Influence of Prior Walking on Postprandial Metabolism and Endothelial Function in South Asian vs White European Women. View Homepage


Ontology type: schema:MedicalStudy     


Clinical Trial Info

YEARS

2017-2018

ABSTRACT

The present study will investigate the effect of prior walking on postprandial metabolism and endothelial function in healthy South Asian and White European women. Participants will complete two, 2-day trials in a random, crossover design separated by at least 3 weeks to control for the menstrual cycle phase. On day 1, participants will either rest or complete a 60 minute walk at 60% maximal oxygen uptake. On day 2, participants will arrive at 08:00 having fasted overnight and a baseline venous blood sample and endothelial function measurement will be taken. Participants will consume a high-fat breakfast and lunch and 12 subsequent venous blood samples will be taken throughout the day at standardised intervals to measure a variety of coronary heart disease risk markers. A second endothelial function measurement will be completed 2 hours after the breakfast. Blood pressure will be measured every hour. It is expected that the South Asian participants will have impaired metabolism and endothelial function compared to their European counterparts but the bout of exercise performed on day 1 will mitigate these responses. Detailed Description South Asian individuals have a higher-than-average risk of coronary heart disease. The reasons for this are unclear, but physical inactivity and/or poor responsiveness to exercise may play a role. Previous research from our laboratory has shown that coronary heart disease risk markers in the postprandial period are elevated in South Asian men, but acute exercise was equally, if not more, effective for reducing these risk markers in South Asian than White European men. However, the effect of acute exercise on coronary heart disease risk markers has not been examined in South Asian women. Therefore, the purpose of the present study is to compare the effect of acute exercise on endothelial function and coronary heart disease risk markers in women of South Asian versus White European descent. On visit 1, participants will attend the laboratory to undergo preliminary assessments and to be familiarised with the laboratory environment and study procedures. Specifically, health status, habitual physical activity, dietary habits and anthropometric data (height, weight, waist and hip circumference, body fat) will be collected. Two preliminary exercise tests will be performed as follows: 1) submaximal-incremental treadmill walking test and 2) incremental treadmill running test to exhaustion to measure maximal oxygen uptake. On visit 2, participants will undergo a magnetic resonance imaging (MRI) scan to quantify regional body composition comprising abdominal subcutaneous adipose tissue, visceral adipose tissue, liver fat percentage, thigh intramuscular adipose tissue and thigh muscle volume. On visits 3-6 participants will complete two, 2-day trials in a random, crossover design seperated by at least 3 weeks to control for the menstrual cycle phase. On day 1 of both trials, participants will arrive fasted at 08:00 and a baseline blood sample, blood pressure and endothelial function measurement will be taken. Participants will consume a standardised high fat breakfast at 09:00 and lunch at 13:00. At 15:30 the participants will walk for 60 minutes at 60% maximal oxygen uptake and complete a second endothelial function measurement at 16:45. Participants will leave the laboratory with a standardised evening meal to consume before 22:00. The control trial will be the same, except no exercise will be performed. On day 2, participants will arrive at 08:00 having fasted overnight for 10h (except plain water). A cannula will be inserted into the antecubital vein for collection of venous blood samples. Blood pressure will be measured at 08:00 (0h) and again at hourly intervals throughout the day. Endothelial function will measured at 08:15 (0.25h) and again at 3h. At 0h, a fasting blood sample will be collected. Subsequent venous blood samples will be collected at 1.5, 1.75, 2, 3, 4, 5, 5.5, 5.75, 6, 7, 8 and 9h. Participants will consume a standardised high fat breakfast at 1h and a standardised high fat lunch at 5h. The meals consist of 57% fat, 32% carbohydrate and 11% protein. The meals provide 14.3 kcal per kg of body mass. Participants will rest in the laboratory throughout day 2 of both the exercise and control trials. More... »

