2007-2013
FUNDING AMOUNT2024957 USD
ABSTRACTThe adverse consequences of obesity are pleiotrophic for the mammalian organism. Animal models of obesity that allow careful characterization of the pervasive metabolic effects of the disease are vital to the success of our mission. To enhance research into the causes and consequences of obesity, we established a mouse phenotyping core. The primary goals of this core are to develop and provide standardized state-ofthe- art methods for the analysis of animal models of disease. The core applies the analytical expertise of ten laboratories to provide histology, neuroanatomy, gene expression, mass spectrometry, physiology, lipid, glucose, metabokine, and behavioral assays. The core is directed by Russell, Elmquist, and Scherer and is staffed by a dedicated team of skilled technicians who utilize existing equipment to perform optimized assays on samples provided by TORS investigators. Currently available assays include histological staining and antigen detection, in situ mRNA hybridization, real time reverse transcriptase-PCR, microarray analysis, laser capture microdissection, small molecule mass spectrometry and metabolite profiling, metabolic cage analyses, complete lipid balance studies, magnetic resonance and computed tomography imaging, glucose tolerance and clamp analyses, serum hormone measurements, routine blood chemistries, exhaustive behavioral analyses, and synaptic plasticity measurements in brain slices. As new research findings dictate, novel methodologies are developed and made available by the core. For each experiment, results are collected, calculated, and compiled in electronic format and returned to submitting investigators. The availability of the services provided by this core accelerates the pace of our research, allows centralized troubleshooting, and facilitates the efficient utilization of existing expertise and resources. The mouse phenotyping core is a crucial component of our Roadmap effort that brings together a diverse team of scientists and clinicians to ensure that discoveries made in obesity research are rapidly translated into advances in patient care. More... »
URLhttp://projectreporter.nih.gov/project_info_description.cfm?aid=8139678
http://scigraph.springernature.com/grant.2441311
DIMENSIONShttps://app.dimensions.ai/details/grant/grant.2441311
NIHPL1DK081182
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/2203",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"type": "DefinedTerm"
}
],
"amount": {
"currency": "USD",
"type": "MonetaryAmount",
"value": "2024957"
},
"description": "The adverse consequences of obesity are pleiotrophic for the mammalian organism. Animal models of obesity that allow careful characterization of the pervasive metabolic effects of the disease are vital to the success of our mission. To enhance research into the causes and consequences of obesity, we established a mouse phenotyping core. The primary goals of this core are to develop and provide standardized state-ofthe- art methods for the analysis of animal models of disease. The core applies the analytical expertise of ten laboratories to provide histology, neuroanatomy, gene expression, mass spectrometry, physiology, lipid, glucose, metabokine, and behavioral assays. The core is directed by Russell, Elmquist, and Scherer and is staffed by a dedicated team of skilled technicians who utilize existing equipment to perform optimized assays on samples provided by TORS investigators. Currently available assays include histological staining and antigen detection, in situ mRNA hybridization, real time reverse transcriptase-PCR, microarray analysis, laser capture microdissection, small molecule mass spectrometry and metabolite profiling, metabolic cage analyses, complete lipid balance studies, magnetic resonance and computed tomography imaging, glucose tolerance and clamp analyses, serum hormone