Predoctoral Training in Signaling and Cellular Regulation View Homepage


Ontology type: schema:MonetaryGrant     


Grant Info

YEARS

2000-2021

FUNDING AMOUNT

5910792.0 USD

ABSTRACT

? DESCRIPTION (provided by applicant): The goal of this training grant proposal is to prepare predoctoral trainees for productive research careers in the field of signaling and cellular regulation. The training faculty consists of an outstanding, internationally recognized group of investigators in the Department of Chemistry and Biochemistry and the Department of Molecular, Cellular and Developmental Biology, who study basic cell regulatory mechanisms through discovery and characterization of key components in signaling pathways, transfer of biological information through protein conformational changes and posttranslational modifications, computational analysis and mathematical modeling of complex biological pathways, and formulation of new therapeutic strategies for human diseases. The program provides students with rigorous training in experimental design, scientific technique, and data evaluation, exposure to a wide range of scientific disciplines, training in classroom teaching, opportunities for scientific presentation, and training in standards for professional conduct. In Year 1, students take coursework and teaching duties in their home departments, and carry out laboratory rotations. At the end of Year 1, students choose a thesis advisor and elect to join this training program. In Year 2, students begin research and take elective coursework tailored to this program. Written and oral cumulative exams including the defense of a dissertation research proposal are required to advance to Ph.D. candidacy. In Years 3 and beyond, students obtain high caliber research training through the thesis project, with progress monitored yearly until graduation. Students add to their breadth and knowledge by participating in program symposia, supergroups, journal clubs, and seminars, and by presenting their work before large audiences. Students complete the program by defending a doctoral dissertation and receive a Ph.D. degree in Biochemistry or MCDB. Most students finish within 6 years of matriculation, and go on to postdoctoral training and careers in academia, research institutes, or pharmaceutical/biotechnology companies. More... »