URL

https://clinicaltrials.gov/show/NCT03712501

Related SciGraph Publications

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/3053", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }
    ], 
    "description": "The present study will investigate the effect of prior walking on postprandial metabolism and endothelial function in healthy South Asian and White European women. Participants will complete two, 2-day trials in a random, crossover design separated by at least 3 weeks to control for the menstrual cycle phase. On day 1, participants will either rest or complete a 60 minute walk at 60% maximal oxygen uptake. On day 2, participants will arrive at 08:00 having fasted overnight and a baseline venous blood sample and endothelial function measurement will be taken. Participants will consume a high-fat breakfast and lunch and 12 subsequent venous blood samples will be taken throughout the day at standardised intervals to measure a variety of coronary heart disease risk markers. A second endothelial function measurement will be completed 2 hours after the breakfast. Blood pressure will be measured every hour. It is expected that the South Asian participants will have impaired metabolism and endothelial function compared to their European counterparts but the bout of exercise performed on day 1 will mitigate these responses.\n\nDetailed Description\nSouth Asian individuals have a higher-than-average risk of coronary heart disease. The reasons for this are unclear, but physical inactivity and/or poor responsiveness to exercise may play a role. Previous research from our laboratory has shown that coronary heart disease risk markers in the postprandial period are elevated in South Asian men, but acute exercise was equally, if not more, effective for reducing these risk markers in South Asian than White European men. However, the effect of acute exercise on coronary heart disease risk markers has not been examined in South Asian women. Therefore, the purpose of the present study is to compare the effect of acute exercise on endothelial function and coronary heart disease risk markers in women of South Asian versus White European descent. On visit 1, participants will attend the laboratory to undergo preliminary assessments and to be familiarised with the laboratory environment and study procedures. Specifically, health status, habitual physical activity, dietary habits and anthropometric data (height, weight, waist and hip circumference, body fat) will be collected. Two preliminary exercise tests will be performed as follows: 1) submaximal-incremental treadmill walking test and 2) incremental treadmill running test to exhaustion to measure maximal oxygen uptake. On visit 2, participants will undergo a magnetic resonance imaging (MRI) scan to quantify regional body composition comprising abdominal subcutaneous adipose tissue, visceral adipose tissue, liver fat percentage, thigh intramuscular adipose tissue and thigh muscle volume. On visits 3-6 participants will complete two, 2-day trials in a random, crossover design seperated by at least 3 weeks to control for the menstrual cycle phase. On day 1 of both trials, participants will arrive fasted at 08:00 and a baseline blood sample, blood pressure and endothelial function measurement will be taken. Participants will consume a standardised high fat breakfast at 09:00 and lunch at 13:00. At 15:30 the participants will walk for 60 minutes at 60% maximal oxygen uptake and complete a second endothelial function measurement at 16:45. Participants will leave the laboratory with a standardised evening meal to consume before 22:00. The control trial will be the same, except no exercise will be performed. On day 2, participants will arrive at 08:00 having fasted overnight for 10h (except plain water). A cannula will be inserted into the antecubital vein for collection of venous blood samples. Blood pressure will be measured at 08:00 (0h) and again at hourly intervals throughout the day. Endothelial function will measured at 08:15 (0.25h) and again at 3h. At 0h, a fasting blood sample will be collected. Subsequent venous blood samples will be collected at 1.5, 1.75, 2, 3, 4, 5, 5.5, 5.75, 6, 7, 8 and 9h. Participants will consume a standardised high fat breakfast at 1h and a standardised high fat lunch at 5h. The meals consist of 57% fat, 32% carbohydrate and 11% protein. The meals provide 14.3 kcal per kg of body mass. Participants will rest in the laboratory throughout day 2 of both the exercise and control trials.", 
    "endDate": "2018-12-01T00:00:00Z", 
    "id": "sg:clinicaltrial.NCT03712501", 
    "keywords": [
      "metabolism", 
      "endothelial function", 
      "South", 
      "woman", 
      "present study", 
      "trial", 
      "Cross-Over Study", 
      "control", 
      "menstrual cycle phase", 
      "rest", 
      "oxygen uptake", 
      "blood sample", 
      "high fat", 
      "lunch", 
      "interval", 
      "coronary heart disease risk", 
      "breakfast", 
      "blood pressure", 
      "South Asians", 
      "European counterpart", 
      "bout", 
      "exercise", 
      "mitigate", 
      "individual", 
      "average risk", 
      "Coronary Disease", 
      "physical inactivity", 
      "responsiveness", 
      "previous research", 
      "laboratory", 
      "period", 
      "acute exercise", 
      "risk marker", 
      "men", 
      "European descent", 
      "preliminary assessment", 
      "laboratory environment", 
      "study procedure", 
      "health status", 
      "habitual physical activity", 
      "Food Habit", 
      "anthropometric data", 
      "height", 
      "weight", 
      "waist", 
      "hip circumference", 
      "adipose tissue", 
      "Exercise Test", 
      "treadmill", 
      "exhaustion", 
      "Magnetic Resonance Imaging", 
      "body composition", 
      "Subcutaneous Fat", 
      "Intra-Abdominal Fat", 
      "liver fat", 
      "muscle", 
      "visit", 
      "evening", 
      "control trial", 
      "plain", 
      "catheter", 
      "vein", 
      "collection", 
      "fasting blood sample", 
      "meal", 
      "carbohydrate", 
      "protein", 
      "kcal", 
      "body mass"
    ], 
    "name": "Influence of Prior Walking on Postprandial Metabolism and Endothelial Function in South Asian vs White European Women.", 
    "sameAs": [
      "https://app.dimensions.ai/details/clinical_trial/NCT03712501"
    ], 
    "sdDataset": "clinical_trials", 
    "sdDatePublished": "2019-03-07T15:28", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "file:///pack/app/us_ct_data_00028.json", 
    "sponsor": [
      {
        "id": "https://www.grid.ac/institutes/grid.269014.8", 
        "type": "Organization"
      }, 
      {
        "id": "https://www.grid.ac/institutes/grid.6571.5", 
        "type": "Organization"
      }
    ], 
    "startDate": "2017-10-01T00:00:00Z", 
    "subjectOf": [
      {
        "id": "https://doi.org/10.1249/mss.0b013e3182853ecf", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043967539"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00421-015-3269-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045948594", 
          "https://doi.org/10.1007/s00421-015-3269-7"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "type": "MedicalStudy", 
    "url": "https://clinicaltrials.gov/show/NCT03712501"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/clinicaltrial.NCT03712501'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/clinicaltrial.NCT03712501'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/clinicaltrial.NCT03712501'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/clinicaltrial.NCT03712501'