measurements, routine blood chemistries, exhaustive behavioral analyses, and synaptic plasticity measurements in brain slices. As new research findings dictate, novel methodologies are developed and made available by the core. For each experiment, results are collected, calculated, and compiled in electronic format and returned to submitting investigators. The availability of the services provided by this core accelerates the pace of our research, allows centralized troubleshooting, and facilitates the efficient utilization of existing expertise and resources. The mouse phenotyping core is a crucial component of our Roadmap effort that brings together a diverse team of scientists and clinicians to ensure that discoveries made in obesity research are rapidly translated into advances in patient care.",
"endDate": "2013-06-30T00:00:00Z",
"funder": {
"id": "https://www.grid.ac/institutes/grid.419635.c",
"type": "Organization"
},
"id": "sg:grant.2441311",
"identifier": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"2441311"
]
},
{
"name": "nih_id",
"type": "PropertyValue",
"value": [
"PL1DK081182"
]
}
],
"inLanguage": [
"en"
],
"keywords": [
"magnetic resonance",
"lipids",
"equipment",
"mice",
"microarray analysis",
"new research findings",
"scientists",
"analysis",
"analytical expertise",
"success",
"consequence",
"available assays",
"synaptic plasticity measurements",
"expertise",
"complete lipid balance studies",
"metabokine",
"routine blood chemistry",
"standardized state-ofthe- art methods",
"cause",
"diverse teams",
"experiments",
"TORS investigators",
"research",
"histology",
"Scherer",
"assay",
"skilled technicians",
"resources",
"centralized troubleshooting",
"tomography imaging",
"services",
"patient care",
"obesity research",
"small molecule mass spectrometry",
"primary goal",
"glucose",
"disease",
"dedicated team",
"Project 9",
"mammalian organisms",
"core",
"metabolic cage analysis",
"laboratory",
"electronic format",
"Mouse Phenotype Core",
"careful characterization",
"results",
"clinicians",
"adverse consequences",
"samples",
"mission",
"Elmquist",
"efficient utilization",
"brain slices",
"metabolite profiling",
"discovery",
"serum hormone measurements",
"obesity",
"availability",
"clamp analysis",
"laser capture microdissection",
"investigators",
"exhaustive behavioral analyses",
"neuroanatomy",
"gene expression",
"Russell",
"novel methodology",
"situ mRNA hybridization",
"Roadmap effort",
"mass spectrometry",
"antigen detection",
"pervasive metabolic effects",
"advances",
"physiology",
"glucose tolerance",
"real time reverse transcriptase-PCR",
"behavioral assays",
"pace",
"animal models",
"crucial component"
],
"name": "Mouse Phenotype Core, Project 9 of 10",
"recipient": [
{
"id": "https://www.grid.ac/institutes/grid.267313.2",
"type": "Organization"
},
{
"affiliation": {
"id": "https://www.grid.ac/institutes/grid.267313.2",
"name": "UT SOUTHWESTERN MEDICAL CENTER",
"type": "Organization"
},
"familyName": "RUSSELL",
"givenName": "DAVID W.",
"id": "sg:person.010774400042.50",
"type": "Person"
},
{
"member": "sg:person.010774400042.50",
"roleName": "PI",
"type": "Role"
}
],
"sameAs": [
"https://app.dimensions.ai/details/grant/grant.2441311"
],
"sdDataset": "grants",
"sdDatePublished": "2019-03-07T12:12",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com.uberresearch.data.processor/core_data/20181219_192338/projects/base/nih_projects_5.xml.gz",
"startDate": "2007-09-30T00:00:00Z",
"type": "MonetaryGrant",
"url": "http://projectreporter.nih.gov/project_info_description.cfm?aid=8139678"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/grant.2441311'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/grant.2441311'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/grant.2441311'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/grant.2441311'
This table displays all metadata directly associated to this object as RDF triples.
