Developing and Testing a Culturally-tailored Personalized Nutrition Intervention in South Asian Women at Risk of Gestational Diabetes View Homepage


Ontology type: schema:MedicalStudy     


Clinical Trial Info

YEARS

2018-2022

ABSTRACT

This study will assess the feasibility of delivering, and the effectiveness of a culturally-tailored personalized nutrition program to reduce gestational dysglycemia in women of South Asian ancestry living in Ontario. The trial will be deemed feasible if the investigators can recruit the desired sample within 2 years, retain >80% of participants and achieve at least 2 of 4 agreed-upon dietary goals in >80% of participants. The intervention will be deemed acceptable if >80% of participants would recommend the program to a friend. The primary clinical outcome of the trial is gestational dysglycemia, and the secondary outcomes are GDM, infant birthweight and adiposity, and obstetrical complications. The results of the feasibility, acceptability, and clinical outcome assessments of this study will be used to plan a full-scale study to assess whether a culturally-tailored personalized nutrition program can reduce GDM in this population. Detailed Description South Asians, people whose ancestors originate from India, Pakistan, Bangladesh, or Sri Lanka, are the largest and fastest growing non-white ethnic group in Canada, and are at particularly high risk of type 2 diabetes (T2DM) and premature cardiovascular disease (CVD). Gestational diabetes (GDM), a type of diabetes that occurs during pregnancy, affects 3% of pregnancies, but 12% of pregnancies in women of South Asian descent. Untreated, gestational diabetes can increase the risk of macrosomia, and maternal and offspring risks of obesity and type 2 diabetes. In our South Asian prospective birth cohort (START), we have shown that, compared to white Caucasian women, pregnant South Asian women: i) have an increased risk of elevated blood glucose and GDM; and ii) are more likely to give birth to infants of lower weight but greater adiposity. Lower birth weight and more adipose infants are more likely to become insulin-resistant during adolescence and develop T2DM as adults. Therefore, interventions that optimize glycemia in pregnancy may reduce the risk of GDM as well as lower the risk of T2DM and atherosclerosis in mothers and their offspring in adult life. Diet is an important modifiable risk factor for hyperglycemia and GDM, but there is uncertainty about the optimal method of delivering an intervention in a South Asian population. Barriers to healthy eating during pregnancy for South Asian women include: i) changing long-held cultural diet practices; ii) difficulty adapting standard dietary advice to personal health beliefs; iii) navigating food choices at family gatherings; and iv) accommodating meal needs of others in the household. The study will advance the understanding of effective and acceptable dietary modifications to reduce gestational dysglycemia (as measured by the area under the curve of glucose) in pregnant South Asian women, a high-risk segment of the Canadian population. The investigators will evaluate the feasibility of delivering a culturally-tailored, personalized nutrition intervention program to high-risk South Asian women in Peel region, Ontario. The intervention is guided by the team's previous research in South Asian communities and pregnant women and grounded in qualitative work with women and their health care providers. The objectives of this pilot trial among pregnant women of South Asian descent are to: 1. Evaluate the feasibility of delivering a culturally-tailored nutrition intervention program to pregnant South Asian women, living in Peel region, Ontario. 2. Evaluate the effectiveness of a culturally-tailored nutrition program to improve gestational dysglycemia (as measured by the incremental area-under-the-curve [AUC] of glucose, the primary clinical outcome) and reduce gestational diabetes (secondary, exploratory outcome) 3. Evaluate the effectiveness of a culturally-tailored nutrition program on infant anthropometrics (e.g. birth weight and length, and skinfold thickness; secondary, exploratory outcomes) The results of the feasibility, acceptability, and clinical outcome assessments of our study will be used to plan a future, full-scale study to assess whether a culturally-tailored personalized nutrition program can reduce GDM in this population. More... »