URL

http://projectreporter.nih.gov/project_info_description.cfm?aid=9959417

Related SciGraph Publications

  • 2021-06-02. Transcription factor enrichment analysis (TFEA) quantifies the activity of multiple transcription factors from a single experiment in COMMUNICATIONS BIOLOGY
  • 2021-04-26. Positive natural selection in primate genes of the type I interferon response in NONE
  • 2021-02-02. Histone Parylation factor 1 contributes to the inhibition of PARP1 by cancer drugs in NATURE COMMUNICATIONS
  • 2020-09-30. Single molecule studies reveal that p53 tetramers dynamically bind response elements containing one or two half sites in SCIENTIFIC REPORTS
  • 2019-08-07. Pol II phosphorylation regulates a switch between transcriptional and splicing condensates in NATURE
  • 2019-06-28. Intracellular Zn2+ transients modulate global gene expression in dissociated rat hippocampal neurons in SCIENTIFIC REPORTS
  • 2019-03-05. The ancient sarcomeric myosins found in specialized muscles in SKELETAL MUSCLE
  • 2017-01-16. Recurrent RNA motifs as scaffolds for genetically encodable small molecule biosensors in NATURE CHEMICAL BIOLOGY
  • 2016-10-31. Multiple dynamin family members collaborate to drive mitochondrial division in NATURE
  • 2016-07-07. Mps1 kinase regulates tumor cell viability via its novel role in mitochondria in CELL DEATH & DISEASE
  • 2015-12-02. Structure and function of ER membrane contact sites with other organelles in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2015-11-10. A novel two-step genome editing strategy with CRISPR-Cas9 provides new insights into telomerase action and TERT gene expression in GENOME BIOLOGY
  • 2015-10-07. Mediating transcription and RNA export in NATURE
  • 2015-09-28. Mediator Kinase Inhibition Further Activates Super-Enhancer Associated Genes in AML in NATURE
  • 2015-09-24. Longitudinal tracking of single live cancer cells to understand cell cycle effects of the nuclear export inhibitor, selinexor in SCIENTIFIC REPORTS
  • 2015-05-27. Centrin-2 (Cetn2) mediated regulation of FGF/FGFR gene expression in Xenopus in SCIENTIFIC REPORTS
  • 2015-02-18. The Mediator complex: a central integrator of transcription in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2014-12-05. A chemical genetic approach to probe the function of PINK1 in regulating mitochondrial dynamics in CELL RESEARCH
  • 2013-08-25. Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences in NATURE BIOTECHNOLOGY
  • 2013-08-25. MicroRNA-205 Controls Neonatal Expansion of Skin Stem Cells by Modulating the PI3K Pathway in NATURE CELL BIOLOGY
  • 2013-02-05. From molecules to dynamic biological communities in BIOLOGY & PHILOSOPHY
  • 2012-12-13. Global biogeography of highly diverse protistan communities in soil in THE ISME JOURNAL: MULTIDISCIPLINARY JOURNAL OF MICROBIAL ECOLOGY
  • 2012-10-25. Collaborative cloud-enabled tools allow rapid, reproducible biological insights in THE ISME JOURNAL: MULTIDISCIPLINARY JOURNAL OF MICROBIAL ECOLOGY
  • 2012-10-09. A role for RNA post-transcriptional regulation in satellite cell activation in SKELETAL MUSCLE
  • 2012-07-02. Oncogenic B-Raf signaling in melanoma cells controls a network of microRNAs with combinatorial functions in ONCOGENE
  • 2012-03-08. Ultra-high-throughput microbial community analysis on the Illumina HiSeq and MiSeq platforms in THE ISME JOURNAL: MULTIDISCIPLINARY JOURNAL OF MICROBIAL ECOLOGY
  • 2011-12-28. Partners in crime: the TGFβ and MAPK pathways in cancer progression in CELL & BIOSCIENCE
  • 2011-12-16. Experimental and analytical tools for studying the human microbiome in NATURE REVIEWS GENETICS
  • 2011-12-01. Comparative metagenomic, phylogenetic and physiological analyses of soil microbial communities across nitrogen gradients in THE ISME JOURNAL: MULTIDISCIPLINARY JOURNAL OF MICROBIAL ECOLOGY
  • 2011-07-17. Bayesian community-wide culture-independent microbial source tracking in NATURE METHODS
  • 2011-06-30. Impact of training sets on classification of high-throughput bacterial 16s rRNA gene surveys in THE ISME JOURNAL: MULTIDISCIPLINARY JOURNAL OF MICROBIAL ECOLOGY
  • 2010-11-18. Examining the global distribution of dominant archaeal populations in soil in THE ISME JOURNAL: MULTIDISCIPLINARY JOURNAL OF MICROBIAL ECOLOGY
  • 2010-08-08. MICU1 encodes a mitochondrial EF hand protein required for Ca2+ uptake in NATURE
  • 2010-06-06. C. elegans transthyretin-like protein TTR-52 mediates recognition of apoptotic cells by the CED-1 phagocyte receptor in NATURE CELL BIOLOGY
  • 2010-05-05. Direct sequencing of the human microbiome readily reveals community differences in GENOME BIOLOGY
  • 2010-04-11. QIIME allows analysis of high-throughput community sequencing data in NATURE METHODS
