Multicenter AIDS Cohort Study View Homepage


Ontology type: schema:MonetaryGrant     


Grant Info

YEARS

1993-2019

FUNDING AMOUNT

66383235 USD

ABSTRACT

DESCRIPTION (provided by applicant): The Northwestern University (NU) Clinical Research Site (CRS) for the Multicenter AIDS Cohort Study (MACS) addresses the highest research priorities in AIDS research through retention and maintenance of the cohort, collection and repository storage of specimens, and development and implementation of the MACS Research Agenda. Through the leadership we provide and the data and biological specimens we collect, the NU CRS actively contributes to all MACS core protocols and thematic substudies to characterize the long-term, natural and treated history of HIV infection in a cohort of men who report sex with men (MSM). We strictly adhere to good practice guidelines, established policies and procedures, and robust quality assurance and quality control measures to ensure the accuracy, reproducibility, and integrity of the clinical and laboratory data and biological specimens. Scientific and administrative management provides both the flexibility and means to conduct multidisciplinary research projects as well as the resources to respond rapidly to evolving scientific opportunities. For the past 30 years, we have maintained a strong AIDS research portfolio that supports basic discovery research into important priority areas in etiology and pathogenesis, behavior and social science, and natural history and epidemiology. The diversity of the work makes possible a broad and multidisciplinary view of AIDS research. Scientific questions take full advantage of the strengths of the MACS, namely, its duration and the continuity of data and specimens that timespan provides. Researchers can distinguish data and specimens from men before and after infection, before and after beginning medications, or before and after the development of comorbidities or their complications. Productive relationships across the entire MACS consortium, as well as other consortia and organizations, have coalesced around specific issues to advance scientific knowledge, the health of people, and policy development. By capitalizing on the unique resources of the NU Genome Sequencing and Analysis Program, we are able to explore the human genome and define the biological circuits that underlie cellular processes in search of the molecular basis of disease. MACS genomic data are shared among investigators in an interpretable manner and made widely available to the research community through a controlled-access system that reduces the risks of sharing potentially identifying data. Looking ahead, the NU CRS will continue to support a rational, holistic research plan that will provide insight into the evolving biological and psychosocial characteristics of the HIV/AIDS epidemic in MSM. We will build upon our AIDS research portfolio built on a unique cohort, rich with clinical and biological information. We will replace existing cohort members who die or are lost to follow-up using a rolling cohort design. With data obtained through multidisciplinary studies of high scientific quality, we expect to advance research that will help to better manage the care and treatment of people living with HIV/AIDS, and contribute to vaccine development as well as public health policy and interventions. More... »