URL

https://clinicaltrials.gov/show/NCT03607799

Related SciGraph Publications

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/3136", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/3177", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/3158", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }
    ], 
    "description": "This study will assess the feasibility of delivering, and the effectiveness of a culturally-tailored personalized nutrition program to reduce gestational dysglycemia in women of South Asian ancestry living in Ontario. The trial will be deemed feasible if the investigators can recruit the desired sample within 2 years, retain >80% of participants and achieve at least 2 of 4 agreed-upon dietary goals in >80% of participants. The intervention will be deemed acceptable if >80% of participants would recommend the program to a friend. The primary clinical outcome of the trial is gestational dysglycemia, and the secondary outcomes are GDM, infant birthweight and adiposity, and obstetrical complications. The results of the feasibility, acceptability, and clinical outcome assessments of this study will be used to plan a full-scale study to assess whether a culturally-tailored personalized nutrition program can reduce GDM in this population.\n\nDetailed Description\nSouth Asians, people whose ancestors originate from India, Pakistan, Bangladesh, or Sri Lanka, are the largest and fastest growing non-white ethnic group in Canada, and are at particularly high risk of type 2 diabetes (T2DM) and premature cardiovascular disease (CVD). Gestational diabetes (GDM), a type of diabetes that occurs during pregnancy, affects 3% of pregnancies, but 12% of pregnancies in women of South Asian descent. Untreated, gestational diabetes can increase the risk of macrosomia, and maternal and offspring risks of obesity and type 2 diabetes. In our South Asian prospective birth cohort (START), we have shown that, compared to white Caucasian women, pregnant South Asian women: i) have an increased risk of elevated blood glucose and GDM; and ii) are more likely to give birth to infants of lower weight but greater adiposity. Lower birth weight and more adipose infants are more likely to become insulin-resistant during adolescence and develop T2DM as adults. Therefore, interventions that optimize glycemia in pregnancy may reduce the risk of GDM as well as lower the risk of T2DM and atherosclerosis in mothers and their offspring in adult life. Diet is an important modifiable risk factor for hyperglycemia and GDM, but there is uncertainty about the optimal method of delivering an intervention in a South Asian population. Barriers to healthy eating during pregnancy for South Asian women include: i) changing long-held cultural diet practices; ii) difficulty adapting standard dietary advice to personal health beliefs; iii) navigating food choices at family gatherings; and iv) accommodating meal needs of others in the household. The study will advance the understanding of effective and acceptable dietary modifications to reduce gestational dysglycemia (as measured by the area under the curve of glucose) in pregnant South Asian women, a high-risk segment of the Canadian population. The investigators will evaluate the feasibility of delivering a culturally-tailored, personalized nutrition intervention program to high-risk South Asian women in Peel region, Ontario. The intervention is guided by the team's previous research in South Asian communities and pregnant women and grounded in qualitative work with women and their health care providers. The objectives of this pilot trial among pregnant women of South Asian descent are to: 1. Evaluate the feasibility of delivering a culturally-tailored nutrition intervention program to pregnant South Asian women, living in Peel region, Ontario. 2. Evaluate the effectiveness of a culturally-tailored nutrition program to improve gestational dysglycemia (as measured by the incremental area-under-the-curve [AUC] of glucose, the primary clinical outcome) and reduce gestational diabetes (secondary, exploratory outcome) 3. Evaluate the effectiveness of a culturally-tailored nutrition program on infant anthropometrics (e.g. birth weight and length, and skinfold thickness; secondary, exploratory outcomes) The results of the feasibility, acceptability, and clinical outcome assessments of our study will be used to plan a future, full-scale study to assess whether a culturally-tailored personalized nutrition program can reduce GDM in this population.", 
    "endDate": "2022-12-01T00:00:00Z", 
    "id": "sg:clinicaltrial.NCT03607799", 
    "keywords": [
      "nutrition intervention", 
      "South Asians", 
      "risk", 
      "Gestational Diabetes", 
      "feasibility", 
      "effectiveness", 
      "nutrition program", 
      "woman", 
      "Ontario", 
      "trial", 
      "sample", 
      "intervention", 
      "friend", 
      "primary clinical outcome", 
      "Secondary outcome", 
      "GDM", 
      "birthweight", 
      "adiposity", 
      "obstetrical complication", 
      "acceptability", 
      "Outcome Assessment", 
      "full-scale study", 
      "population", 
      "ancestor", 
      "India", 
      "Pakistan", 
      "Bangladesh", 
      "Sri Lanka", 
      "ethnic group", 
      "Canada", 
      "high risk", 
      "type 2 diabetes", 
      "T2DM", 
      "cardiovascular disease", 
      "diabetes", 
      "pregnancy", 
      "macrosomia", 
      "offspring", 
      "obesity", 
      "birth cohort", 
      "start", 
      "Caucasian woman", 
      "increased risk", 
      "elevated blood glucose", 
      "Parturition", 
      "infant", 
      "low weight", 
      "birth weight", 
      "adipose", 
      "insulin", 
      "Adolescent", 
      "adult", 
      "glycemia", 
      "atherosclerosis", 
      "mother", 
      "adult life", 
      "diet", 
      "risk factor", 
      "hyperglycemia", 
      "uncertainty", 
      "optimal method", 
      "Asian population", 
      "barrier", 
      "practice", 
      "dietary advice", 
      "personal health", 
      "food choice", 
      "gathering", 
      "accommodating", 
      "Family Characteristic", 
      "modification", 
      "curve", 
      "glucose", 
      "Canadian population", 
      "peel", 
      "team", 
      "previous research", 
      "South Asian community", 
      "pregnant woman", 
      "qualitative work", 
      "Health Personnel", 
      "pilot trial", 
      "Evaluate", 
      "area under the curve", 
      "exploratory", 
      "anthropometric", 
      "skinfold thickness"
    ], 
    "name": "Developing and Testing a Culturally-tailored Personalized Nutrition Intervention in South Asian Women at Risk of Gestational Diabetes", 
    "sameAs": [
      "https://app.dimensions.ai/details/clinical_trial/NCT03607799"
    ], 
    "sdDataset": "clinical_trials", 
    "sdDatePublished": "2019-03-07T15:27", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "file:///pack/app/us_ct_data_00027.json", 
    "sponsor": [
      {
        "id": "https://www.grid.ac/institutes/grid.25073.33", 
        "type": "Organization"
      }, 
      {
        "id": "https://www.grid.ac/institutes/grid.415102.3", 
        "type": "Organization"