  • 2009-07-03. C. elegans caspase homolog CSP-2 inhibits CED-3 autoactivation and apoptosis in germ cells in CELL DEATH & DIFFERENTIATION
  • 2009-06-01. Plexin B1 is repressed by oncogenic B-Raf signaling and functions as a tumor suppressor in melanoma cells in ONCOGENE
  • 2008-10. Worlds within worlds: evolution of the vertebrate gut microbiota in NATURE REVIEWS MICROBIOLOGY
  • 2008-09-07. Inhibition of CED-3 zymogen activation and apoptosis in Caenorhabditis elegans by caspase homolog CSP-3 in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2008-01-20. Structure of the SAM-II riboswitch bound to S-adenosylmethionine in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2007-08-21. PyCogent: a toolkit for making sense from sequence in GENOME BIOLOGY
  • 2006-10-25. Unraveling transcriptional control and cis-regulatory codes using the software suite GeneACT in GENOME BIOLOGY
  • 2006-08-07. UniFrac – An online tool for comparing microbial community diversity in a phylogenetic context in BMC BIOINFORMATICS
  • 2006-02. Protein-protein interaction assays: eliminating false positive interactions in NATURE METHODS
  • 2005-10-18. Riboswitches: natural SELEXion in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2004-11. Structure of a natural guanine-responsive riboswitch complexed with the metabolite hypoxanthine in NATURE
  • 2004-08-08. B2 RNA binds directly to RNA polymerase II to repress transcript synthesis in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2003-08-31. Structure of NFAT1 bound as a dimer to the HIV-1 LTR κB element in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "type": "DefinedTerm"
          }
        ], 
        "amount": {
          "currency": "USD", 
          "type": "MonetaryAmount", 
          "value": 5910792.0
        }, 
        "description": "? DESCRIPTION (provided by applicant): The goal of this training grant proposal is to prepare predoctoral trainees for productive research careers in the field of signaling and cellular regulation. The training faculty consists of an outstanding, internationally recognized group of investigators in the Department of Chemistry and Biochemistry and the Department of Molecular, Cellular and Developmental Biology, who study basic cell regulatory mechanisms through discovery and characterization of key components in signaling pathways, transfer of biological information through protein conformational changes and posttranslational modifications, computational analysis and mathematical modeling of complex biological pathways, and formulation of new therapeutic strategies for human diseases. The program provides students with rigorous training in experimental design, scientific technique, and data evaluation, exposure to a wide range of scientific disciplines, training in classroom teaching, opportunities for scientific presentation, and training in standards for professional conduct. In Year 1, students take coursework and teaching duties in their home departments, and carry out laboratory rotations. At the end of Year 1, students choose a thesis advisor and elect to join this training program. In Year 2, students begin research and take elective coursework tailored to this program. Written and oral cumulative exams including the defense of a dissertation research proposal are required to advance to Ph.D. candidacy. In Years 3 and beyond, students obtain high caliber research training through the thesis project, with progress monitored yearly until graduation. Students add to their breadth and knowledge by participating in program symposia, supergroups, journal clubs, and seminars, and by presenting their work before large audiences. Students complete the program by defending a doctoral dissertation and receive a Ph.D. degree in Biochemistry or MCDB. Most students finish within 6 years of matriculation, and go on to postdoctoral training and careers in academia, research institutes, or pharmaceutical/biotechnology companies.", 
        "endDate": "2021-06-30", 
        "funder": {
          "id": "http://www.grid.ac/institutes/grid.280785.0", 
          "type": "Organization"
        }, 
        "id": "sg:grant.2684042", 
        "identifier": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "grant.2684042"
            ]
          }, 
          {
            "name": "nih_id", 
            "type": "PropertyValue", 
            "value": [
              "T32GM008759"
            ]
          }
        ], 
        "inLanguage": [
          "en"
        ], 
        "keywords": [
          "cellular regulation", 
          "protein conformational changes", 
          "complex biological pathways", 
          "cell regulatory mechanisms", 
          "developmental biology", 
          "posttranslational modifications", 
          "regulatory mechanisms", 
