Genetic Analysis of the TNF Pathway in Psoriasis View Homepage


Ontology type: schema:MonetaryGrant     


Grant Info

YEARS

2010-2016

FUNDING AMOUNT

599050 USD

ABSTRACT

DESCRIPTION (provided by applicant): This proposal describes a 5 year training program for the development of an academic career in the field of psoriasis genetics. The candidate completed his medical studies at Harvard, performed a year of clinical research training at the NIH, and recently graduated from a dermatology residency at UCSF. Over the past year, as a UCSF junior faculty member, the candidate has contributed to the discovery of several psoriasis genes through his establishment of a large psoriasis patient database. Through the proposed training program, the candidate will expand upon his scientific skills to become an independent investigator in human genetics. He will accomplish this through coursework, participation in seminars and conferences, national presentations, and engagement in a mentored research project. Dr. Pui-Yan Kwok will mentor the candidate's scientific development. Dr. Kwok is a recognized leader in the field of genetics and genomics. Dr. Kwok serves as the Henry Bachrach Distinguished Professor at UCSF and is a founding member of the International HapMap Consortium. His record of mentoring postdoctoral fellows and graduate students is superb. To enhance the candidate's training, an advisory committee of highly-regarded senior scientists will provide scientific and career advice. The advisory committee will consist of two geneticists (Anne Bowcock, PhD., Joint Director for Human Genetics at Washington University, and Lindsey Criswell, MD, MPH, Professor of Medicine and Rheumatology at UCSF) and an immunologist (Averil Ma, MD, Professor of Medicine and Gastroenterology at UCSF). Of note, Dr. Criswell and Dr. Ma's own research interests are integrally tied to the candidate's proposed research plan; thus, the candidate will receive closer-than-usual feedback through a unique team science approach. Research will focus on the role of TNF pathway gene variants in psoriasis. Recent results from a large genome wide association study in psoriasis demonstrate that two genes in the TNF pathway, TNFAIP3 and TNIP1, are major risk factors for the development of psoriasis. The research project will perform fine mapping of these two genes to identify causal variants, and additionally examine other genes in this pathway for genetic association. High throughput genotyping, DNA sequencing, and copy number assays will be employed. The aggregate data will provide the first detailed picture of TNF pathway genes in psoriasis. The proposed training program draws on the combined resources of the UCSF Institute for Human Genetics, UCSF Department of Dermatology, and UCSF Psoriasis Center. This will provide an ideal setting for the candidate's maturation into an independent investigator. More... »

URL

http://projectreporter.nih.gov/project_info_description.cfm?aid=8728557

Related SciGraph Publications

  • 2016-04. A Common Variant in CLDN14 is Associated with Primary Biliary Cirrhosis and Bone Mineral Density in SCIENTIFIC REPORTS
  • 2015-12. Genome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility in NATURE COMMUNICATIONS
  • 2015-04. The cumulative effects of known susceptibility variants to predict primary biliary cirrhosis risk in GENES & IMMUNITY
  • 2015-03. Meta-analysis of the TNFAIP3 region in psoriasis reveals a risk haplotype that is distinct from other autoimmune diseases in GENES & IMMUNITY
  • 2014-12. Diminished humoral responses against and reduced gene expression levels of human endogenous retrovirus-K (HERV-K) in psoriasis in JOURNAL OF TRANSLATIONAL MEDICINE
  • 2014-07. No Evidence for Integrated Viral DNA in the Genome Sequence of Cutaneous Squamous Cell Carcinoma in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2014-03. Genetic Epidemiology of Psoriasis in CURRENT DERMATOLOGY REPORTS
  • 2013-12. A pilot study demonstrating a non-invasive method for the measurement of protein turnover in skin disorders: application to psoriasis in CLINICAL AND TRANSLATIONAL MEDICINE
  • 2013-03. Association of Cardiovascular and Metabolic Disease Genes with Psoriasis in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2012-12. Detection of identity by descent using next-generation whole genome sequencing data in BMC BIOINFORMATICS
  • 2012-12. Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity in NATURE GENETICS
  • 2012-07. Protective Effect of Human Endogenous Retrovirus K dUTPase Variants on Psoriasis Susceptibility in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2012-03. A Subset of Methylated CpG Sites Differentiate Psoriatic from Normal Skin in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2011-12. Association analysis identifies ZNF750 regulatory variants in psoriasis in BMC MEDICAL GENETICS
  • 2011-05. Meta-Analysis Confirms the LCE3C_LCE3B Deletion as a Risk Factor for Psoriasis in Several Ethnic Groups and Finds Interaction with HLA-Cw6 in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2011-04. Sequencing of TNFAIP3 and association of variants with multiple autoimmune diseases in GENES & IMMUNITY
  • 2010-12. Carriers of Rare Missense Variants in IFIH1 Are Protected from Psoriasis in JOURNAL OF INVESTIGATIVE DERMATOLOGY
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