      }
    ], 
    "startDate": "2018-09-01T00:00:00Z", 
    "subjectOf": [
      {
        "id": "https://doi.org/10.3945/jn.115.223461", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003149073"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/gco.0b013e328359f0f4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003885365"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1079/bjn19970114", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005312186"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.e2088", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006136125"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jcjd.2013.01.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006722887"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jand.2012.04.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008094364"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00592-014-0660-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009699920", 
          "https://doi.org/10.1007/s00592-014-0660-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0277-9536(99)00314-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010737058"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-0528.2010.02801.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013819644"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ijo.2015.171", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015095459", 
          "https://doi.org/10.1038/ijo.2015.171"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2458-13-79", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017102074", 
          "https://doi.org/10.1186/1471-2458-13-79"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa0707943", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017211150"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(09)60731-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018648938"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diacare.25.10.1862", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020345164"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pmed.1001036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020429407"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s2213-8587(15)00255-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025141393"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-012-2689-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026662495", 
          "https://doi.org/10.1007/s00125-012-2689-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-012-2689-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026662495", 
          "https://doi.org/10.1007/s00125-012-2689-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/dc15-0511", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028076223"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/14651858.cd006674.pub3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028753995"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2196/resprot.2621", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030210204"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s2213-8587(15)00227-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030639749"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.e5605", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031322706"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0156851", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033575033"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3945/ajcn.2010.29363", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033848077"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jamacardio.2016.1035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035005762"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/dc06-1816", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035065697"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0088495", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037160480"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/dc07-1596", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038186759"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/jaha.113.000490", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038530962"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.9778/cmajo.20130064", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039176674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1479-828x.2010.01268.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039214264"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12884-016-1205-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039494803", 
          "https://doi.org/10.1186/s12884-016-1205-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12884-016-1205-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039494803", 
          "https://doi.org/10.1186/s12884-016-1205-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.2015.10945", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039609612"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1357633x15595178", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042098065"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/14767058.2012.735996", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042241270"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-0528.2011.03184.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044617869"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/dc15-0360", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044728765"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2393-11-81", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045588343", 
          "https://doi.org/10.1186/1471-2393-11-81"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12916-015-0360-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047783259", 
          "https://doi.org/10.1186/s12916-015-0360-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-0528.2010.02619.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048218568"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1503/cmaj.080012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048924982"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2458-11-936", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051030462", 
          "https://doi.org/10.1186/1471-2458-11-936"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3329/jhpn.v28i3.5548", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053170137"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0182095", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090989421"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.9778/cmajo.20170027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091157787"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "type": "MedicalStudy", 
    "url": "https://clinicaltrials.gov/show/NCT03607799"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/clinicaltrial.NCT03607799'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/clinicaltrial.NCT03607799'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/clinicaltrial.NCT03607799'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/clinicaltrial.NCT03607799'


