Primary Infection Resource Consortium (PIRC) View Homepage


Ontology type: schema:MonetaryGrant     


Grant Info

YEARS

2013-2022

FUNDING AMOUNT

12921528 USD

ABSTRACT

ABSTRACT HIV incidence is still increasing in the U.S. despite intense efforts to: (i) diagnose HIV infection as early as possible, (ii) engage newly diagnosed individuals into care and (iii) start antiretroviral therapy (ART) for all infected persons. The San Diego Primary Infection Resource Consortium (PIRC) has been tackling the evolving challenges around these issues for twenty years. The PIRC is the largest, most intensively studied and well-characterized cohort of acute and early HIV infected (AEH) individuals in the United States. It has provided essential support to over 325 peer-reviewed original research manuscripts, spanning a wide range of fields, and including many NIH priority areas for HIV research, including: HIV incidence, strategies to improve HIV testing and entry into prevention services, etc. This application represents a renewal of our PIRC R24 (AI106039) with the proposal to continue this highly productive program, supporting the infrastructure needed to identify, characterize, and share clinical and biological data with scientific colleagues whose research objectives rely upon access to these biological samples and data. The proposed R24 renewal application includes a new collaboration between PIRC and the Center for AIDS Research (CFAR) Network of Integrated Clinical Systems (CNICS) to develop an expanded and synergistic resource to serve biomedical research in the area of AEH. Overall, the PIRC supports: 1) an HIV screening program to detect and stage acute, recent and chronic infection, 2) partner services to identify sexual contacts of newly HIV diagnosed AEH participants (i.e., ?index? subjects), 3) immediate provision of ART, 4) prompt linkage to care, 5) monitoring of ART adherence and continued engagement in care, 6) methods to estimate putative HIV transmission and 6) an AEH biorepository. This entire biorepository and data associated with these well characterized participants are available to qualified investigators, requiring only internal review and approval of a concept proposal. The proposed R24 renewal application will address the following Specific Aims: Aim 1. Community HIV Testing and Acute and Early HIV (AEH) Infection Staging. We propose to identify 120 newly HIV diagnosed persons per year at the University of California San Diego: 47 AEH infected and 73 chronically infected participants. Aim 2. Improve Continuum of HIV Prevention and Treatment. We will evaluate temporal changes in the HIV treatment cascade in response to coordinated efforts to support immediate ART in newly HIV diagnosed PIRC participants. Subjects identified during AEH will be followed for up to 5 years, while chronically infected subjects will be followed in clinic for up to 90 days. Aim 3. Shared Resources. We will leverage AEH specimen and participant resources to support additional NIH research collaborations related to primary HIV infection. Co-enrollment of AEH participants in CNICS will leverage the clinical monitoring of validated outcomes and longitudinal resistance data provided by CNICS. The PIRC will serve as a resource to support high quality basic, clinical and translational research related to AEH. More... »

URL

http://projectreporter.nih.gov/project_info_description.cfm?aid=9547753

Related SciGraph Publications

  • 2019-01-07. Self-initiated continuation of and adherence to HIV pre-exposure prophylaxis (PrEP) after PrEP demonstration project roll-off in men who have sex with men: associations with risky decision making, impulsivity/disinhibition, and sensation seeking in JOURNAL OF NEUROVIROLOGY
  • 2018-12. Molecular Epidemiology of the HIV Epidemic in Three German Metropolitan Regions – Cologne/Bonn, Munich and Hannover, 1999–2016 in SCIENTIFIC REPORTS
  • 2017-12. Risk profile and HIV testing outcomes of women undergoing community-based testing in San Diego 2008–2014 in SCIENTIFIC REPORTS
  • 2017-10. Sexual Partner Concurrency Among Partners Reported by MSM with Recent HIV Infection in AIDS AND BEHAVIOR
  • 2016-12. Rapid HIV Viral Load Suppression in those Initiating Antiretroviral Therapy at First Visit after HIV Diagnosis in SCIENTIFIC REPORTS
  • 2016-09. HIV Infection Rates and Risk Behavior among Young Men undergoing community-based Testing in San Diego in SCIENTIFIC REPORTS
  • 2016-09. A practical online tool to estimate antiretroviral coverage for HIV infected and susceptible populations needed to reduce local HIV epidemics in SCIENTIFIC REPORTS
  • 2016-02. Partners in Crime: The Role of CMV in Immune Dysregulation and Clinical Outcome During HIV Infection in CURRENT HIV/AIDS REPORTS
  • 2016-01. Gut dendritic cell activation links an altered colonic microbiome to mucosal and systemic T-cell activation in untreated HIV-1 infection in MUCOSAL IMMUNOLOGY
  • 2015-12. Genital Epstein Barr Virus is associated with higher prevalence and persistence of anal human papillomavirus in HIV-infected men on antiretroviral therapy in BMC INFECTIOUS DISEASES
  • 2015-12. Repeat HIV-testing is associated with an increase in behavioral risk among men who have sex with men: a cohort study in BMC MEDICINE
  • 2015-12. Circulating HIV DNA Correlates With Neurocognitive Impairment in Older HIV-infected Adults on Suppressive ART in SCIENTIFIC REPORTS
  • 2015-10. Methamphetamine Use in HIV-infected Individuals Affects T-cell Function and Viral Outcome during Suppressive Antiretroviral Therapy in SCIENTIFIC REPORTS
  • 2014-09. Pre-Exposure Prophylaxis Accessibility Research and Evaluation (PrEPARE Study) in AIDS AND BEHAVIOR
  • 2014-08. Modeling the Impact of Post-Diagnosis Behavior Change on HIV Prevalence in Southern California Men Who Have Sex with Men (MSM) in AIDS AND BEHAVIOR
  • 2013-12. Real-world impact of neurocognitive deficits in acute and early HIV infection in JOURNAL OF NEUROVIROLOGY
  • 2013-10. Dual-mixed HIV-1 coreceptor tropism and HIV-associated neurocognitive deficits in JOURNAL OF NEUROVIROLOGY
  • 2013-02. Substance use is a risk factor for neurocognitive deficits and neuropsychiatric distress in acute and early HIV infection in JOURNAL OF NEUROVIROLOGY
  • 2013-02. Cell-intrinsic mechanism involving Siglec-5 associated with divergent outcomes of HIV-1 infection in human and chimpanzee CD4 T cells in JOURNAL OF MOLECULAR MEDICINE
  • 2012-04. Genetic features of cerebrospinal fluid-derived subtype B HIV-1 tat in JOURNAL OF NEUROVIROLOGY
  • 2011-10. High-Risk Behaviors Associated with Injection Drug Use Among Recently HIV-Infected Men Who Have Sex with Men in San Diego, CA in AIDS AND BEHAVIOR
  • 2011-02. Neurocognitive functioning in acute or early HIV infection in JOURNAL OF NEUROVIROLOGY
  • 2009-04. Associations Between Substance Use, Erectile Dysfunction Medication and Recent HIV Infection Among Men Who have Sex with Men in AIDS AND BEHAVIOR
  • 2008-04. CCL3L1-CCR5 genotype influences durability of immune recovery during antiretroviral therapy of HIV-1–infected individuals in NATURE MEDICINE
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