URL

http://projectreporter.nih.gov/project_info_description.cfm?aid=9480838

Related SciGraph Publications

  • 2019-12. Kidney disease risk factors associate with urine biomarkers concentrations in HIV-positive persons; a cross-sectional study in BMC NEPHROLOGY
  • 2018-12. Measuring associations between the microbiota and repeated measures of continuous clinical variables using a lasso-penalized generalized linear mixed model in BIODATA MINING
  • 2018-12. Human immunodeficiency virus type 1 (HIV-1)-mediated neuroinflammation dysregulates neurogranin and induces synaptodendritic injury in JOURNAL OF NEUROINFLAMMATION
  • 2018-11. Low T-cell subsets prior to development of virus-associated cancer in HIV-seronegative men who have sex with men in CANCER CAUSES & CONTROL
  • 2018-05. Association Between Depressive Symptom Patterns and Clinical Profiles Among Persons Living with HIV in AIDS AND BEHAVIOR
  • 2017-12. Fine-mapping of genetic loci driving spontaneous clearance of hepatitis C virus infection in SCIENTIFIC REPORTS
  • 2017-12. Effect of prolonged freezing of semen on exosome recovery and biologic activity in SCIENTIFIC REPORTS
  • 2017-10. Unsafe Sexual Behavior Among Gay/Bisexual Men in the Era of Combination Antiretroviral Therapy (cART) in AIDS AND BEHAVIOR
  • 2017-08. Association of long-term patterns of depressive symptoms and attention/executive function among older men with and without human immunodeficiency virus in JOURNAL OF NEUROVIROLOGY
  • 2017-07. Racial differences in prostate cancer risk in young HIV-positive and HIV-negative men: a prospective cohort study in CANCER CAUSES & CONTROL
  • 2017-07. Longitudinal Modeling of Depressive Trajectories Among HIV-Infected Men Using Cocaine in AIDS AND BEHAVIOR
  • 2017-06. Visceral fat is associated with brain structure independent of human immunodeficiency virus infection status in JOURNAL OF NEUROVIROLOGY
  • 2017-05. Stability of Bisexual Behavior and Extent of Viral Bridging Behavior Among Men Who Have Sex with Men and Women in ARCHIVES OF SEXUAL BEHAVIOR
  • 2017-04. Association of midlife smoking status with change in processing speed and mental flexibility among HIV-seropositive and HIV-seronegative older men: the Multicenter AIDS Cohort Study in JOURNAL OF NEUROVIROLOGY
  • 2017-04. Trajectories of Marijuana Use among HIV-seropositive and HIV-seronegative MSM in the Multicenter AIDS Cohort Study (MACS), 1984–2013 in AIDS AND BEHAVIOR
  • 2016-12. Identification of the transcripts associated with spontaneous HCV clearance in individuals co-infected with HIV and HCV in BMC INFECTIOUS DISEASES
  • 2016-12. Correlation of the lung microbiota with metabolic profiles in bronchoalveolar lavage fluid in HIV infection in MICROBIOME
  • 2016-12. The association of medication use with clearance or persistence of oral HPV infection in CANCER CAUSES & CONTROL
  • 2016-10. Targeted Spontaneous Reporting: Assessing Opportunities to Conduct Routine Pharmacovigilance for Antiretroviral Treatment on an International Scale in DRUG SAFETY
  • 2016-09. Cortical brain atrophy and intra-individual variability in neuropsychological test performance in HIV disease in BRAIN IMAGING AND BEHAVIOR
  • 2016-08-11. Identification of Siglec-1 null individuals infected with HIV-1 in NATURE COMMUNICATIONS
  • 2016-08. Long-Term Cigarette Smoking Trajectories Among HIV-Seropositive and Seronegative MSM in the Multicenter AIDS Cohort Study in AIDS AND BEHAVIOR
  • 2016-05. Enrichment of the lung microbiome with oral taxa is associated with lung inflammation of a Th17 phenotype in NATURE MICROBIOLOGY
  • 2016-03. Trends and Predictors of Cigarette Smoking Among HIV Seropositive and Seronegative Men: The Multicenter Aids Cohort Study in AIDS AND BEHAVIOR
  • 2015-12. Lipid levels in HIV-positive men receiving anti-retroviral therapy are not associated with copy number variation of reverse cholesterol transport pathway genes in BMC RESEARCH NOTES
  • 2015-04. Level of Adherence and HIV RNA Suppression in the Current Era of Highly Active Antiretroviral Therapy (HAART) in AIDS AND BEHAVIOR
  • 2015-02. No association between Apoε4 alleles, HIV infection, age, neuropsychological outcome, or death in JOURNAL OF NEUROVIROLOGY
  • 2015-02. Depression and Sexual Dysfunction Among HIV-Positive and HIV-Negative Men Who Have Sex With Men: Mediation by Use of Antidepressants and Recreational Stimulants in ARCHIVES OF SEXUAL BEHAVIOR
  • 2014-12. Pulmonary symptoms and diagnoses are associated with HIV in the MACS and WIHS cohorts in BMC PULMONARY MEDICINE
  • 2014-12. Morning free and total testosterone in HIV-infected men: implications for the assessment of hypogonadism in AIDS RESEARCH AND THERAPY
  • 2014-09. SNP screening of central MHC-identified HLA-DMB as a candidate susceptibility gene for HIV-related Kaposi’s sarcoma in GENES & IMMUNITY
  • 2014-06. The longitudinal and interactive effects of HIV status, stimulant use, and host genotype upon neurocognitive functioning in JOURNAL OF NEUROVIROLOGY
  • 2014-05. Risk Factors for Fatty Liver in the Multicenter AIDS Cohort Study in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2013-07. Structure of tumor necrosis factor-alpha haploblocks in European populations in IMMUNOGENETICS
  • 2013-05. It Gets Better: Resolution of Internalized Homophobia Over Time and Associations with Positive Health Outcomes Among MSM in AIDS AND BEHAVIOR
  • 2013-03. The interaction between smoking status and highly active antiretroviral therapy (HAART) use on the risk of Kaposi’s sarcoma (KS) in a cohort of HIV-infected men in BRITISH JOURNAL OF CANCER
  • 2013-02. Neuropsychological test performance before and after HIV-1 seroconversion: the Multicenter AIDS Cohort Study in JOURNAL OF NEUROVIROLOGY
  • 2013. Quantiles of Residual Survival in RISK ASSESSMENT AND EVALUATION OF PREDICTIONS
  • 2012-11. Labor Force Participation and Health-Related Quality of Life in HIV-Positive Men Who Have Sex with Men: The Multicenter AIDS Cohort Study in AIDS AND BEHAVIOR
  • 2012-08. Application of Syndemic Theory to Black Men Who Have Sex with Men in the Multicenter AIDS Cohort Study in JOURNAL OF URBAN HEALTH
  • 2012-04. Middle-Aged and Older Men Who Have Sex With Men Exhibit Multiple Trajectories With Respect to the Number of Sexual Partners in AIDS AND BEHAVIOR
  • 2012-04. Sexual, Behavioral, and Quality of Life Characteristics of Healthy Weight, Overweight, and Obese Gay and Bisexual Men: Findings from a Prospective Cohort Study in ARCHIVES OF SEXUAL BEHAVIOR
  • 2012-02. Factors affecting brain structure in men with HIV disease in the post-HAART era in NEURORADIOLOGY
  • 2011-10. Platelet decline as a predictor of brain injury in HIV infection in JOURNAL OF NEUROVIROLOGY
  • 2011-08. Universal GFR determination based on two time points during plasma iohexol disappearance in KIDNEY INTERNATIONAL
  • 2011-06. Subcortical brain atrophy persists even in HAART-regulated HIV disease in BRAIN IMAGING AND BEHAVIOR
  • 2011-04. Differential microRNA regulation of HLA-C expression and its association with HIV control in NATURE
  • 2010-12. CD4 count at presentation for HIV care in the United States and Canada: Are those over 50 years more likely to have a delayed presentation? in AIDS RESEARCH AND THERAPY
  • 2010-09. Longitudinal psychomotor speed performance in human immunodeficiency virus-seropositive individuals: impact of age and serostatus in JOURNAL OF NEUROVIROLOGY
  • 2010-04. A copula model for bivariate hybrid censored survival data with application to the MACS study in LIFETIME DATA ANALYSIS
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