00:00Z", 
    "type": "MonetaryGrant", 
    "url": "http://projectreporter.nih.gov/project_info_description.cfm?aid=9608483"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/grant.2690338'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/grant.2690338'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/grant.2690338'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/grant.2690338'


 

This table displays all metadata directly associated to this object as RDF triples.

107 TRIPLES      19 PREDICATES      84 URIs      76 LITERALS      5 BLANK NODES

Subject Predicate Object
1 sg:grant.2690338 schema:about anzsrc-for:2211
2 schema:amount Ne7fb9bc4392d452a9b0f7b09f63ad46d
3 schema:description The Drug Induced Liver Injury Network (DILIN), sponsored by NIDDK was established in 2003 to identify cases of DILI across a diverse demographic and geographic spectrum. Mount Sinai has been an integral part of the DILIN since 2013 and helped the network increase recruitment such that patient accrual now exceeds expectations. The current 6 clinical sites have performed very well, with Mount Sinai among the leading enrolling sites, particularly for acute DILI cases. The integration of several new hospitals to the Mount Sinai Health System and formation of a Liver Institute to organize hepatology care across the health system will likely result in an increase in enrollment from the Mount Sinai DILIN site with added ethnic diversity. As a whole, the DILIN is well positioned to embark on important goals: continuing to recruit patients early in the course of illness to identify DILI biomarkers; increase the racial/ethnic diversity of patients in the prospective cohort by focused recruitment in urban areas; enrollment of herbal and dietary supplement (HDS) cases along with analysis of HDS products collected in the repository; setting up systems for early detection of drugs or HDS associated with DILI to assist regulatory authorities; and continuing to provide accurate clinical information about DILI through published literature and support for the Livertox website. The Specific Aims for the Mount Sinai site are as follows: 1) To enroll adults and children with DILI in the current DILIN prospective and retrospective databases; 2) To specifically enroll patients early in the course of suspected DILI; 3) To enrich the current DILIN prospective and retrospective databases with patients of non-Caucasian ethnicity; 4) To evaluate serum and genetic biomarkers for chemotherapy-induced liver injury and determine if melatonin pretreatment prevents chemotherapy-induced liver injury; and 5) To rapidly identify newly approved prescription medications and new HDS formulations that cause unexpected concentrations of DILI cases.
4 schema:endDate 2023-06-30T00:00:00Z
5 schema:funder https://www.grid.ac/institutes/grid.419635.c
6 schema:identifier N9080a567dd8c48b1929958c2a79dad28
7 N99d55e038f614d7d8930eb3821d9f065
8 schema:inLanguage en
9 schema:keywords DILI
10 DILI biomarkers
11 DILI cases
12 Drug Induced Liver Injury Network
13 HDS
14 HDS products
15 Liver Institute
16 Livertox website
17 Mount Sinai
18 Mount Sinai DILIN site
19 Mount Sinai Health System
20 Mount Sinai Regional Drug Induced Liver Injury Network Site
21 Mount Sinai site
22 NIDDK
23 Specific Aims
24 accurate clinical information
25 acute DILI cases
26 adults
27 analysis
28 cases
29 chemotherapy
30 children
31 clinical sites
32 course
33 current DILIN
34 dietary supplements
35 drugs
36 early detection
37 enrollment
38 ethnic diversity
39 expectations
40 focused recruitment
41 formation
42 genetic biomarkers
43 geographic spectrum
44 health system
45 hepatology care
46 illness
47 important goal
48 increase
49 integral part
50 integration
51 literature
52 liver injury
53 melatonin pretreatment
54 network
55 new HDS formulations
56 non-Caucasian ethnicity
57 patients
58 prescription medications
59 prospective cohort
60 recruitment
61 regulatory authorities
62 repository
63 retrospective database
64 serum
65 several new hospitals
66 sites
67 support
68 system
69 unexpected concentration
70 urban areas
71 whole
72 schema:name Mount Sinai Regional Drug Induced Liver Injury Network Site
73 schema:recipient N13c40056404043508a84f5c3abeac26e
74 sg:person.01125076145.84
75 https://www.grid.ac/institutes/grid.59734.3c
76 schema:sameAs https://app.dimensions.ai/details/grant/grant.2690338
77 schema:sdDatePublished 2019-03-07T12:08
78 schema:sdLicense https://scigraph.springernature.com/explorer/license/
79 schema:sdPublisher Ne046272494fc4c9eb253a36a72b576c8
80 schema:startDate 2013-08-15T00:00:00Z
81 schema:url http://projectreporter.nih.gov/project_info_description.cfm?aid=9608483
82 sgo:license sg:explorer/license/
83 sgo:sdDataset grants
84 rdf:type schema:MonetaryGrant
85 N13c40056404043508a84f5c3abeac26e schema:member sg:person.01125076145.84
86 schema:roleName PI
87 rdf:type schema:Role
88 N9080a567dd8c48b1929958c2a79dad28 schema:name dimensions_id
89 schema:value 2690338
90 rdf:type schema:PropertyValue
91 N99d55e038f614d7d8930eb3821d9f065 schema:name nih_id
92 schema:value U01DK100928
93 rdf:type schema:PropertyValue
94 Ne046272494fc4c9eb253a36a72b576c8 schema:name Springer Nature - SN SciGraph project
95 rdf:type schema:Organization
96 Ne7fb9bc4392d452a9b0f7b09f63ad46d schema:currency USD
97 schema:value 2005978
98 rdf:type schema:MonetaryAmount
99 anzsrc-for:2211 schema:inDefinedTermSet anzsrc-for:
100 rdf:type schema:DefinedTerm
101 sg:person.01125076145.84 schema:affiliation https://www.grid.ac/institutes/grid.59734.3c
102 schema:familyName ODIN
103 schema:givenName JOSEPH
104 rdf:type schema:Person
105 https://www.grid.ac/institutes/grid.419635.c schema:Organization
106 https://www.grid.ac/institutes/grid.59734.3c schema:name ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
107 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...