Cardiovascular Benefits Of Soy Phytoestrogens View Homepage


Ontology type: schema:MonetaryGrant     


Grant Info

YEARS

1991-2007

FUNDING AMOUNT

10944433.0 USD

ABSTRACT

PROPOSED PROGRAM: (Adapted from Applicant's Abstract) This PPG continues to be a group of interrelated projects focused primarily on the potential cardiovascular benefits of soy phytoestrogen supplementation/treatment. Potential benefits of soy phytoestrogens (SPEs) for breast and uterus of females and of prostate of males constitute a secondary focus. The research is directed toward males and pre and postmenopausal females. In Project 1, the investigators will intensify their pharmacologic studies of the soy phytoestrogens (SPEs) by addressing four questions: 1. What is the peptide fraction of soy protein that is required for the phytoestrogens (isoflavones) to have their effect on lipid metabolism? 2. Are there differences in the effects of soy phytoestrogen preparations that are predominately genistein or predominately daidzein? 3. What is the relationship between dose of soy phytoestrogens and their metabolic effects? 4. What are the longer term effects of the "optimal" soy treatment? The major objective of Project 2 is to assess the usefulness of soy phytoestrogens in primary cardioprotection of adult male monkeys. Also, the study will address directly whether long-term soy consumption is without adverse effects on the reproductive system, cognition, social and sexual behavior and function and determine if it has favorable effects on the prostate gland. Postmortem assessments will be made of atherosclerosis extent and arterial expression of estrogen receptors (alpha and beta). In addition, immunohistochemical and histomorphometric markers of prostatic hyperplasia and neoplasia will be studied as will histomorphometric markers of mammary gland hyperplasia and neoplasia. Project 3 is a comprehensive, periclinical study that will determine whether treatment with SPEs inhibits the progression of coronary and carotid artery atherosclerosis and improves coronary artery dilator responses in high risk, subordinate premenopausal monkeys. Furthermore, the study will determine whether SPEs inhibit or potentiate proliferation and estrogenic responses in the endometrium and mammary tissue of premenopausal monkeys, and whether SPEs adversely affect or improve bone development and peak bone mass in these females. More... »

URL

http://projectreporter.nih.gov/project_info_description.cfm?aid=6731103

Related SciGraph Publications

  • 2008-07-07. Estrogen effects on epithelial proliferation and benign proliferative lesions in the postmenopausal primate mammary gland in LABORATORY INVESTIGATION
  • 2003-05. Effects of Long-Term HRT and Tamoxifen on the Expression of Progesterone Receptors A and B in Breast Tissue from Surgically Postmenopausal Cynomolgus Macaques in BREAST CANCER RESEARCH AND TREATMENT
  • 2003-01. Soy and social stress affect serotonin neurotransmission in primates in THE PHARMACOGENOMICS JOURNAL
  • 2001-07-27. Central Nervous System Monoamine Correlates of Social Dominance in Cynomolgus Monkeys (Macaca fascicularis) in NEUROPSYCHOPHARMACOLOGY
  • 2000-09. The Effect of Androstenedione/Estrone Supplementation on Cortical and Cancellous Bone in the Young Intact Female Monkey: A Model for the Effects of Polycystic Ovarian Disease on the Skeleton? in OSTEOPOROSIS INTERNATIONAL
  • 1999-05-26. Effects of hormone replacement therapy and social stress on body fat distribution in surgically postmenopausal monkeys in INTERNATIONAL JOURNAL OF OBESITY
  • 1999-01. p53 expression in breast and endometrium during estrogen and tamoxifen treatment of surgically postmenopausal cynomolgus macaques in BREAST CANCER RESEARCH AND TREATMENT
  • 1998-06. Soy Protein Isolate Diet Does Not Prevent Increased Cortical Bone Turnover in Ovariectomized Macaques in CALCIFIED TISSUE INTERNATIONAL
  • 1998-04. Effects of conjugated estrogens, medroxyprogesterone acetate, and tamoxifen on the mammary glands of macaques in BREAST CANCER RESEARCH AND TREATMENT
  • 1997-07. Oral contraceptive treatment inhibits the normal acquisition of bone mineral in skeletally immature young adult female monkeys in OSTEOPOROSIS INTERNATIONAL
  • 1997-01. Gonadal hormone substitutes: Effects on the cardiovascular system in OSTEOPOROSIS INTERNATIONAL
  • 1994-02. Effects of Estrogen Treatment on Arterial Wall Structure and Function in DRUGS
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