Cold Spring Harbor Laboratory Cancer Research Center View Homepage


Ontology type: schema:MonetaryGrant     


Grant Info

YEARS

1977-2023

FUNDING AMOUNT

84805864 USD

ABSTRACT

PROJECT SUMMARY - OVERALL The overall goal of this Program is to understand how basic cellular processes are altered and co-opted by cancer cells to promote tumor initiation and progression, and to apply this knowledge towards development of new therapeutic approaches. During the past 46 years, the strong underlying basic science foundation of the Program Project has allowed members to identify vulnerabilities in cancer and develop novel and highly specific therapeutic strategies. This Program continues to take a multi-pronged approach grounded in basic cancer research to identify and disrupt the molecular dependencies underlying cancer. Within this Program, there are five highly integrated Projects (Chromosome Inheritance; Regulation of Pre- mRNA Splicing in Tumorigenesis; Long Non-Coding RNAs and Cancer; Transcriptional Coactivators and Enhancers In Human Cancer; Tumor Suppressor and Tumor Maintenance Genes) and four innovative Cores that are using cutting edge technologies to study the molecular mechanisms of cancer biology. To achieve the Program's goals, these studies will exploit novel animal models of human cancers, pioneering functional genomics technologies, therapeutic antisense oligonucleotide strategies against otherwise undruggable targets, and cutting-edge methods in biochemistry, cell biology and molecular biology. The researchers will interrogate the basis of many of the most devastating types of tumors, including leukemias, breast, pancreatic, and highly aggressive liver cancers. All of this work is supported by four Cores that provide access to technologies, services, and expertise that all combine to enhance productivity and promote interactions. The interactive and collaborative nature of this Program guides each of these Projects beyond their singular potential. Research in all five Projects touches on overlapping themes and benefits from the expertise of the other Program members. Together, this Program is making significant progress towards its goal of identifying novel therapeutic targets that will substantially impact cancer treatment. More... »

