Hyperoxia: An Unrecognized Mechanism for Inducing "Hypoxia-Like" Symptoms View Homepage


Ontology type: schema:MedicalStudy     


Clinical Trial Info

YEARS

2017-2018

ABSTRACT

The investigators will conduct a non-randomized clinical trial to examine the effect of pure oxygen breathing on the brain. The study will compare cerebral blood flow, cortical electrical activity, and cognitive performance in 32 persons during room air (21% oxygen) breathing and pure oxygen (100% oxygen) breathing. Subjects will be used as their own controls. The investigators aim to: 1. Determine whether breathing 100% oxygen changes blood flow through the brain. The investigators will learn whether brain blood flow is increased, decreased or stays the same. 2. Determine if changes that might occur in brain blood flow are also accompanied by changes in the brain's electrical activity (EEG). 3. Learn whether changes in the speed at which the brain processes information (cognitive function) accompany changes in brain blood flow and electrical activity that may be seen. Detailed Description The investigators will conduct a two-arm crossover design clinical trial to compare the effect of room air breathing (21% inspired oxygen) with pure oxygen breathing (100% inspired oxygen) on brain blood flow and cortical electrical activity. The study involves a one-time data collection taking place at University Hospitals Cleveland Medical Center on the Case Western Reserve University campus in Cleveland, OH. The investigators will perform neuroimaging (MRI) with electroencephalographic (EEG) cortical network mapping and cognitive assessments in all participants during room air breathing and again while breathing 100% pure oxygen. Oxygen will be delivered through a non-rebreather mask. Arterial blood partial pressure of oxygen (PaO2) will be measured twice, from arterial blood samples drawn during breathing room air prior to the MRI scan and again after 30 minutes of breathing 100% oxygen immediately following neuroimaging. Thus, the investigators will be able to determine if breathing pure oxygen may temporarily change brain blood flow and breathing, leading to changes in cognitive status such as euphoria or slowed reflexes. Information gained in this study may have direct operational relevance by helping us to understand one potential cause of "Unexplained Physiologic Events" that are reported in some aircraft pilots when flying at high altitude. Information gained could lead to development of new gas mixtures for use by personnel working in low oxygen high altitude environments. More... »

