Peripheral and central Postural Disorders in the Elderly View Homepage


Ontology type: schema:MonetaryGrant     


Grant Info

YEARS

1989-2015

FUNDING AMOUNT

4462705 USD

ABSTRACT

The extent to which basal ganglia disorders of postural controlare associated with abnormal central processing of somatosensory information for an internal representation of body position and motion (kinesthesia) is unknown. This project seeks to determine how kinesthetic information is used for postural control in healthy elderly subjects and subjects with Parkinson's disease (PD), a basal ganglia disorder. Both subjective measures (psychophysical) and objective measures (surface reactive forces, kinematic body CoM displacement, and muscle activation) will be used to quantify disorders of kinesthetic integration for postural control in subjects with PD compared to age-matched control subjects. Standing and sitting postural control will be examined because of stance and axial postural problems associated with PD. All studies will test subjects with PD in the ON and OFF states to examine the effects of levodopa replacement on kinesthetic control of posture. The specific aims address 3 roles of kinesthetic information for the control of posture: Aim I. Determine how PD affects perception of distal and proximal joint position sense and perception of postural verticality. Exp. 1 will test the hypothesis that the basal ganglia are important for conscious ankle and torso kinesthesia in stance posture. Exp. 2 will test the hypothesis that the basal ganglia integrate vestibular and somatosensory information to provide an internal representation of postural vertical. Aim I1. Determine whether PD impairs use of somatosensory graviception as a postural reference. Exps. 3 and 4 will test the hypothesis that PD is associated with impaired use of slow, graviceptive somatosensory information, which normally provides a reference or 'set' point for postural orientation to vertical. Aim II1. Define how PD impairs movement-related kinesthetic information for compensatory stepping. Exp 5 and 6 will test the hypothesis that impaired kinesthesia from the legs and falling body results in increased dependence on vision for accurate compensatory stepping to recover equilbrium. Effective rehabilitation of balance disorders requires a better understanding of how kinesthetic information is used for joint alignment, postural verticality, postural orientation, and control of postural equilibrium responses. More... »

URL

http://projectreporter.nih.gov/project_info_description.cfm?aid=8448665

Related SciGraph Publications

  • 2016-06. More Falls in Cerebellar Ataxia When Standing on a Slow Up-Moving Tilt of the Support Surface in THE CEREBELLUM
  • 2013-08. Accelerometry Reveals Differences in Gait Variability Between Patients with Multiple Sclerosis and Healthy Controls in ANNALS OF BIOMEDICAL ENGINEERING
  • 2012-12. ISway: a sensitive, valid and reliable measure of postural control in JOURNAL OF NEUROENGINEERING AND REHABILITATION
  • 2012-12. Comparison of tai chi vs. strength training for fall prevention among female cancer survivors: study protocol for the GET FIT trial in BMC CANCER
  • 2012-11. Keeping your balance while balancing a cylinder: interaction between postural and voluntary goals in EXPERIMENTAL BRAIN RESEARCH
  • 2012-10. Effects of magnitude and magnitude predictability of postural perturbations on preparatory cortical activity in older adults with and without Parkinson’s disease in EXPERIMENTAL BRAIN RESEARCH
  • 2012-05. Linear and angular control of circular walking in healthy older adults and subjects with cerebellar ataxia in EXPERIMENTAL BRAIN RESEARCH
  • 2011-08. Postural control deficits in people with fibromyalgia: a pilot study in ARTHRITIS RESEARCH & THERAPY
  • 2011-02. Podokinetic stimulation causes shifts in perception of straight ahead in EXPERIMENTAL BRAIN RESEARCH
  • 2010-08. Aging does not affect generalized postural motor learning in response to variable amplitude oscillations of the support surface in EXPERIMENTAL BRAIN RESEARCH
  • 2010-05. Influence of vision on adaptive postural responses following standing on an incline in EXPERIMENTAL BRAIN RESEARCH
  • 2009-11. Practice-related improvements in posture control differ between young and older adults exposed to continuous, variable amplitude oscillations of the support surface in EXPERIMENTAL BRAIN RESEARCH
  • 2008-06. Compensatory postural adaptations during continuous, variable amplitude perturbations reveal generalized rather than sequence-specific learning in EXPERIMENTAL BRAIN RESEARCH
  • 2007-10. Cortical control of postural responses in JOURNAL OF NEURAL TRANSMISSION
  • 2007-05. External postural perturbations induce multiple anticipatory postural adjustments when subjects cannot pre-select their stepping foot in EXPERIMENTAL BRAIN RESEARCH
  • 2007-03. Adaptation of postural orientation to changes in surface inclination in EXPERIMENTAL BRAIN RESEARCH
  • 2006-11. An alternative clinical postural stability test for patients with Parkinson’s disease in JOURNAL OF NEUROLOGY
  • 2006-02. Interaction of involuntary post-contraction activity with locomotor movements in EXPERIMENTAL BRAIN RESEARCH
  • 2005-12. Influence of a portable audio-biofeedback device on structural properties of postural sway in JOURNAL OF NEUROENGINEERING AND REHABILITATION
  • 2005-11. Feedback equilibrium control during human standing in BIOLOGICAL CYBERNETICS
  • 2005-09. Can stooped posture explain multidirectional postural instability in patients with Parkinson’s disease? in EXPERIMENTAL BRAIN RESEARCH
  • 2004-05. Abnormal force patterns for multidirectional postural responses in patients with Parkinson’s disease in EXPERIMENTAL BRAIN RESEARCH
  • 2002. Vestibulospinal Control of Posture in SENSORIMOTOR CONTROL OF MOVEMENT AND POSTURE
  • 1994-09. The importance of somatosensory information in triggering and scaling automatic postural responses in humans in EXPERIMENTAL BRAIN RESEARCH
  • 1994-07. Vestibular and somatosensory contributions to responses to head and body displacements in stance in EXPERIMENTAL BRAIN RESEARCH
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