 

This table displays all metadata directly associated to this object as RDF triples.

257 TRIPLES      16 PREDICATES      150 URIs      96 LITERALS      1 BLANK NODES

Subject Predicate Object
1 sg:clinicaltrial.NCT03607799 schema:about anzsrc-for:3136
2 anzsrc-for:3158
3 anzsrc-for:3177
4 schema:description This study will assess the feasibility of delivering, and the effectiveness of a culturally-tailored personalized nutrition program to reduce gestational dysglycemia in women of South Asian ancestry living in Ontario. The trial will be deemed feasible if the investigators can recruit the desired sample within 2 years, retain >80% of participants and achieve at least 2 of 4 agreed-upon dietary goals in >80% of participants. The intervention will be deemed acceptable if >80% of participants would recommend the program to a friend. The primary clinical outcome of the trial is gestational dysglycemia, and the secondary outcomes are GDM, infant birthweight and adiposity, and obstetrical complications. The results of the feasibility, acceptability, and clinical outcome assessments of this study will be used to plan a full-scale study to assess whether a culturally-tailored personalized nutrition program can reduce GDM in this population. Detailed Description South Asians, people whose ancestors originate from India, Pakistan, Bangladesh, or Sri Lanka, are the largest and fastest growing non-white ethnic group in Canada, and are at particularly high risk of type 2 diabetes (T2DM) and premature cardiovascular disease (CVD). Gestational diabetes (GDM), a type of diabetes that occurs during pregnancy, affects 3% of pregnancies, but 12% of pregnancies in women of South Asian descent. Untreated, gestational diabetes can increase the risk of macrosomia, and maternal and offspring risks of obesity and type 2 diabetes. In our South Asian prospective birth cohort (START), we have shown that, compared to white Caucasian women, pregnant South Asian women: i) have an increased risk of elevated blood glucose and GDM; and ii) are more likely to give birth to infants of lower weight but greater adiposity. Lower birth weight and more adipose infants are more likely to become insulin-resistant during adolescence and develop T2DM as adults. Therefore, interventions that optimize glycemia in pregnancy may reduce the risk of GDM as well as lower the risk of T2DM and atherosclerosis in mothers and their offspring in adult life. Diet is an important modifiable risk factor for hyperglycemia and GDM, but there is uncertainty about the optimal method of delivering an intervention in a South Asian population. Barriers to healthy eating during pregnancy for South Asian women include: i) changing long-held cultural diet practices; ii) difficulty adapting standard dietary advice to personal health beliefs; iii) navigating food choices at family gatherings; and iv) accommodating meal needs of others in the household. The study will advance the understanding of effective and acceptable dietary modifications to reduce gestational dysglycemia (as measured by the area under the curve of glucose) in pregnant South Asian women, a high-risk segment of the Canadian population. The investigators will evaluate the feasibility of delivering a culturally-tailored, personalized nutrition intervention program to high-risk South Asian women in Peel region, Ontario. The intervention is guided by the team's previous research in South Asian communities and pregnant women and grounded in qualitative work with women and their health care providers. The objectives of this pilot trial among pregnant women of South Asian descent are to: 1. Evaluate the feasibility of delivering a culturally-tailored nutrition intervention program to pregnant South Asian women, living in Peel region, Ontario. 2. Evaluate the effectiveness of a culturally-tailored nutrition program to improve gestational dysglycemia (as measured by the incremental area-under-the-curve [AUC] of glucose, the primary clinical outcome) and reduce gestational diabetes (secondary, exploratory outcome) 3. Evaluate the effectiveness of a culturally-tailored nutrition program on infant anthropometrics (e.g. birth weight and length, and skinfold thickness; secondary, exploratory outcomes) The results of the feasibility, acceptability, and clinical outcome assessments of our study will be used to plan a future, full-scale study to assess whether a culturally-tailored personalized nutrition program can reduce GDM in this population.