 

This table displays all metadata directly associated to this object as RDF triples.

97 TRIPLES      16 PREDICATES      87 URIs      78 LITERALS      1 BLANK NODES

Subject Predicate Object
1 sg:clinicaltrial.NCT03712501 schema:about anzsrc-for:3053
2 schema:description The present study will investigate the effect of prior walking on postprandial metabolism and endothelial function in healthy South Asian and White European women. Participants will complete two, 2-day trials in a random, crossover design separated by at least 3 weeks to control for the menstrual cycle phase. On day 1, participants will either rest or complete a 60 minute walk at 60% maximal oxygen uptake. On day 2, participants will arrive at 08:00 having fasted overnight and a baseline venous blood sample and endothelial function measurement will be taken. Participants will consume a high-fat breakfast and lunch and 12 subsequent venous blood samples will be taken throughout the day at standardised intervals to measure a variety of coronary heart disease risk markers. A second endothelial function measurement will be completed 2 hours after the breakfast. Blood pressure will be measured every hour. It is expected that the South Asian participants will have impaired metabolism and endothelial function compared to their European counterparts but the bout of exercise performed on day 1 will mitigate these responses. Detailed Description South Asian individuals have a higher-than-average risk of coronary heart disease. The reasons for this are unclear, but physical inactivity and/or poor responsiveness to exercise may play a role. Previous research from our laboratory has shown that coronary heart disease risk markers in the postprandial period are elevated in South Asian men, but acute exercise was equally, if not more, effective for reducing these risk markers in South Asian than White European men. However, the effect of acute exercise on coronary heart disease risk markers has not been examined in South Asian women. Therefore, the purpose of the present study is to compare the effect of acute exercise on endothelial function and coronary heart disease risk markers in women of South Asian versus White European descent. On visit 1, participants will attend the laboratory to undergo preliminary assessments and to be familiarised with the laboratory environment and study procedures. Specifically, health status, habitual physical activity, dietary habits and anthropometric data (height, weight, waist and hip circumference, body fat) will be collected. Two preliminary exercise tests will be performed as follows: 1) submaximal-incremental treadmill walking test and 2) incremental treadmill running test to exhaustion to measure maximal oxygen uptake. On visit 2, participants will undergo a magnetic resonance imaging (MRI) scan to quantify regional body composition comprising abdominal subcutaneous adipose tissue, visceral adipose tissue, liver fat percentage, thigh intramuscular adipose tissue and thigh muscle volume. On visits 3-6 participants will complete two, 2-day trials in a random, crossover design seperated by at least 3 weeks to control for the menstrual cycle phase. On day 1 of both trials, participants will arrive fasted at 08:00 and a baseline blood sample, blood pressure and endothelial function measurement will be taken. Participants will consume a standardised high fat breakfast at 09:00 and lunch at 13:00. At 15:30 the participants will walk for 60 minutes at 60% maximal oxygen uptake and complete a second endothelial function measurement at 16:45. Participants will leave the