          "biological pathways", 
          "biological information", 
          "conformational changes", 
          "human diseases", 
          "new therapeutic strategies", 
          "computational analysis", 
          "regulation", 
          "years of matriculation", 
          "pathway", 
          "biochemistry", 
          "year 1", 
          "classroom teaching", 
          "training faculty", 
          "therapeutic strategies", 
          "teaching duties", 
          "most students", 
          "cumulative exam", 
          "elective coursework", 
          "laboratory rotation", 
          "students", 
          "thesis project", 
          "Department of Molecular", 
          "key component", 
          "signaling", 
          "biology", 
          "Department of Chemistry", 
          "research training", 
          "journal club", 
          "biotechnology companies", 
          "research career", 
          "year 3", 
          "predoctoral training", 
          "thesis advisor", 
          "training program", 
          "pharmaceutical/biotechnology companies", 
          "postdoctoral training", 
          "professional conduct", 
          "Ph.D. degree", 
          "coursework", 
          "year 2", 
          "training", 
          "doctoral dissertation", 
          "rigorous training", 
          "defense", 
          "research proposals", 
          "cellular", 
          "career", 
          "MCDB", 
          "program", 
          "molecular", 
          "discovery", 
          "grant proposals", 
          "wide range", 
          "large audience", 
          "scientific presentations", 
          "Home Department", 
          "scientific disciplines", 
          "mechanism", 
          "teaching", 
          "matriculation", 
          "graduation", 
          "experimental design", 
          "faculty", 
          "characterization", 
          "modification", 
          "seminars", 
          "breadth", 
          "Department", 
          "scientific techniques", 
          "exam", 
          "trainees", 
          "disciplines", 
          "advisors", 
          "dissertation", 
          "groups of investigators", 
          "Supergroup", 
          "opportunities", 
          "academia", 
          "components", 
          "knowledge", 
          "project", 
          "clubs", 
          "proposal", 
          "Research Institute", 
          "changes", 
          "mathematical modeling", 
          "exposure", 
          "progress", 
          "analysis", 
          "research", 
          "disease", 
          "goal", 
          "audience", 
          "duty", 
          "Institute", 
          "transfer", 
          "strategies", 
          "conduct", 
          "standards", 
          "end", 
          "range", 
          "description", 
          "information", 
          "chemistry", 
          "design", 
          "symposium", 
          "degree", 
          "group", 
          "presentation", 
          "work", 
          "evaluation", 
          "investigators", 
          "years", 
          "candidacy", 
          "field", 
          "data evaluation", 
          "modeling", 
          "technique", 
          "rotation", 
          "companies", 
          "elect", 
          "formulation", 
          "predoctoral trainees", 
          "productive research career"
        ], 
        "name": "Predoctoral Training in Signaling and Cellular Regulation", 
        "recipient": [
          {
            "id": "http://www.grid.ac/institutes/grid.266190.a", 
            "type": "Organization"
          }, 
          {
            "affiliation": {
              "id": "http://www.grid.ac/institutes/None", 
              "name": "UNIVERSITY OF COLORADO", 
              "type": "Organization"
            }, 
            "familyName": "AHN", 
            "givenName": "NATALIE G", 
            "id": "sg:person.0577516710.65", 
            "type": "Person"
          }, 
          {
            "member": "sg:person.0577516710.65", 
            "roleName": "PI", 
            "type": "Role"
          }
        ], 
        "sameAs": [
          "https://app.dimensions.ai/details/grant/grant.2684042"
        ], 
        "sdDataset": "grants", 
        "sdDatePublished": "2022-01-01T19:29", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/grant/grant_16.jsonl", 
        "startDate": "2000-07-01", 
        "type": "MonetaryGrant", 
        "url": "http://projectreporter.nih.gov/project_info_description.cfm?aid=9959417"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/grant.2684042'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/grant.2684042'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/grant.2684042'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/grant.2684042'


