Trans-cranial Direct Current Stimulation to Treat Aphasia: Phase II Trial View Homepage


Ontology type: schema:MonetaryGrant     


Grant Info

YEARS

2012-2018

FUNDING AMOUNT

4444131 USD

ABSTRACT

DESCRIPTION (provided by applicant): Stroke is the leading cause of adult disability in the United States. One of the most devastating impairments resulting from stroke is aphasia, a language impairment caused by left hemisphere damage involving cortical language areas. Although considerable research effort has focused on increasing aphasia treatment efficacy, most chronic stroke patients with aphasia experience limited recovery. Therefore, enhanced aphasia treatment outcome is of paramount interest as it may improve patients' communication ability and quality of life. Recent studies utilizing animal models suggest that low current transcranial direct current stimulation (tDCS) can locally increase the secretion of brain derived neurotrophic factor (BDNF), a protein that is crucial for induction of brain plasticity. Research i humans has further demonstrated the positive effect of anodal tDCS (A-tDCS) on learning in normal subjects. For the first time, we have shown in a pair of studies how A-tDCS can significantly enhance the effect of the behavioral treatment of anomia (impaired ability to name common objects) in patients with chronic stroke-induced aphasia. Capitalizing on these findings as well as our other research aimed at understanding brain plasticity associated with aphasia treatment, we propose to conduct a Phase II clinical trial to examine the effect of A-tDCS on anomia treatment outcome in patients with chronic stroke. This project will include a randomized, prospective, double-blind trial with two arms (active vs. control) wherein chronically stable stroke patients will receive behavioral aphasia treatment coupled with either A-tDCS or sham tDCS (S-tDCS). Because anomia is the hallmark impairment in aphasia and is present in all aphasic patients, regardless of severity or aphasia type, the primary outcome factor will be anomia severity, defined as the ability to correctly name common objects. The long-term goal of this research is to conduct a Phase III trial to determine if A-tDCS significantly enhances the effect of behavioral aphasia treatment. If the A-tDCS is proven to have a positive effect on aphasia treatment outcome, it is possible that patients who currently receive limited or no treatment benefit may respond to treatment when it is coupled with A-tDCS. Similarly, it is possible that A-tDCS may further boost the treatment effect for patients who respond positively to treatment in the absence of direct brain stimulation. More... »