5 schema:endDate 2022-12-01T00:00:00Z
6 schema:keywords Adolescent
7 Asian population
8 Bangladesh
9 Canada
10 Canadian population
11 Caucasian woman
12 Evaluate
13 Family Characteristic
14 GDM
15 Gestational Diabetes
16 Health Personnel
17 India
18 Ontario
19 Outcome Assessment
20 Pakistan
21 Parturition
22 Secondary outcome
23 South Asian community
24 South Asians
25 Sri Lanka
26 T2DM
27 acceptability
28 accommodating
29 adipose
30 adiposity
31 adult
32 adult life
33 ancestor
34 anthropometric
35 area under the curve
36 atherosclerosis
37 barrier
38 birth cohort
39 birth weight
40 birthweight
41 cardiovascular disease
42 curve
43 diabetes
44 diet
45 dietary advice
46 effectiveness
47 elevated blood glucose
48 ethnic group
49 exploratory
50 feasibility
51 food choice
52 friend
53 full-scale study
54 gathering
55 glucose
56 glycemia
57 high risk
58 hyperglycemia
59 increased risk
60 infant
61 insulin
62 intervention
63 low weight
64 macrosomia
65 modification
66 mother
67 nutrition intervention
68 nutrition program
69 obesity
70 obstetrical complication
71 offspring
72 optimal method
73 peel
74 personal health
75 pilot trial
76 population
77 practice
78 pregnancy
79 pregnant woman
80 previous research
81 primary clinical outcome
82 qualitative work
83 risk
84 risk factor
85 sample
86 skinfold thickness
87 start
88 team
89 trial
90 type 2 diabetes
91 uncertainty
92 woman
93 schema:name Developing and Testing a Culturally-tailored Personalized Nutrition Intervention in South Asian Women at Risk of Gestational Diabetes
94 schema:sameAs https://app.dimensions.ai/details/clinical_trial/NCT03607799
95 schema:sdDatePublished 2019-03-07T15:27
96 schema:sdLicense https://scigraph.springernature.com/explorer/license/
97 schema:sdPublisher N6ae02552e45e4adc869f5a20083e8600
98 schema:sponsor https://www.grid.ac/institutes/grid.25073.33
99 https://www.grid.ac/institutes/grid.415102.3
100 schema:startDate 2018-09-01T00:00:00Z
101 schema:subjectOf sg:pub.10.1007/s00125-012-2689-8
102 sg:pub.10.1007/s00592-014-0660-5
103 sg:pub.10.1038/ijo.2015.171
104 sg:pub.10.1186/1471-2393-11-81
105 sg:pub.10.1186/1471-2458-11-936
106 sg:pub.10.1186/1471-2458-13-79
107 sg:pub.10.1186/s12884-016-1205-4
108 sg:pub.10.1186/s12916-015-0360-1
109 https://doi.org/10.1001/jama.2015.10945
110 https://doi.org/10.1001/jamacardio.2016.1035
111 https://doi.org/10.1002/14651858.cd006674.pub3
112 https://doi.org/10.1016/j.jand.2012.04.016
113 https://doi.org/10.1016/j.jcjd.2013.01.009
114 https://doi.org/10.1016/s0140-6736(09)60731-5
115 https://doi.org/10.1016/s0277-9536(99)00314-7
116 https://doi.org/10.1016/s2213-8587(15)00227-2
117 https://doi.org/10.1016/s2213-8587(15)00255-7
118 https://doi.org/10.1056/nejmoa0707943
119 https://doi.org/10.1079/bjn19970114
120 https://doi.org/10.1097/gco.0b013e328359f0f4
121 https://doi.org/10.1111/j.1471-0528.2010.02619.x
122 https://doi.org/10.1111/j.1471-0528.2010.02801.x
123 https://doi.org/10.1111/j.1471-0528.2011.03184.x
124 https://doi.org/10.1111/j.1479-828x.2010.01268.x
125 https://doi.org/10.1136/bmj.e2088
126 https://doi.org/10.1136/bmj.e5605
127 https://doi.org/10.1161/jaha.113.000490
128 https://doi.org/10.1177/1357633x15595178
129 https://doi.org/10.1371/journal.pmed.1001036
130 https://doi.org/10.1371/journal.pone.0088495
131 https://doi.org/10.1371/journal.pone.0156851