URL

http://projectreporter.nih.gov/project_info_description.cfm?aid=9417196

Related SciGraph Publications

  • 2018-12. MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity in NATURE COMMUNICATIONS
  • 2018-04. Quantitative self-assembly prediction yields targeted nanomedicines in NATURE MATERIALS
  • 2018-02. Asparagine bioavailability governs metastasis in a model of breast cancer in NATURE
  • 2017-04. Prediction of potent shRNAs with a sequential classification algorithm in NATURE BIOTECHNOLOGY
  • 2016. Meier-Gorlin Syndrome in THE INITIATION OF DNA REPLICATION IN EUKARYOTES
  • 2015-12. The spliceosome, a potential Achilles heel of MYC-driven tumors in GENOME MEDICINE
  • 2015-12. The histone chaperone CAF-1 safeguards somatic cell identity in NATURE
  • 2015-09. Cancer: Mutant p53 and chromatin regulation in NATURE
  • 2015-05. Cooperative loss of RAS feedback regulation drives myeloid leukemogenesis in NATURE GENETICS
  • 2015-04. A model of breast cancer heterogeneity reveals vascular mimicry as a driver of metastasis in NATURE
  • 2015-04. Inducible in vivo genome editing with CRISPR-Cas9 in NATURE BIOTECHNOLOGY
  • 2015-04. A common functional consequence of tumor-derived mutations within c-MYC in ONCOGENE
  • 2014-12. In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system in NATURE
  • 2014-10. In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer in NATURE MEDICINE
  • 2014-06. PTEN action in leukaemia dictated by the tissue microenvironment in NATURE
  • 2014-02. Splicing factor SRSF6 promotes hyperplasia of sensitized skin in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2014-01. Stable RNA interference rules for silencing in NATURE CELL BIOLOGY
  • 2013-12. Suppression of eukaryotic initiation factor 4E prevents chemotherapy-induced alopecia in BMC PHARMACOLOGY AND TOXICOLOGY
  • 2012-07. A tumour suppressor network relying on the polyamine–hypusine axis in NATURE
  • 2012-03. An alternative mode of microRNA target recognition in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2012-02-02. A pipeline for the generation of shRNA transgenic mice in NATURE PROTOCOLS
  • 2012-02. The microcosmos of cancer in NATURE
  • 2012-02. RNA therapeutics: beyond RNA interference and antisense oligonucleotides in NATURE REVIEWS DRUG DISCOVERY
  • 2012-02. The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2012. The Origin Recognition Complex: A Biochemical and Structural View in THE EUKARYOTIC REPLISOME: A GUIDE TO PROTEIN STRUCTURE AND FUNCTION
  • 2012. Antisense-Mediated Exon Inclusion in EXON SKIPPING
  • 2011-11. miR-34 miRNAs provide a barrier for somatic cell reprogramming in NATURE CELL BIOLOGY
  • 2011-09. Targeted resequencing of a genomic region influencing tameness and aggression reveals multiple signals of positive selection in HEREDITY
  • 2011-03-20. Silencing of microRNA families by seed-targeting tiny LNAs in NATURE GENETICS
  • 2011-03. AXL receptor kinase is a mediator of YAP-dependent oncogenic functions in hepatocellular carcinoma in ONCOGENE
  • 2011-03. FAS and NF-κB signalling modulate dependence of lung cancers on mutant EGFR in NATURE
  • 2011-01. Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi in NATURE BIOTECHNOLOGY
  • 2011-01. Direct visualization of the co-transcriptional assembly of a nuclear body by noncoding RNAs in NATURE CELL BIOLOGY
  • 2010-07. Non-germline genetically engineered mouse models for translational cancer research in NATURE REVIEWS CANCER
  • 2010-06. A dicer-independent miRNA biogenesis pathway that requires Ago catalysis in NATURE
  • 2010-03. SF2/ASF autoregulation involves multiple layers of post-transcriptional and translational control in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2010-02. Ancient animal microRNAs and the evolution of tissue identity in NATURE
  • 2009-10-08. Gal4 turnover and transcription activation in NATURE
  • 2009-06. Hybrid selection of discrete genomic intervals on custom-designed microarrays for massively parallel sequencing in NATURE PROTOCOLS
