Unresolved Public Health Issues Related To Ht And Cancer View Homepage


Ontology type: schema:MonetaryGrant     


Grant Info

YEARS

1979-2012

FUNDING AMOUNT

18189634 USD

ABSTRACT

DESCRIPTION (provided by applicant): This is a resubmission of a competing renewal application requesting support for a Program Project currently in its 27th year of continuous funding. At the recommendation of the Program's External Advisory committee, the theme of this renewal application was narrowed from the previous broad theme of "latrogenic Causes of Cancer" to a more narrow theme of "Unresolved Public Health Issues Related to HT and Cancer." The Program has a rich history of research on exogenous hormones including hormone therapy (HT). Data generated from the Program have had major influences on pharmaceutical formulations, prescribing practices, and chemoprevention strategies regarding exogenous hormone especially HT use. The scientific program of the current application consists of four projects focused around this theme supported by four core resources. The projects include: (1) a study of HT and ovarian cancer emphasizing possible risk differences in formulations and histologic subtypes;(2) a study of HT and non-Hodgkin's lymphomas (NHL), again with an emphasis on possible risk differences by histologic subtypes;(3) a study to determine which women who use HT develop adverse changes in mammographic densities and whether these are the women, in turn, who will develop breast cancer;and (4) a statistical study of the impact of different sources of measurement error in studies of HT and cancer. As a major emphasis of the Program will be to evaluate the potential risk modifying effects of a series of genes contributing to absorption, transport and metabolism of HT, this latter project also deals with statistical issues related to identification and analysis of reconstructed haplotypes. Core resources include a Scientific Leadership and Administrative Core (Core A) for overseeing scientific direction and conducting the administrative activities required by this Program;the Cancer Surveillance Core (Core B), which provides case identification, including especially rapid case ascertainment for the projects;a Genotyping Core (Core C), for genotyping a large series of candidate genes involved in HT absorption, transport and metabolism and selected additional genes;and a Control Identification Core (Core D), which provides neighborhood control identification for two of the proposed projects. More... »