URL

http://projectreporter.nih.gov/project_info_description.cfm?aid=9033892

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/2211", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/2211", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }
    ], 
    "amount": {
      "currency": "USD", 
      "type": "MonetaryAmount", 
      "value": "4444131"
    }, 
    "description": "DESCRIPTION (provided by applicant): Stroke is the leading cause of adult disability in the United States. One of the most devastating impairments resulting from stroke is aphasia, a language impairment caused by left hemisphere damage involving cortical language areas. Although considerable research effort has focused on increasing aphasia treatment efficacy, most chronic stroke patients with aphasia experience limited recovery. Therefore, enhanced aphasia treatment outcome is of paramount interest as it may improve patients' communication ability and quality of life. Recent studies utilizing animal models suggest that low current transcranial direct current stimulation (tDCS) can locally increase the secretion of brain derived neurotrophic factor (BDNF), a protein that is crucial for induction of brain plasticity. Research i humans has further demonstrated the positive effect of anodal tDCS (A-tDCS) on learning in normal subjects. For the first time, we have shown in a pair of studies how A-tDCS can significantly enhance the effect of the behavioral treatment of anomia (impaired ability to name common objects) in patients with chronic stroke-induced aphasia. Capitalizing on these findings as well as our other research aimed at understanding brain plasticity associated with aphasia treatment, we propose to conduct a Phase II clinical trial to examine the effect of A-tDCS on anomia treatment outcome in patients with chronic stroke. This project will include a randomized, prospective, double-blind trial with two arms (active vs. control) wherein chronically stable stroke patients will receive behavioral aphasia treatment coupled with either A-tDCS or sham tDCS (S-tDCS). Because anomia is the hallmark impairment in aphasia and is present in all aphasic patients, regardless of severity or aphasia type, the primary outcome factor will be anomia severity, defined as the ability to correctly name common objects. The long-term goal of this research is to conduct a Phase III trial to determine if A-tDCS significantly enhances the effect of behavioral aphasia treatment. If the A-tDCS is proven to have a positive effect on aphasia treatment outcome, it is possible that patients who currently receive limited or no treatment benefit may respond to treatment when it is coupled with A-tDCS. Similarly, it is possible that A-tDCS may further boost the treatment effect for patients who respond positively to treatment in the absence of direct brain stimulation.", 
    "endDate": "2018-03-31T00:00:00Z", 
    "funder": {
      "id": "https://www.grid.ac/institutes/grid.214431.1", 
      "type": "Organization"
    }, 
    "id": "sg:grant.2689542", 
    "identifier": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "2689542"
        ]
      }, 
      {
        "name": "nih_id", 
        "type": "PropertyValue", 
        "value": [
          "U01DC011739"
        ]
      }
    ], 
    "inLanguage": [
      "en"
    ], 
    "keywords": [
      "Research i humans", 
      "aphasic patients", 
      "treatment effects", 
      "phase II trial", 
      "long-term goal", 
      "positive effect", 
      "phase II clinical trials", 
      "Trans-cranial Direct Current Stimulation", 
      "enhanced aphasia treatment outcome", 
      "project", 
      "findings", 
      "language impairment", 
      "secretion", 
      "applicants", 
      "United States", 
      "stable stroke patients", 
      "effect", 
      "patients' communication abilities", 
      "description", 
      "aphasia", 
      "Recent studies", 
      "induction", 
      "brain", 
      "ability", 
      "cause", 
      "aphasia treatment outcomes", 
      "anomia", 
      "sham tDCS", 
      "anomia severity", 
      "treatment benefit", 
      "patients", 
      "adult disability", 
      "derived neurotrophic factor", 
      "life", 
      "behavioral treatment", 
      "arm", 
      "double-blind trial", 
      "common objects", 
      "Treat Aphasia", 
      "primary outcome factors", 
      "BDNF", 
      "severity", 
      "pairs", 
      "aphasia treatment efficacy", 
      "direct current stimulation", 
      "research", 
      "aphasia treatment", 
      "considerable research effort", 
      "cortical language areas", 
      "most chronic stroke patients", 
      "protein", 
      "absence", 
      "tDCS", 
      "behavioral aphasia treatment", 
      "phase III trials", 
      "control", 
      "low current transcranial", 
      "first time", 
      "paramount interest", 
      "hallmark impairment", 
      "animal models", 
      "limited recovery", 
      "chronic stroke", 
      "aphasia experience", 
      "quality", 
      "left hemisphere damage", 
      "direct brain stimulation", 
      "brain plasticity", 
      "devastating impairments", 
      "treatment", 
      "anodal tDCS", 
      "stroke", 
      "anomia treatment outcome", 
      "study", 
      "normal subjects", 
      "aphasia type", 
      "other research"
    ], 
    "name": "Trans-cranial Direct Current Stimulation to Treat Aphasia: Phase II Trial", 
    "recipient": [
      {
        "id": "https://www.grid.ac/institutes/grid.254567.7", 
        "type": "Organization"
      }, 
      {
        "affiliation": {
          "id": "https://www.grid.ac/institutes/grid.254567.7", 
          "name": "UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA", 
          "type": "Organization"
        }, 
        "familyName": "FRIDRIKSSON", 
        "givenName": "JULIUS", 
        "id": "sg:person.01305543251.08", 
        "type": "Person"
      }, 
      {
        "member": "sg:person.01305543251.08", 
        "roleName": "PI", 
        "type": "Role"
      }
    ], 
    "sameAs": [
      "https://app.dimensions.ai/details/grant/grant.2689542"
    ], 
    "sdDataset": "grants", 
    "sdDatePublished": "2019-03-07T12:08", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com.uberresearch.data.processor/core_data/20181219_192338/projects/base/nih_projects_20.xml.gz", 
    "startDate": "2012-04-03T00:00:00Z", 
    "type": "MonetaryGrant", 
    "url": "http://projectreporter.nih.gov/project_info_description.cfm?aid=9033892"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/grant.2689542'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/grant.2689542'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/grant.2689542'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/grant.2689542'


 

This table displays all metadata directly associated to this object as RDF triples.