     

    This table displays all metadata directly associated to this object as RDF triples.

    176 TRIPLES      19 PREDICATES      153 URIs      145 LITERALS      5 BLANK NODES

    Subject Predicate Object
    1 sg:grant.2684042 schema:about anzsrc-for:06
    2 schema:amount Nf9d9f87e698d43a6ad428b867be4e493
    3 schema:description ? DESCRIPTION (provided by applicant): The goal of this training grant proposal is to prepare predoctoral trainees for productive research careers in the field of signaling and cellular regulation. The training faculty consists of an outstanding, internationally recognized group of investigators in the Department of Chemistry and Biochemistry and the Department of Molecular, Cellular and Developmental Biology, who study basic cell regulatory mechanisms through discovery and characterization of key components in signaling pathways, transfer of biological information through protein conformational changes and posttranslational modifications, computational analysis and mathematical modeling of complex biological pathways, and formulation of new therapeutic strategies for human diseases. The program provides students with rigorous training in experimental design, scientific technique, and data evaluation, exposure to a wide range of scientific disciplines, training in classroom teaching, opportunities for scientific presentation, and training in standards for professional conduct. In Year 1, students take coursework and teaching duties in their home departments, and carry out laboratory rotations. At the end of Year 1, students choose a thesis advisor and elect to join this training program. In Year 2, students begin research and take elective coursework tailored to this program. Written and oral cumulative exams including the defense of a dissertation research proposal are required to advance to Ph.D. candidacy. In Years 3 and beyond, students obtain high caliber research training through the thesis project, with progress monitored yearly until graduation. Students add to their breadth and knowledge by participating in program symposia, supergroups, journal clubs, and seminars, and by presenting their work before large audiences. Students complete the program by defending a doctoral dissertation and receive a Ph.D. degree in Biochemistry or MCDB. Most students finish within 6 years of matriculation, and go on to postdoctoral training and careers in academia, research institutes, or pharmaceutical/biotechnology companies.
    4 schema:endDate 2021-06-30
    5 schema:funder grid-institutes:grid.280785.0
    6 schema:identifier N51ae2eac181244459758101daeb1e25b
    7 N9bb436a87b0041638f08d19383ec16d4
    8 schema:inLanguage en
    9 schema:keywords Department
    10 Department of Chemistry
    11 Department of Molecular
    12 Home Department
    13 Institute
    14 MCDB
    15 Ph.D. degree
    16 Research Institute
    17 Supergroup
    18 academia
    19 advisors
    20 analysis
    21 audience
    22 biochemistry
    23 biological information
    24 biological pathways
    25 biology
    26 biotechnology companies
    27 breadth
    28 candidacy
    29 career
    30 cell regulatory mechanisms
    31 cellular
    32 cellular regulation
    33 changes
    34 characterization
    35 chemistry
    36 classroom teaching
    37 clubs
    38 companies
    39 complex biological pathways
    40 components
    41 computational analysis
    42 conduct
    43 conformational changes
    44 coursework
    45 cumulative exam
    46 data evaluation
    47 defense
    48 degree
    49 description
    50 design
    51 developmental biology
    52 disciplines
    53 discovery
    54 disease
    55 dissertation
    56 doctoral dissertation
    57 duty
    58 elect
    59 elective coursework
    60 end
    61 evaluation
    62 exam
    63 experimental design
    64 exposure
    65 faculty
    66 field
    67 formulation
    68 goal
    69 graduation
    70 grant proposals
    71 group
    72 groups of investigators
    73 human diseases
    74 information
    75 investigators
    76 journal club
    77 key component
    78 knowledge
    79 laboratory rotation
    80 large audience
    81 mathematical modeling
    82 matriculation
    83 mechanism
    84 modeling
    85 modification
    86 molecular
    87 most students
    88 new therapeutic strategies
    89 opportunities
    90 pathway
    91 pharmaceutical/biotechnology companies
    92 postdoctoral training
    93 posttranslational modifications
    94 predoctoral trainees
    95 predoctoral training
    96 presentation
    97 productive research career
    98 professional conduct
    99 program
    100 progress
    101 project
    102 proposal
    103 protein conformational changes
    104 range
    105 regulation
    106 regulatory mechanisms
    107 research
    108 research career
    109 research proposals
    110 research training
    111 rigorous training
    112 rotation
    113 scientific disciplines
    114 scientific presentations
    115 scientific techniques
    116 seminars
    117 signaling
    118 standards
    119 strategies
    120 students
    121 symposium
    122 teaching
    123 teaching duties
    124 technique
    125 therapeutic strategies
    126 thesis advisor
    127 thesis project
    128 trainees
    129 training
    130 training faculty
    131 training program
    132 transfer
    133 wide range
    134 work
    135 year 1
    136 year 2
    137 year 3
    138 years
    139 years of matriculation
    140 schema:name Predoctoral Training in Signaling and Cellular Regulation
    141 schema:recipient N5fdf16a951cb4399bcc5ea5420e364fb
    142 sg:person.0577516710.65
    143 grid-institutes:grid.266190.a
    144 schema:sameAs https://app.dimensions.ai/details/grant/grant.2684042
    145 schema:sdDatePublished 2022-01-01T19:29
    146 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    147 schema:sdPublisher N61440af87f0b458497c6d144d0fa81a4
    148 schema:startDate 2000-07-01
    149 schema:url http://projectreporter.nih.gov/project_info_description.cfm?aid=9959417
    150 sgo:license sg:explorer/license/
    151 sgo:sdDataset grants
    152 rdf:type schema:MonetaryGrant
    153 N51ae2eac181244459758101daeb1e25b schema:name dimensions_id
    154 schema:value grant.2684042
    155 rdf:type schema:PropertyValue
    156 N5fdf16a951cb4399bcc5ea5420e364fb schema:member sg:person.0577516710.65
    157 schema:roleName PI
    158 rdf:type schema:Role
    159 N61440af87f0b458497c6d144d0fa81a4 schema:name Springer Nature - SN SciGraph project
    160 rdf:type schema:Organization
    161 N9bb436a87b0041638f08d19383ec16d4 schema:name nih_id
    162 schema:value T32GM008759
    163 rdf:type schema:PropertyValue
    164 Nf9d9f87e698d43a6ad428b867be4e493 schema:currency USD
    165 schema:value 5910792.0
    166 rdf:type schema:MonetaryAmount
    167 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    168 rdf:type schema:DefinedTerm
    169 sg:person.0577516710.65 schema:affiliation grid-institutes:None
    170 schema:familyName AHN
    171 schema:givenName NATALIE G
    172 rdf:type schema:Person
    173 grid-institutes:None schema:name UNIVERSITY OF COLORADO
    174 rdf:type schema:Organization
    175 grid-institutes:grid.266190.a schema:Organization
    176 grid-institutes:grid.280785.0 schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...