124 TRIPLES
19 PREDICATES
102 URIs
94 LITERALS
5 BLANK NODES
Subject | Predicate | Object | |
---|---|---|---|
1 | sg:grant.2441311 | schema:about | anzsrc-for:2203 |
2 | ″ | schema:amount | Nca049d8adc8548759f1b85288984d7fb |
3 | ″ | schema:description | The adverse consequences of obesity are pleiotrophic for the mammalian organism. Animal models of obesity that allow careful characterization of the pervasive metabolic effects of the disease are vital to the success of our mission. To enhance research into the causes and consequences of obesity, we established a mouse phenotyping core. The primary goals of this core are to develop and provide standardized state-ofthe- art methods for the analysis of animal models of disease. The core applies the analytical expertise of ten laboratories to provide histology, neuroanatomy, gene expression, mass spectrometry, physiology, lipid, glucose, metabokine, and behavioral assays. The core is directed by Russell, Elmquist, and Scherer and is staffed by a dedicated team of skilled technicians who utilize existing equipment to perform optimized assays on samples provided by TORS investigators. Currently available assays include histological staining and antigen detection, in situ mRNA hybridization, real time reverse transcriptase-PCR, microarray analysis, laser capture microdissection, small molecule mass spectrometry and metabolite profiling, metabolic cage analyses, complete lipid balance studies, magnetic resonance and computed tomography imaging, glucose tolerance and clamp analyses, serum hormone measurements, routine blood chemistries, exhaustive behavioral analyses, and synaptic plasticity measurements in brain slices. As new research findings dictate, novel methodologies are developed and made available by the core. For each experiment, results are collected, calculated, and compiled in electronic format and returned to submitting investigators. The availability of the services provided by this core accelerates the pace of our research, allows centralized troubleshooting, and facilitates the efficient utilization of existing expertise and resources. The mouse phenotyping core is a crucial component of our Roadmap effort that brings together a diverse team of scientists and clinicians to ensure that discoveries made in obesity research are rapidly translated into advances in patient care. |
4 | ″ | schema:endDate | 2013-06-30T00:00:00Z |
5 | ″ | schema:funder | https://www.grid.ac/institutes/grid.419635.c |
6 | ″ | schema:identifier | N1c3c9be07789407cbeead4c28f60e132 |
7 | ″ | ″ | Nf036ee36956b401db9951cba4b5b3031 |
8 | ″ | schema:inLanguage | en |
9 | ″ | schema:keywords | Elmquist |
10 | ″ | ″ | Mouse Phenotype Core |
11 | ″ | ″ | Project 9 |
12 | ″ | ″ | Roadmap effort |
13 | ″ | ″ | Russell |
14 | ″ | ″ | Scherer |
15 | ″ | ″ | TORS investigators |
16 | ″ | ″ | advances |
17 | ″ | ″ | adverse consequences |
18 | ″ | ″ | analysis |
19 | ″ | ″ | analytical expertise |
20 | ″ | ″ | animal models |
21 | ″ | ″ | antigen detection |
22 | ″ | ″ | assay |
23 | ″ | ″ | availability |
24 | ″ | ″ | available assays |
25 | ″ | ″ | behavioral assays |
26 | ″ | ″ | brain slices |
27 | ″ | ″ | careful characterization |
28 | ″ | ″ | cause |
29 | ″ | ″ | centralized troubleshooting |
30 | ″ | ″ | clamp analysis |
31 | ″ | ″ | clinicians |
32 | ″ | ″ | complete lipid balance studies |
33 | ″ | ″ | consequence |
34 | ″ | ″ | core |
35 | ″ | ″ | crucial component |
36 | ″ | ″ | dedicated team |
37 | ″ | ″ | discovery |
38 | ″ | ″ | disease |
39 | ″ | ″ | diverse teams |
40 | ″ | ″ | efficient utilization |
