Obesity Genes, Energy Regulation in Response to Weight-Loss Diets View Homepage


Ontology type: schema:MonetaryGrant     


Grant Info

YEARS

2012-2022

FUNDING AMOUNT

2610055 USD

ABSTRACT

Considerable interpersonal variability in weight loss exists in diet interventions, likely due to individuals' inherent factors such as genomic and epigenomic variations; however our currently knowledge on these factors is extremely poor. The proposed systems study aims to fill this significant research gap. In three independent, comprehensive comparator trials on weight-loss diets ? POUNDS LOST, DIRECT and MACRO, we propose to perform thus far the most comprehensive epigenome-wide association study (EWAS) using state-of-the-art capture-based bisulfite sequencing approach (targeting ~5M dynamic CpGs) to identify DNA methylation (DNAm) associated with long-term (up to 2 years) weight loss in response to diet interventions (Aim 1a and 1b), and assess the dietary effects on dynamic changes in DNAm (Aim 1c). We will develop joint DNAm Scores (MeS) integrating methylation information across CpG sites, and analyze their associations with weight loss (Aim 2). We will also examine the relations between DNAm and markers of energy balance (Aim 3). In addition, we will apply newly-developed multi-omics algorithm to predict weight loss, by integrating DNAm with genomics, metabolomics, biochemical and clinical measures (Aim 4). We believe that our study will provide novel insights into the roles of epigenomics and multi-omics in determining weight loss in response to diet interventions, and contribute significantly to improve efficiency of precision obesity management. More... »

URL

http://projectreporter.nih.gov/project_info_description.cfm?aid=9594342

Related SciGraph Publications

  • 2018-09. Gut-microbiome-related LCT genotype and 2-year changes in body composition and fat distribution: the POUNDS Lost Trial in INTERNATIONAL JOURNAL OF OBESITY
  • 2018-03-07. A circadian rhythm-related MTNR1B genetic variant modulates the effect of weight-loss diets on changes in adiposity and body composition: the POUNDS Lost trial in EUROPEAN JOURNAL OF NUTRITION
  • 2018-02. Sugar-sweetened beverage intake associations with fasting glucose and insulin concentrations are not modified by selected genetic variants in a ChREBP-FGF21 pathway: a meta-analysis in DIABETOLOGIA
  • 2018-01. Birthweight and cardiometabolic risk patterns in multiracial children in INTERNATIONAL JOURNAL OF OBESITY
  • 2017-12. A Systems Genetics Approach Identified GPD1L and its Molecular Mechanism for Obesity in Human Adipose Tissue in SCIENTIFIC REPORTS
  • 2017-12. Habitual coffee consumption and genetic predisposition to obesity: gene-diet interaction analyses in three US prospective studies in BMC MEDICINE
  • 2017-12. Gallstone Disease and the Risk of Type 2 Diabetes in SCIENTIFIC REPORTS
  • 2017-12. The MC4R genotype is associated with postpartum weight reduction and glycemic changes among women with prior gestational diabetes: longitudinal analysis in SCIENTIFIC REPORTS
  • 2017-04-26. Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits in NATURE COMMUNICATIONS
  • 2016-12. Associations of Bowel Movement Frequency with Risk of Cardiovascular Disease and Mortality among US Women in SCIENTIFIC REPORTS
  • 2016-11. Two-year changes in circulating adiponectin, ectopic fat distribution and body composition in response to weight-loss diets: the POUNDS Lost Trial in INTERNATIONAL JOURNAL OF OBESITY
  • 2016-09. Low birthweight and risk of type 2 diabetes: a Mendelian randomisation study in DIABETOLOGIA
  • 2016-07. Genetic variation of fasting glucose and changes in glycemia in response to 2-year weight-loss diet intervention: the POUNDS LOST trial in INTERNATIONAL JOURNAL OF OBESITY
  • 2016. Nutrigenetics of Type 2 Diabetes in THE GENETICS OF TYPE 2 DIABETES AND RELATED TRAITS
  • 2015-12. Vitamin D metabolism-related genetic variants, dietary protein intake and improvement of insulin resistance in a 2 year weight-loss trial: POUNDS Lost in DIABETOLOGIA
  • 2015-12. Joint association between birth weight at term and later life adherence to a healthy lifestyle with risk of hypertension: a prospective cohort study in BMC MEDICINE
  • 2015-12. Consumption of whole grains and cereal fiber and total and cause-specific mortality: prospective analysis of 367,442 individuals in BMC MEDICINE
  • 2014-12. Neck circumference and early stage atherosclerosis: the cardiometabolic risk in Chinese (CRC) study in CARDIOVASCULAR DIABETOLOGY
  • 2014-12. Circulating adiponectin and cardiovascular mortality in patients with type 2 diabetes mellitus: evidence of sexual dimorphism in CARDIOVASCULAR DIABETOLOGY
  • 2014-12. Synergistic effects of neck circumference and metabolic risk factors on insulin resistance: the Cardiometabolic Risk in Chinese (CRC) study in DIABETOLOGY & METABOLIC SYNDROME
  • 2012-12. Gene-Diet Interactions in Complex Disease: Current Findings and Relevance for Public Health in CURRENT NUTRITION REPORTS
  • 2010-10. Hundreds of variants clustered in genomic loci and biological pathways affect human height in NATURE
  • 2010-02. Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge in NATURE GENETICS
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