121 TRIPLES      19 PREDICATES      99 URIs      91 LITERALS      5 BLANK NODES

Subject Predicate Object
1 sg:grant.2689542 schema:about anzsrc-for:2211
2 schema:amount N6644e40b0e1747ab9a0b38caf312d112
3 schema:description DESCRIPTION (provided by applicant): Stroke is the leading cause of adult disability in the United States. One of the most devastating impairments resulting from stroke is aphasia, a language impairment caused by left hemisphere damage involving cortical language areas. Although considerable research effort has focused on increasing aphasia treatment efficacy, most chronic stroke patients with aphasia experience limited recovery. Therefore, enhanced aphasia treatment outcome is of paramount interest as it may improve patients' communication ability and quality of life. Recent studies utilizing animal models suggest that low current transcranial direct current stimulation (tDCS) can locally increase the secretion of brain derived neurotrophic factor (BDNF), a protein that is crucial for induction of brain plasticity. Research i humans has further demonstrated the positive effect of anodal tDCS (A-tDCS) on learning in normal subjects. For the first time, we have shown in a pair of studies how A-tDCS can significantly enhance the effect of the behavioral treatment of anomia (impaired ability to name common objects) in patients with chronic stroke-induced aphasia. Capitalizing on these findings as well as our other research aimed at understanding brain plasticity associated with aphasia treatment, we propose to conduct a Phase II clinical trial to examine the effect of A-tDCS on anomia treatment outcome in patients with chronic stroke. This project will include a randomized, prospective, double-blind trial with two arms (active vs. control) wherein chronically stable stroke patients will receive behavioral aphasia treatment coupled with either A-tDCS or sham tDCS (S-tDCS). Because anomia is the hallmark impairment in aphasia and is present in all aphasic patients, regardless of severity or aphasia type, the primary outcome factor will be anomia severity, defined as the ability to correctly name common objects. The long-term goal of this research is to conduct a Phase III trial to determine if A-tDCS significantly enhances the effect of behavioral aphasia treatment. If the A-tDCS is proven to have a positive effect on aphasia treatment outcome, it is possible that patients who currently receive limited or no treatment benefit may respond to treatment when it is coupled with A-tDCS. Similarly, it is possible that A-tDCS may further boost the treatment effect for patients who respond positively to treatment in the absence of direct brain stimulation.
4 schema:endDate 2018-03-31T00:00:00Z
5 schema:funder https://www.grid.ac/institutes/grid.214431.1
6 schema:identifier N1c2b065016c34761a5de0f41d7aab172
7 N56eaaba24c8e42ed812c982682040963
8 schema:inLanguage en
9 schema:keywords BDNF
10 Recent studies
11 Research i humans
12 Trans-cranial Direct Current Stimulation
13 Treat Aphasia
14 United States
15 ability
16 absence
17 adult disability
18 animal models
19 anodal tDCS
20 anomia
21 anomia severity
22 anomia treatment outcome
23 aphasia
24 aphasia experience
25 aphasia treatment
26 aphasia treatment efficacy
27 aphasia treatment outcomes
28 aphasia type
29 aphasic patients
30 applicants
31 arm
32 behavioral aphasia treatment
33 behavioral treatment
34 brain
35 brain plasticity
36 cause
37 chronic stroke
38 common objects
39 considerable research effort
40 control
41 cortical language areas
42 derived neurotrophic factor
43 description
44 devastating impairments
45 direct brain stimulation
46 direct current stimulation
47 double-blind trial
48 effect
49 enhanced aphasia treatment outcome
50 findings
51 first time
52 hallmark impairment
53 induction
54 language impairment
55 left hemisphere damage
56 life
57 limited recovery
58 long-term goal
59 low current transcranial
60 most chronic stroke patients
61 normal subjects
62 other research
63 pairs
64 paramount interest
65 patients
66 patients' communication abilities
67 phase II clinical trials
68 phase II trial
69 phase III trials
70 positive effect
71 primary outcome factors
72 project
73 protein
74 quality
75 research
76 secretion
77 severity
78 sham tDCS
79 stable stroke patients
80 stroke
81 study
82 tDCS
83 treatment
84 treatment benefit
85 treatment effects
86 schema:name Trans-cranial Direct Current Stimulation to Treat Aphasia: Phase II Trial
87 schema:recipient N3b712fc189f641ae994d3d69625f2f7e
88 sg:person.01305543251.08
89 https://www.grid.ac/institutes/grid.254567.7
90 schema:sameAs https://app.dimensions.ai/details/grant/grant.2689542
91 schema:sdDatePublished 2019-03-07T12:08
92 schema:sdLicense https://scigraph.springernature.com/explorer/license/
93 schema:sdPublisher N163f184014a142889802e8b04f39802a
94 schema:startDate 2012-04-03T00:00:00Z
95 schema:url http://projectreporter.nih.gov/project_info_description.cfm?aid=9033892
96 sgo:license sg:explorer/license/
97 sgo:sdDataset grants
98 rdf:type schema:MonetaryGrant
99 N163f184014a142889802e8b04f39802a schema:name Springer Nature - SN SciGraph project
100 rdf:type schema:Organization
101 N1c2b065016c34761a5de0f41d7aab172 schema:name nih_id
102 schema:value U01DC011739
103 rdf:type schema:PropertyValue
104 N3b712fc189f641ae994d3d69625f2f7e schema:member sg:person.01305543251.08
105 schema:roleName PI
106 rdf:type schema:Role
107 N56eaaba24c8e42ed812c982682040963 schema:name dimensions_id
108 schema:value 2689542
109 rdf:type schema:PropertyValue
110 N6644e40b0e1747ab9a0b38caf312d112 schema:currency USD
111 schema:value 4444131
112 rdf:type schema:MonetaryAmount
113 anzsrc-for:2211 schema:inDefinedTermSet anzsrc-for:
114 rdf:type schema:DefinedTerm
115 sg:person.01305543251.08 schema:affiliation https://www.grid.ac/institutes/grid.254567.7
116 schema:familyName FRIDRIKSSON
117 schema:givenName JULIUS
118 rdf:type schema:Person
119 https://www.grid.ac/institutes/grid.214431.1 schema:Organization
120 https://www.grid.ac/institutes/grid.254567.7 schema:name UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
121 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...