  • 2008-11. IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-κB as well as cell survival and oncogenesis in NATURE CELL BIOLOGY
  • 2008-10-16. Transcriptional Control and the Ubiquitin–Proteasome System in THE UBIQUITIN SYSTEM IN HEALTH AND DISEASE
  • 2008-08. Alta-Cyclic: a self-optimizing base caller for next-generation sequencing in NATURE METHODS
  • 2008-05-22. Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes in NATURE
  • 2008-05-08. Genome analysis of the platypus reveals unique signatures of evolution in NATURE
  • 2008-03. A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2007-11. microRNAs join the p53 network — another piece in the tumour-suppression puzzle in NATURE REVIEWS CANCER
  • 2007-10. p400 function is required for the adenovirus E1A-mediated suppression of EGFR and tumour cell killing in ONCOGENE
  • 2007-07. Tissue-specific and reversible RNA interference in transgenic mice in NATURE GENETICS
  • 2007-06-28. A microRNA component of the p53 tumour suppressor network in NATURE
  • 2007-03. The gene encoding the splicing factor SF2/ASF is a proto-oncogene in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/2206", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/2206", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/2211", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "type": "DefinedTerm"
          }
        ], 
        "amount": {
          "currency": "USD", 
          "type": "MonetaryAmount", 
          "value": "84805864"
        }, 
        "description": "PROJECT SUMMARY - OVERALL The overall goal of this Program is to understand how basic cellular processes are altered and co-opted by cancer cells to promote tumor initiation and progression, and to apply this knowledge towards development of new therapeutic approaches. During the past 46 years, the strong underlying basic science foundation of the Program Project has allowed members to identify vulnerabilities in cancer and develop novel and highly specific therapeutic strategies. This Program continues to take a multi-pronged approach grounded in basic cancer research to identify and disrupt the molecular dependencies underlying cancer. Within this Program, there are five highly integrated Projects (Chromosome Inheritance; Regulation of Pre- mRNA Splicing in Tumorigenesis; Long Non-Coding RNAs and Cancer; Transcriptional Coactivators and Enhancers In Human Cancer; Tumor Suppressor and Tumor Maintenance Genes) and four innovative Cores that are using cutting edge technologies to study the molecular mechanisms of cancer biology. To achieve the Program's goals, these studies will exploit novel animal models of human cancers, pioneering functional genomics technologies, therapeutic antisense oligonucleotide strategies against otherwise undruggable targets, and cutting-edge methods in biochemistry, cell biology and molecular biology. The researchers will interrogate the basis of many of the most devastating types of tumors, including leukemias, breast, pancreatic, and highly aggressive liver cancers. All of this work is supported by four Cores that provide access to technologies, services, and expertise that all combine to enhance productivity and promote interactions. The interactive and collaborative nature of this Program guides each of these Projects beyond their singular potential. Research in all five Projects touches on overlapping themes and benefits from the expertise of the other Program members. Together, this Program is making significant progress towards its goal of identifying novel therapeutic targets that will substantially impact cancer treatment.", 
        "endDate": "2023-01-31T00:00:00Z", 
        "funder": {
          "id": "https://www.grid.ac/institutes/grid.48336.3a", 
          "type": "Organization"
        }, 
        "id": "sg:grant.2435368", 
        "identifier": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "2435368"
            ]
          }, 
          {