URL

http://projectreporter.nih.gov/project_info_description.cfm?aid=7661562

Related SciGraph Publications

  • 2019-12. Shared heritability and functional enrichment across six solid cancers in NATURE COMMUNICATIONS
  • 2019-03-23. Joint exposure to smoking, excessive weight, and physical inactivity and survival of ovarian cancer patients, evidence from the Ovarian Cancer Association Consortium in CANCER CAUSES & CONTROL
  • 2018-12. Growth factor genes and change in mammographic density after stopping combined hormone therapy in the California Teachers Study in BMC CANCER
  • 2018-12. Body mass index at age 18 years and recent body mass index in relation to risk of breast cancer overall and ER/PR/HER2-defined subtypes in white women and African-American women: a pooled analysis in BREAST CANCER RESEARCH
  • 2017-12. Reproductive factors and the risk of triple-negative breast cancer in white women and African-American women: a pooled analysis in BREAST CANCER RESEARCH
  • 2017-04. Use of common analgesic medications and ovarian cancer survival: results from a pooled analysis in the Ovarian Cancer Association Consortium in BRITISH JOURNAL OF CANCER
  • 2017-02. Enrichment of putative PAX8 target genes at serous epithelial ovarian cancer susceptibility loci in BRITISH JOURNAL OF CANCER
  • 2016-09-07. Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast–ovarian cancer susceptibility locus in NATURE COMMUNICATIONS
  • 2016-07. Assessing the genetic architecture of epithelial ovarian cancer histological subtypes in HUMAN GENETICS
  • 2016-06. Recreational physical inactivity and mortality in women with invasive epithelial ovarian cancer: evidence from the Ovarian Cancer Association Consortium in BRITISH JOURNAL OF CANCER
  • 2015-09. Obesity and survival among women with ovarian cancer: results from the Ovarian Cancer Association Consortium in BRITISH JOURNAL OF CANCER
  • 2014-12. Hormone metabolism pathway genes and mammographic density change after quitting estrogen and progestin combined hormone therapy in the California Teachers Study in BREAST CANCER RESEARCH
  • 2014-05. Genome-wide association study of subtype-specific epithelial ovarian cancer risk alleles using pooled DNA in HUMAN GENETICS
  • 2014-02. Estimating risks for variants of unknown significance according to their predicted pathogenicity classes with application to BRCA1 in BREAST CANCER RESEARCH AND TREATMENT
  • 2013-12. Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer in NATURE COMMUNICATIONS
  • 2013-12. Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31 in NATURE COMMUNICATIONS
  • 2013-05. Cigarette smoking and risk of ovarian cancer: a pooled analysis of 21 case–control studies in CANCER CAUSES & CONTROL
  • 2013-02. Household endotoxin levels and the risk of non-Hodgkin lymphoma in CANCER CAUSES & CONTROL
  • 2011-12. Spatial-temporal analysis of non-Hodgkin lymphoma in the NCI-SEER NHL case-control study in ENVIRONMENTAL HEALTH
  • 2011-04. The association of polymorphisms in hormone metabolism pathway genes, menopausal hormone therapy, and breast cancer risk: a nested case-control study in the California Teachers Study cohort in BREAST CANCER RESEARCH
  • 2011-04. Diagnostic radiography and adult acute myeloid leukaemia: an interview and medical chart review study in BRITISH JOURNAL OF CANCER
  • 2010-10. A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24 in NATURE GENETICS
  • 2009-07. Complementary and alternative therapies among very long-term breast cancer survivors in BREAST CANCER RESEARCH AND TREATMENT
  • 2009-03. Tagging single-nucleotide polymorphisms in candidate oncogenes and susceptibility to ovarian cancer in BRITISH JOURNAL OF CANCER
  • 2009-03. Urinary tract infections and reduced risk of bladder cancer in Los Angeles in BRITISH JOURNAL OF CANCER
  • 2009-01. Validating genetic risk associations for ovarian cancer through the international Ovarian Cancer Association Consortium in BRITISH JOURNAL OF CANCER
  • 2008-08. Family cancer history and risk of brain tumors in children: results of the SEARCH international brain tumor study in CANCER CAUSES & CONTROL
  • 2008-05. Low-dose medical radiation exposure and breast cancer risk in women under age 50 years overall and by estrogen and progesterone receptor status: results from a case–control and a case–case comparison in BREAST CANCER RESEARCH AND TREATMENT
  • 2008-03. Alcohol intake and breast cancer risk among young women in BREAST CANCER RESEARCH AND TREATMENT
  • 2008-03. A promoter polymorphism in the CASP8 gene is not associated with cancer risk in NATURE GENETICS
  • 2008-02. Evaluation of unclassified variants in the breast cancer susceptibility genes BRCA1 and BRCA2using five methods: results from a population-based study of young breast cancer patients in BREAST CANCER RESEARCH
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  • 2007-10. The effect of atopy, childhood crowding, and other immune-related factors on non-Hodgkin lymphoma risk in CANCER CAUSES & CONTROL
  • 2007-08. A common genetic risk factor for colorectal and prostate cancer in NATURE GENETICS
  • 2006-08. Hormone-related risk factors for breast cancer in women under age 50 years by estrogen and progesterone receptor status: results from a case–control and a case–case comparison in BREAST CANCER RESEARCH
  • 2005-11. Etiologic Clues from the Similarity of Histology-specific Trends in Esophageal and Lung Cancers in CANCER CAUSES & CONTROL
  • 2005-04. Beauty product-related exposures and childhood brain tumors in seven countries: results from the SEARCH International Brain Tumor Study in JOURNAL OF NEURO-ONCOLOGY
  • 2005-03. Influence of exercise activity on quality of life in long-term breast cancer survivors in QUALITY OF LIFE RESEARCH
  • 2004-06. Exercise activity, body size and premenopausal breast cancer survival in BRITISH JOURNAL OF CANCER
  • 2003-11. Risk factors for anal cancer: results of a population-based case–control study in CANCER CAUSES & CONTROL
  • 2003-07. Phenobarbital use and bladder cancer risk in EUROPEAN JOURNAL OF EPIDEMIOLOGY
  • 2002-10. Medical radiation, family history of cancer, and benign breast disease in relation to breast cancer risk in young women, USA in CANCER CAUSES & CONTROL
  • 2002-03. Galactose-1-phosphate uridyl transferase (GALT) genotype and phenotype, galactose consumption, and the risk of borderline and invasive ovarian cancer (United States) in CANCER CAUSES & CONTROL
  • 2001-11. Parental occupations and childhood brain tumors: results of an international case–control study in CANCER CAUSES & CONTROL
  • 2001-04. Risk Factors for Penile Cancer: Results of a Population-based Case–Control study in Los Angeles County (United States) in CANCER CAUSES & CONTROL
  • 2000-11. Preliminary Assessment of Cognitive Function in Breast Cancer Patients Treated with Tamoxifen in BREAST CANCER RESEARCH AND TREATMENT
  • 2000-04. Non-steroidal anti-inflammatory drugs and bladder cancer prevention in BRITISH JOURNAL OF CANCER
  • 2000-03. Eye problems in breast cancer patients treated with tamoxifen in BREAST CANCER RESEARCH AND TREATMENT
  • 2000-02. Descriptive epidemiology of thyroid cancer in Los Angeles County, 1972–1995 in CANCER CAUSES & CONTROL
  • 1999-10. Regular use of analgesics is a risk factor for renal cell carcinoma in BRITISH JOURNAL OF CANCER
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