132 https://doi.org/10.1371/journal.pone.0182095
133 https://doi.org/10.1503/cmaj.080012
134 https://doi.org/10.2196/resprot.2621
135 https://doi.org/10.2337/dc06-1816
136 https://doi.org/10.2337/dc07-1596
137 https://doi.org/10.2337/dc15-0360
138 https://doi.org/10.2337/dc15-0511
139 https://doi.org/10.2337/diacare.25.10.1862
140 https://doi.org/10.3109/14767058.2012.735996
141 https://doi.org/10.3329/jhpn.v28i3.5548
142 https://doi.org/10.3945/ajcn.2010.29363
143 https://doi.org/10.3945/jn.115.223461
144 https://doi.org/10.9778/cmajo.20130064
145 https://doi.org/10.9778/cmajo.20170027
146 schema:url https://clinicaltrials.gov/show/NCT03607799
147 sgo:license sg:explorer/license/
148 sgo:sdDataset clinical_trials
149 rdf:type schema:MedicalStudy
150 N6ae02552e45e4adc869f5a20083e8600 schema:name Springer Nature - SN SciGraph project
151 rdf:type schema:Organization
152 anzsrc-for:3136 schema:inDefinedTermSet anzsrc-for:
153 rdf:type schema:DefinedTerm
154 anzsrc-for:3158 schema:inDefinedTermSet anzsrc-for:
155 rdf:type schema:DefinedTerm
156 anzsrc-for:3177 schema:inDefinedTermSet anzsrc-for:
157 rdf:type schema:DefinedTerm
158 sg:pub.10.1007/s00125-012-2689-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026662495
159 https://doi.org/10.1007/s00125-012-2689-8
160 rdf:type schema:CreativeWork
161 sg:pub.10.1007/s00592-014-0660-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009699920
162 https://doi.org/10.1007/s00592-014-0660-5
163 rdf:type schema:CreativeWork
164 sg:pub.10.1038/ijo.2015.171 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015095459
165 https://doi.org/10.1038/ijo.2015.171
166 rdf:type schema:CreativeWork
167 sg:pub.10.1186/1471-2393-11-81 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045588343
168 https://doi.org/10.1186/1471-2393-11-81
169 rdf:type schema:CreativeWork
170 sg:pub.10.1186/1471-2458-11-936 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051030462
171 https://doi.org/10.1186/1471-2458-11-936
172 rdf:type schema:CreativeWork
173 sg:pub.10.1186/1471-2458-13-79 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017102074
174 https://doi.org/10.1186/1471-2458-13-79
175 rdf:type schema:CreativeWork
176 sg:pub.10.1186/s12884-016-1205-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039494803
177 https://doi.org/10.1186/s12884-016-1205-4
178 rdf:type schema:CreativeWork
179 sg:pub.10.1186/s12916-015-0360-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047783259
180 https://doi.org/10.1186/s12916-015-0360-1
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1001/jama.2015.10945 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039609612
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1001/jamacardio.2016.1035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035005762
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1002/14651858.cd006674.pub3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028753995
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1016/j.jand.2012.04.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008094364
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1016/j.jcjd.2013.01.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006722887
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1016/s0140-6736(09)60731-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018648938
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1016/s0277-9536(99)00314-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010737058
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1016/s2213-8587(15)00227-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030639749
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1016/s2213-8587(15)00255-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025141393
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1056/nejmoa0707943 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017211150