            "name": "nih_id", 
            "type": "PropertyValue", 
            "value": [
              "P01CA013106"
            ]
          }
        ], 
        "inLanguage": [
          "en"
        ], 
        "keywords": [
          "study", 
          "interaction", 
          "molecular dependencies", 
          "biochemistry", 
          "program", 
          "cutting-edge methods", 
          "long non-coding RNAs", 
          "functional genomics technologies", 
          "aggressive liver cancer", 
          "therapeutic antisense oligonucleotide strategies", 
          "pancreatic", 
          "overall goal", 
          "devastating type", 
          "leukemias", 
          "tumor", 
          "tumor suppressor", 
          "singular potentials", 
          "years", 
          "chromosome inheritance", 
          "breast", 
          "molecular biology", 
          "research", 
          "expertise", 
          "development", 
          "knowledge", 
          "program project", 
          "human cancers", 
          "cancer biology", 
          "cancer", 
          "basis", 
          "services", 
          "basic cellular processes", 
          "innovative core", 
          "tumorigenesis", 
          "undruggable targets", 
          "benefits", 
          "specific therapeutic strategies", 
          "therapeutic target", 
          "researchers", 
          "goal", 
          "core", 
          "enhancer", 
          "program goals", 
          "Tumor Maintenance Genes", 
          "Projects", 
          "tumor initiation", 
          "work", 
          "productivity", 
          "technology", 
          "access", 
          "new therapeutic approaches", 
          "basic cancer research", 
          "strong underlying basic science foundation", 
          "Cold Spring Harbor Laboratory Cancer Research Center", 
          "cancer cells", 
          "significant progress", 
          "novel", 
          "project", 
          "progression", 
          "cancer treatment", 
          "members", 
          "cell biology", 
          "themes", 
          "regulation", 
          "vulnerability", 
          "approach", 
          "novel animal model", 
          "edge technologies", 
          "PROJECT SUMMARY - OVERALL", 
          "Pre- mRNA Splicing", 
          "transcriptional coactivator", 
          "multi", 
          "other Program members", 
          "collaborative nature", 
          "molecular mechanisms"
        ], 
        "name": "Cold Spring Harbor Laboratory Cancer Research Center", 
        "recipient": [
          {
            "id": "https://www.grid.ac/institutes/grid.225279.9", 
            "type": "Organization"
          }, 
          {
            "affiliation": {
              "id": "https://www.grid.ac/institutes/grid.225279.9", 
              "name": "COLD SPRING HARBOR LABORATORY", 
              "type": "Organization"
            }, 
            "familyName": "STILLMAN", 
            "givenName": "BRUCE W.", 
            "id": "sg:person.01030306604.51", 
            "type": "Person"
          }, 
          {
            "member": "sg:person.01030306604.51", 
            "roleName": "PI", 
            "type": "Role"
          }
        ], 
        "sameAs": [
          "https://app.dimensions.ai/details/grant/grant.2435368"
        ], 
        "sdDataset": "grants", 
        "sdDatePublished": "2019-03-07T12:11", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com.uberresearch.data.processor/core_data/20181219_192338/projects/base/nih_projects_4.xml.gz", 
        "startDate": "1977-01-01T00:00:00Z", 
        "type": "MonetaryGrant", 
        "url": "http://projectreporter.nih.gov/project_info_description.cfm?aid=9417196"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/grant.2435368'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/grant.2435368'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/grant.2435368'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/grant.2435368'