URL

https://clinicaltrials.gov/show/NCT03268590

Related SciGraph Publications

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/3120", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }
    ], 
    "description": "The investigators will conduct a non-randomized clinical trial to examine the effect of pure oxygen breathing on the brain. The study will compare cerebral blood flow, cortical electrical activity, and cognitive performance in 32 persons during room air (21% oxygen) breathing and pure oxygen (100% oxygen) breathing. Subjects will be used as their own controls. The investigators aim to: 1. Determine whether breathing 100% oxygen changes blood flow through the brain. The investigators will learn whether brain blood flow is increased, decreased or stays the same. 2. Determine if changes that might occur in brain blood flow are also accompanied by changes in the brain's electrical activity (EEG). 3. Learn whether changes in the speed at which the brain processes information (cognitive function) accompany changes in brain blood flow and electrical activity that may be seen.\n\nDetailed Description\nThe investigators will conduct a two-arm crossover design clinical trial to compare the effect of room air breathing (21% inspired oxygen) with pure oxygen breathing (100% inspired oxygen) on brain blood flow and cortical electrical activity. The study involves a one-time data collection taking place at University Hospitals Cleveland Medical Center on the Case Western Reserve University campus in Cleveland, OH. The investigators will perform neuroimaging (MRI) with electroencephalographic (EEG) cortical network mapping and cognitive assessments in all participants during room air breathing and again while breathing 100% pure oxygen. Oxygen will be delivered through a non-rebreather mask. Arterial blood partial pressure of oxygen (PaO2) will be measured twice, from arterial blood samples drawn during breathing room air prior to the MRI scan and again after 30 minutes of breathing 100% oxygen immediately following neuroimaging. Thus, the investigators will be able to determine if breathing pure oxygen may temporarily change brain blood flow and breathing, leading to changes in cognitive status such as euphoria or slowed reflexes. Information gained in this study may have direct operational relevance by helping us to understand one potential cause of \"Unexplained Physiologic Events\" that are reported in some aircraft pilots when flying at high altitude. Information gained could lead to development of new gas mixtures for use by personnel working in low oxygen high altitude environments.", 
    "endDate": "2018-05-01T00:00:00Z", 
    "id": "sg:clinicaltrial.NCT03268590", 
    "keywords": [
      "hyperoxia", 
      "unrecognized mechanism", 
      "randomized clinical trial", 
      "pure oxygen", 
      "brain", 
      "cerebral blood flow", 
      "electrical activity", 
      "cognitive performance", 
      "room air", 
      "oxygen", 
      "respiration", 
      "own control", 
      "investigator aim", 
      "Determine", 
      "blood flow", 
      "brain blood flow", 
      "brain electrical activity", 
      "Electroencephalography", 
      "learns", 
      "brain process information", 
      "cognitive function", 
      "design clinical trial", 
      "air breathing", 
      "Data Collection", 
      "Case Western Reserve University", 
      "campus", 
      "Cleveland", 
      "OH", 
      "MRI", 
      "cortical network", 
      "cognitive assessment", 
      "mask", 
      "partial pressure", 
      "PaO2", 
      "arterial blood", 
      "cognitive status", 
      "euphoria", 
      "reflex", 
      "physiologic event", 
      "aircraft", 
      "high altitude", 
      "development", 
      "mixture", 
      "personnel"
    ], 
    "name": "Hyperoxia: An Unrecognized Mechanism for Inducing \"Hypoxia-Like\" Symptoms", 
    "sameAs": [
      "https://app.dimensions.ai/details/clinical_trial/NCT03268590"
    ], 
    "sdDataset": "clinical_trials", 
    "sdDatePublished": "2019-03-07T15:27", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "file:///pack/app/us_ct_data_00025.json", 
    "sponsor": [
      {
        "id": "https://www.grid.ac/institutes/grid.67105.35", 
        "type": "Organization"
      }
    ], 
    "startDate": "2017-10-01T00:00:00Z", 
    "subjectOf": [
      {
        "id": "https://doi.org/10.1093/ilar.50.3.248", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011725179"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11325-009-0305-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031326083", 
          "https://doi.org/10.1007/s11325-009-0305-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1096-8644(199712)104:4<427::aid-ajpa1>3.0.co;2-p", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038603650"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1744-9081-5-43", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040059494", 
          "https://doi.org/10.1186/1744-9081-5-43"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11971", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052910569", 
          "https://doi.org/10.1038/nature11971"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/nbm.3143", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053562674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083148013", 
        "type": "CreativeWork"
      }
    ], 
    "type": "MedicalStudy", 
    "url": "https://clinicaltrials.gov/show/NCT03268590"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/clinicaltrial.NCT03268590'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/clinicaltrial.NCT03268590'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/clinicaltrial.NCT03268590'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/clinicaltrial.NCT03268590'


 

This table displays all metadata directly associated to this object as RDF triples.