41 | ″ | ″ | electronic format |
42 | ″ | ″ | equipment |
43 | ″ | ″ | exhaustive behavioral analyses |
44 | ″ | ″ | experiments |
45 | ″ | ″ | expertise |
46 | ″ | ″ | gene expression |
47 | ″ | ″ | glucose |
48 | ″ | ″ | glucose tolerance |
49 | ″ | ″ | histology |
50 | ″ | ″ | investigators |
51 | ″ | ″ | laboratory |
52 | ″ | ″ | laser capture microdissection |
53 | ″ | ″ | lipids |
54 | ″ | ″ | magnetic resonance |
55 | ″ | ″ | mammalian organisms |
56 | ″ | ″ | mass spectrometry |
57 | ″ | ″ | metabokine |
58 | ″ | ″ | metabolic cage analysis |
59 | ″ | ″ | metabolite profiling |
60 | ″ | ″ | mice |
61 | ″ | ″ | microarray analysis |
62 | ″ | ″ | mission |
63 | ″ | ″ | neuroanatomy |
64 | ″ | ″ | new research findings |
65 | ″ | ″ | novel methodology |
66 | ″ | ″ | obesity |
67 | ″ | ″ | obesity research |
68 | ″ | ″ | pace |
69 | ″ | ″ | patient care |
70 | ″ | ″ | pervasive metabolic effects |
71 | ″ | ″ | physiology |
72 | ″ | ″ | primary goal |
73 | ″ | ″ | real time reverse transcriptase-PCR |
74 | ″ | ″ | research |
75 | ″ | ″ | resources |
76 | ″ | ″ | results |
77 | ″ | ″ | routine blood chemistry |
78 | ″ | ″ | samples |
79 | ″ | ″ | scientists |
80 | ″ | ″ | serum hormone measurements |
81 | ″ | ″ | services |
82 | ″ | ″ | situ mRNA hybridization |
83 | ″ | ″ | skilled technicians |
84 | ″ | ″ | small molecule mass spectrometry |
85 | ″ | ″ | standardized state-ofthe- art methods |
86 | ″ | ″ | success |
87 | ″ | ″ | synaptic plasticity measurements |
88 | ″ | ″ | tomography imaging |
89 | ″ | schema:name | Mouse Phenotype Core, Project 9 of 10 |
90 | ″ | schema:recipient | Nb0c9cf4bb2b94a7c900a7d6f6deaa06a |
91 | ″ | ″ | sg:person.010774400042.50 |
92 | ″ | ″ | https://www.grid.ac/institutes/grid.267313.2 |
93 | ″ | schema:sameAs | https://app.dimensions.ai/details/grant/grant.2441311 |
94 | ″ | schema:sdDatePublished | 2019-03-07T12:12 |
95 | ″ | schema:sdLicense | https://scigraph.springernature.com/explorer/license/ |
96 | ″ | schema:sdPublisher | Ndbdf279723ee41a9afceaf664f0ac8cd |
97 | ″ | schema:startDate | 2007-09-30T00:00:00Z |
98 | ″ | schema:url | http://projectreporter.nih.gov/project_info_description.cfm?aid=8139678 |
99 | ″ | sgo:license | sg:explorer/license/ |
100 | ″ | sgo:sdDataset | grants |
101 | ″ | rdf:type | schema:MonetaryGrant |
102 | N1c3c9be07789407cbeead4c28f60e132 | schema:name | nih_id |
103 | ″ | schema:value | PL1DK081182 |
104 | ″ | rdf:type | schema:PropertyValue |
105 | Nb0c9cf4bb2b94a7c900a7d6f6deaa06a | schema:member | sg:person.010774400042.50 |
106 | ″ | schema:roleName | PI |
107 | ″ | rdf:type | schema:Role |
108 | Nca049d8adc8548759f1b85288984d7fb | schema:currency | USD |
109 | ″ | schema:value | 2024957 |
110 | ″ | rdf:type | schema:MonetaryAmount |
111 | Ndbdf279723ee41a9afceaf664f0ac8cd | schema:name | Springer Nature - SN SciGraph project |
112 | ″ | rdf:type | schema:Organization |
113 | Nf036ee36956b401db9951cba4b5b3031 | schema:name | dimensions_id |
114 | ″ | schema:value | 2441311 |
115 | ″ | rdf:type | schema:PropertyValue |
116 | anzsrc-for:2203 | schema:inDefinedTermSet | anzsrc-for: |
117 | ″ | rdf:type | schema:DefinedTerm |
118 | sg:person.010774400042.50 | schema:affiliation | https://www.grid.ac/institutes/grid.267313.2 |
119 | ″ | schema:familyName | RUSSELL |
120 | ″ | schema:givenName | DAVID W. |
121 | ″ | rdf:type | schema:Person |
122 | https://www.grid.ac/institutes/grid.267313.2 | schema:name | UT SOUTHWESTERN MEDICAL CENTER |
123 | ″ | rdf:type | schema:Organization |
124 | https://www.grid.ac/institutes/grid.419635.c | ″ | schema:Organization |