     

    This table displays all metadata directly associated to this object as RDF triples.

    122 TRIPLES      19 PREDICATES      97 URIs      88 LITERALS      5 BLANK NODES

    Subject Predicate Object
    1 sg:grant.2435368 schema:about anzsrc-for:2206
    2 anzsrc-for:2211
    3 schema:amount Ne6a2512c15e2468885f2e78bc18f37e2
    4 schema:description PROJECT SUMMARY - OVERALL The overall goal of this Program is to understand how basic cellular processes are altered and co-opted by cancer cells to promote tumor initiation and progression, and to apply this knowledge towards development of new therapeutic approaches. During the past 46 years, the strong underlying basic science foundation of the Program Project has allowed members to identify vulnerabilities in cancer and develop novel and highly specific therapeutic strategies. This Program continues to take a multi-pronged approach grounded in basic cancer research to identify and disrupt the molecular dependencies underlying cancer. Within this Program, there are five highly integrated Projects (Chromosome Inheritance; Regulation of Pre- mRNA Splicing in Tumorigenesis; Long Non-Coding RNAs and Cancer; Transcriptional Coactivators and Enhancers In Human Cancer; Tumor Suppressor and Tumor Maintenance Genes) and four innovative Cores that are using cutting edge technologies to study the molecular mechanisms of cancer biology. To achieve the Program's goals, these studies will exploit novel animal models of human cancers, pioneering functional genomics technologies, therapeutic antisense oligonucleotide strategies against otherwise undruggable targets, and cutting-edge methods in biochemistry, cell biology and molecular biology. The researchers will interrogate the basis of many of the most devastating types of tumors, including leukemias, breast, pancreatic, and highly aggressive liver cancers. All of this work is supported by four Cores that provide access to technologies, services, and expertise that all combine to enhance productivity and promote interactions. The interactive and collaborative nature of this Program guides each of these Projects beyond their singular potential. Research in all five Projects touches on overlapping themes and benefits from the expertise of the other Program members. Together, this Program is making significant progress towards its goal of identifying novel therapeutic targets that will substantially impact cancer treatment.
    5 schema:endDate 2023-01-31T00:00:00Z
    6 schema:funder https://www.grid.ac/institutes/grid.48336.3a
    7 schema:identifier N76a31f068d824fd3a6157f192044058a
    8 Nf974159b74934a748071f1d14bde2447
    9 schema:inLanguage en
    10 schema:keywords Cold Spring Harbor Laboratory Cancer Research Center
    11 PROJECT SUMMARY - OVERALL
    12 Pre- mRNA Splicing
    13 Projects
    14 Tumor Maintenance Genes
    15 access
    16 aggressive liver cancer
    17 approach
    18 basic cancer research
    19 basic cellular processes
    20 basis
    21 benefits
    22 biochemistry
    23 breast
    24 cancer
    25 cancer biology
    26 cancer cells
    27 cancer treatment
    28 cell biology
    29 chromosome inheritance
    30 collaborative nature
    31 core
    32 cutting-edge methods
    33 devastating type
    34 development
    35 edge technologies
    36 enhancer
    37 expertise
    38 functional genomics technologies
    39 goal
    40 human cancers
    41 innovative core
    42 interaction
    43 knowledge
    44 leukemias
    45 long non-coding RNAs
    46 members
    47 molecular biology
    48 molecular dependencies
    49 molecular mechanisms
    50 multi
    51 new therapeutic approaches
    52 novel
    53 novel animal model
    54 other Program members
    55 overall goal
    56 pancreatic
    57 productivity
    58 program
    59 program goals
    60 program project
    61 progression
    62 project
    63 regulation
    64 research
    65 researchers
    66 services
    67 significant progress
    68 singular potentials
    69 specific therapeutic strategies
    70 strong underlying basic science foundation
    71 study
    72 technology
    73 themes
    74 therapeutic antisense oligonucleotide strategies
    75 therapeutic target
    76 transcriptional coactivator
    77 tumor
    78 tumor initiation
    79 tumor suppressor
    80 tumorigenesis
    81 undruggable targets
    82 vulnerability
    83 work
    84 years
    85 schema:name Cold Spring Harbor Laboratory Cancer Research Center
    86 schema:recipient N3f9d09f5a5e14b60a6518b3f276f296e
    87 sg:person.01030306604.51
    88 https://www.grid.ac/institutes/grid.225279.9
    89 schema:sameAs https://app.dimensions.ai/details/grant/grant.2435368
    90 schema:sdDatePublished 2019-03-07T12:11
    91 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    92 schema:sdPublisher N076afa19145e4c29b50acf84f164da3f
    93 schema:startDate 1977-01-01T00:00:00Z
    94 schema:url http://projectreporter.nih.gov/project_info_description.cfm?aid=9417196
    95 sgo:license sg:explorer/license/
    96 sgo:sdDataset grants
    97 rdf:type schema:MonetaryGrant
    98 N076afa19145e4c29b50acf84f164da3f schema:name Springer Nature - SN SciGraph project
    99 rdf:type schema:Organization
    100 N3f9d09f5a5e14b60a6518b3f276f296e schema:member sg:person.01030306604.51
    101 schema:roleName PI
    102 rdf:type schema:Role
    103 N76a31f068d824fd3a6157f192044058a schema:name nih_id
    104 schema:value P01CA013106
    105 rdf:type schema:PropertyValue
    106 Ne6a2512c15e2468885f2e78bc18f37e2 schema:currency USD
    107 schema:value 84805864
    108 rdf:type schema:MonetaryAmount
    109 Nf974159b74934a748071f1d14bde2447 schema:name dimensions_id
    110 schema:value 2435368
    111 rdf:type schema:PropertyValue
    112 anzsrc-for:2206 schema:inDefinedTermSet anzsrc-for:
    113 rdf:type schema:DefinedTerm
    114 anzsrc-for:2211 schema:inDefinedTermSet anzsrc-for:
    115 rdf:type schema:DefinedTerm
    116 sg:person.01030306604.51 schema:affiliation https://www.grid.ac/institutes/grid.225279.9
    117 schema:familyName STILLMAN
    118 schema:givenName BRUCE W.
    119 rdf:type schema:Person
    120 https://www.grid.ac/institutes/grid.225279.9 schema:name COLD SPRING HARBOR LABORATORY
    121 rdf:type schema:Organization
    122 https://www.grid.ac/institutes/grid.48336.3a schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...