86 TRIPLES      16 PREDICATES      66 URIs      53 LITERALS      1 BLANK NODES

Subject Predicate Object
1 sg:clinicaltrial.NCT03268590 schema:about anzsrc-for:3120
2 schema:description The investigators will conduct a non-randomized clinical trial to examine the effect of pure oxygen breathing on the brain. The study will compare cerebral blood flow, cortical electrical activity, and cognitive performance in 32 persons during room air (21% oxygen) breathing and pure oxygen (100% oxygen) breathing. Subjects will be used as their own controls. The investigators aim to: 1. Determine whether breathing 100% oxygen changes blood flow through the brain. The investigators will learn whether brain blood flow is increased, decreased or stays the same. 2. Determine if changes that might occur in brain blood flow are also accompanied by changes in the brain's electrical activity (EEG). 3. Learn whether changes in the speed at which the brain processes information (cognitive function) accompany changes in brain blood flow and electrical activity that may be seen. Detailed Description The investigators will conduct a two-arm crossover design clinical trial to compare the effect of room air breathing (21% inspired oxygen) with pure oxygen breathing (100% inspired oxygen) on brain blood flow and cortical electrical activity. The study involves a one-time data collection taking place at University Hospitals Cleveland Medical Center on the Case Western Reserve University campus in Cleveland, OH. The investigators will perform neuroimaging (MRI) with electroencephalographic (EEG) cortical network mapping and cognitive assessments in all participants during room air breathing and again while breathing 100% pure oxygen. Oxygen will be delivered through a non-rebreather mask. Arterial blood partial pressure of oxygen (PaO2) will be measured twice, from arterial blood samples drawn during breathing room air prior to the MRI scan and again after 30 minutes of breathing 100% oxygen immediately following neuroimaging. Thus, the investigators will be able to determine if breathing pure oxygen may temporarily change brain blood flow and breathing, leading to changes in cognitive status such as euphoria or slowed reflexes. Information gained in this study may have direct operational relevance by helping us to understand one potential cause of "Unexplained Physiologic Events" that are reported in some aircraft pilots when flying at high altitude. Information gained could lead to development of new gas mixtures for use by personnel working in low oxygen high altitude environments.
3 schema:endDate 2018-05-01T00:00:00Z
4 schema:keywords Case Western Reserve University
5 Cleveland
6 Data Collection
7 Determine
8 Electroencephalography
9 MRI
10 OH
11 PaO2
12 air breathing
13 aircraft
14 arterial blood
15 blood flow
16 brain
17 brain blood flow
18 brain electrical activity
19 brain process information
20 campus
21 cerebral blood flow
22 cognitive assessment
23 cognitive function
24 cognitive performance
25 cognitive status
26 cortical network
27 design clinical trial
28 development
29 electrical activity
30 euphoria
31 high altitude
32 hyperoxia
33 investigator aim
34 learns
35 mask
36 mixture
37 own control
38 oxygen
39 partial pressure
40 personnel
41 physiologic event
42 pure oxygen
43 randomized clinical trial
44 reflex
45 respiration
46 room air
47 unrecognized mechanism
48 schema:name Hyperoxia: An Unrecognized Mechanism for Inducing "Hypoxia-Like" Symptoms
49 schema:sameAs https://app.dimensions.ai/details/clinical_trial/NCT03268590
50 schema:sdDatePublished 2019-03-07T15:27
51 schema:sdLicense https://scigraph.springernature.com/explorer/license/
52 schema:sdPublisher N4463fc4a888e41d8a289a7df0eaed436
53 schema:sponsor https://www.grid.ac/institutes/grid.67105.35
54 schema:startDate 2017-10-01T00:00:00Z
55 schema:subjectOf sg:pub.10.1007/s11325-009-0305-z
56 sg:pub.10.1038/nature11971
57 sg:pub.10.1186/1744-9081-5-43
58 https://app.dimensions.ai/details/publication/pub.1083148013
59 https://doi.org/10.1002/(sici)1096-8644(199712)104:4<427::aid-ajpa1>3.0.co;2-p
60 https://doi.org/10.1002/nbm.3143
61 https://doi.org/10.1093/ilar.50.3.248
62 schema:url https://clinicaltrials.gov/show/NCT03268590
63 sgo:license sg:explorer/license/
64 sgo:sdDataset clinical_trials
65 rdf:type schema:MedicalStudy
66 N4463fc4a888e41d8a289a7df0eaed436 schema:name Springer Nature - SN SciGraph project
67 rdf:type schema:Organization
68 anzsrc-for:3120 schema:inDefinedTermSet anzsrc-for:
69 rdf:type schema:DefinedTerm
70 sg:pub.10.1007/s11325-009-0305-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1031326083
71 https://doi.org/10.1007/s11325-009-0305-z
72 rdf:type schema:CreativeWork
73 sg:pub.10.1038/nature11971 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052910569
74 https://doi.org/10.1038/nature11971
75 rdf:type schema:CreativeWork
76 sg:pub.10.1186/1744-9081-5-43 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040059494
77 https://doi.org/10.1186/1744-9081-5-43
78 rdf:type schema:CreativeWork
79 https://app.dimensions.ai/details/publication/pub.1083148013 schema:CreativeWork
80 https://doi.org/10.1002/(sici)1096-8644(199712)104:4<427::aid-ajpa1>3.0.co;2-p schema:sameAs https://app.dimensions.ai/details/publication/pub.1038603650
81 rdf:type schema:CreativeWork
82 https://doi.org/10.1002/nbm.3143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053562674
83 rdf:type schema:CreativeWork
84 https://doi.org/10.1093/ilar.50.3.248 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011725179
85 rdf:type schema:CreativeWork
86 https://www.grid.ac/institutes/grid.67105.35 schema:Organization
 




Preview window. Press ESC to close (or click here)


...