laboratory with a standardised evening meal to consume before 22:00. The control trial will be the same, except no exercise will be performed. On day 2, participants will arrive at 08:00 having fasted overnight for 10h (except plain water). A cannula will be inserted into the antecubital vein for collection of venous blood samples. Blood pressure will be measured at 08:00 (0h) and again at hourly intervals throughout the day. Endothelial function will measured at 08:15 (0.25h) and again at 3h. At 0h, a fasting blood sample will be collected. Subsequent venous blood samples will be collected at 1.5, 1.75, 2, 3, 4, 5, 5.5, 5.75, 6, 7, 8 and 9h. Participants will consume a standardised high fat breakfast at 1h and a standardised high fat lunch at 5h. The meals consist of 57% fat, 32% carbohydrate and 11% protein. The meals provide 14.3 kcal per kg of body mass. Participants will rest in the laboratory throughout day 2 of both the exercise and control trials.
3 schema:endDate 2018-12-01T00:00:00Z
4 schema:keywords Coronary Disease
5 Cross-Over Study
6 European counterpart
7 European descent
8 Exercise Test
9 Food Habit
10 Intra-Abdominal Fat
11 Magnetic Resonance Imaging
12 South
13 South Asians
14 Subcutaneous Fat
15 acute exercise
16 adipose tissue
17 anthropometric data
18 average risk
19 blood pressure
20 blood sample
21 body composition
22 body mass
23 bout
24 breakfast
25 carbohydrate
26 catheter
27 collection
28 control
29 control trial
30 coronary heart disease risk
31 endothelial function
32 evening
33 exercise
34 exhaustion
35 fasting blood sample
36 habitual physical activity
37 health status
38 height
39 high fat
40 hip circumference
41 individual
42 interval
43 kcal
44 laboratory
45 laboratory environment
46 liver fat
47 lunch
48 meal
49 men
50 menstrual cycle phase
51 metabolism
52 mitigate
53 muscle
54 oxygen uptake
55 period
56 physical inactivity
57 plain
58 preliminary assessment
59 present study
60 previous research
61 protein
62 responsiveness
63 rest
64 risk marker
65 study procedure
66 treadmill
67 trial
68 vein
69 visit
70 waist
71 weight
72 woman
73 schema:name Influence of Prior Walking on Postprandial Metabolism and Endothelial Function in South Asian vs White European Women.
74 schema:sameAs https://app.dimensions.ai/details/clinical_trial/NCT03712501
75 schema:sdDatePublished 2019-03-07T15:28
76 schema:sdLicense https://scigraph.springernature.com/explorer/license/
77 schema:sdPublisher N3502a07cf7f640778b4c8e6b5ee8b1cb
78 schema:sponsor https://www.grid.ac/institutes/grid.269014.8
79 https://www.grid.ac/institutes/grid.6571.5
80 schema:startDate 2017-10-01T00:00:00Z
81 schema:subjectOf sg:pub.10.1007/s00421-015-3269-7
82 https://doi.org/10.1249/mss.0b013e3182853ecf
83 schema:url https://clinicaltrials.gov/show/NCT03712501
84 sgo:license sg:explorer/license/
85 sgo:sdDataset clinical_trials
86 rdf:type schema:MedicalStudy
87 N3502a07cf7f640778b4c8e6b5ee8b1cb schema:name Springer Nature - SN SciGraph project
88 rdf:type schema:Organization
89 anzsrc-for:3053 schema:inDefinedTermSet anzsrc-for:
90 rdf:type schema:DefinedTerm
91 sg:pub.10.1007/s00421-015-3269-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045948594
92 https://doi.org/10.1007/s00421-015-3269-7
93 rdf:type schema:CreativeWork
94 https://doi.org/10.1249/mss.0b013e3182853ecf schema:sameAs https://app.dimensions.ai/details/publication/pub.1043967539
95 rdf:type schema:CreativeWork
96 https://www.grid.ac/institutes/grid.269014.8 schema:Organization
97 https://www.grid.ac/institutes/grid.6571.5 schema:Organization
 




Preview window. Press ESC to close (or click here)


...