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1079/bjn19970114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005312186
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1097/gco.0b013e328359f0f4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003885365
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1111/j.1471-0528.2010.02619.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1048218568
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1111/j.1471-0528.2010.02801.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1013819644
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1111/j.1471-0528.2011.03184.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044617869
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1111/j.1479-828x.2010.01268.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1039214264
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1136/bmj.e2088 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006136125
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1136/bmj.e5605 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031322706
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1161/jaha.113.000490 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038530962
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1177/1357633x15595178 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042098065
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1371/journal.pmed.1001036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020429407
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1371/journal.pone.0088495 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037160480
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1371/journal.pone.0156851 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033575033
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1371/journal.pone.0182095 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090989421
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1503/cmaj.080012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048924982
231 rdf:type schema:CreativeWork
232 https://doi.org/10.2196/resprot.2621 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030210204
233 rdf:type schema:CreativeWork
234 https://doi.org/10.2337/dc06-1816 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035065697
235 rdf:type schema:CreativeWork
236 https://doi.org/10.2337/dc07-1596 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038186759
237 rdf:type schema:CreativeWork
238 https://doi.org/10.2337/dc15-0360 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044728765
239 rdf:type schema:CreativeWork
240 https://doi.org/10.2337/dc15-0511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028076223
241 rdf:type schema:CreativeWork
242 https://doi.org/10.2337/diacare.25.10.1862 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020345164
243 rdf:type schema:CreativeWork
244 https://doi.org/10.3109/14767058.2012.735996 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042241270
245 rdf:type schema:CreativeWork
246 https://doi.org/10.3329/jhpn.v28i3.5548 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053170137
247 rdf:type schema:CreativeWork
248 https://doi.org/10.3945/ajcn.2010.29363 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033848077
249 rdf:type schema:CreativeWork
250 https://doi.org/10.3945/jn.115.223461 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003149073
251 rdf:type schema:CreativeWork
252 https://doi.org/10.9778/cmajo.20130064 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039176674
253 rdf:type schema:CreativeWork
254 https://doi.org/10.9778/cmajo.20170027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091157787
255 rdf:type schema:CreativeWork
256 https://www.grid.ac/institutes/grid.25073.33 schema:Organization
257 https://www.grid.ac/institutes/grid.415102.3 schema:Organization
 




Preview window. Press ESC to close (or click here)


...