Diagnostic of Iron Deficiency by Means of Non Invasive Measurement of Zink Protoporphyrin IX View Homepage


Ontology type: schema:MedicalStudy     


Clinical Trial Info

YEARS

2017-2018

ABSTRACT

ZnPP is being build in the case of a functional iron deficiency. Zinc instead of iron is implemented into protoporphyrin IX. This ZincProtoporphyrin (ZnPP) can be detected non invasively. Non invasive and invasive optical measurement of ZnPP will be compared. Additionally ZnPP measurements will be compared to other iron deficiency parameters for validation by the investigators. Detailed Description Zinc-protoporphyrin (ZnPP) will be measured by a fluorescence technique. Restricted wave light (407/425 nm) is used to detect ZnPP in the bloodstream non-invasively through the oral mucosa. The spectroscopic measurements are translated into a ZnPP value (mumol/mol heme). The non-invasive measurement of ZnPP is validated and compared to optical measurement of ZnPP in whole blood and high performance liquid chromatography (HPLC) measurement of ZnPP in whole blood. The ZnPP value is compared to other iron-deficiency parameters: Ferritin, Transferrin saturation and soluble Transferrin receptor. More... »

URL

https://clinicaltrials.gov/show/NCT03231865

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/2421", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }
    ], 
    "description": "ZnPP is being build in the case of a functional iron deficiency. Zinc instead of iron is implemented into protoporphyrin IX. This ZincProtoporphyrin (ZnPP) can be detected non invasively. Non invasive and invasive optical measurement of ZnPP will be compared. Additionally ZnPP measurements will be compared to other iron deficiency parameters for validation by the investigators.\n\nDetailed Description\nZinc-protoporphyrin (ZnPP) will be measured by a fluorescence technique. Restricted wave light (407/425 nm) is used to detect ZnPP in the bloodstream non-invasively through the oral mucosa. The spectroscopic measurements are translated into a ZnPP value (mumol/mol heme). The non-invasive measurement of ZnPP is validated and compared to optical measurement of ZnPP in whole blood and high performance liquid chromatography (HPLC) measurement of ZnPP in whole blood. The ZnPP value is compared to other iron-deficiency parameters: Ferritin, Transferrin saturation and soluble Transferrin receptor.", 
    "endDate": "2018-05-01T00:00:00Z", 
    "id": "sg:clinicaltrial.NCT03231865", 
    "keywords": [
      "iron deficiency", 
      "mean", 
      "invasive measurement", 
      "zinc", 
      "iron", 
      "protoporphyrin IX", 
      "optical measurement", 
      "measurement", 
      "validation", 
      "protoporphyrin", 
      "fluorescence technique", 
      "light", 
      "nm", 
      "non-invasively", 
      "Mouth Mucosa", 
      "spectroscopic measurement", 
      "heme", 
      "non-invasive measurement", 
      "blood", 
      "High Pressure Liquid Chromatography", 
      "ferritin", 
      "transferrin saturation", 
      "transferrin receptor"
    ], 
    "name": "Diagnostic of Iron Deficiency by Means of Non Invasive Measurement of Zink Protoporphyrin IX", 
    "sameAs": [
      "https://app.dimensions.ai/details/clinical_trial/NCT03231865"
    ], 
    "sdDataset": "clinical_trials", 
    "sdDatePublished": "2019-03-07T15:27", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "file:///pack/app/us_ct_data_00025.json", 
    "sponsor": [
      {
        "id": "https://www.grid.ac/institutes/grid.412004.3", 
        "type": "Organization"
      }, 
      {
        "id": "https://www.grid.ac/institutes/grid.7400.3", 
        "type": "Organization"
      }
    ], 
    "startDate": "2017-07-01T00:00:00Z", 
    "subjectOf": [
      {
        "id": "sg:pub.10.1038/ncomms10776", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015473637", 
          "https://doi.org/10.1038/ncomms10776"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "type": "MedicalStudy", 
    "url": "https://clinicaltrials.gov/show/NCT03231865"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/clinicaltrial.NCT03231865'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/clinicaltrial.NCT03231865'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/clinicaltrial.NCT03231865'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/clinicaltrial.NCT03231865'


 

This table displays all metadata directly associated to this object as RDF triples.

48 TRIPLES      16 PREDICATES      40 URIs      32 LITERALS      1 BLANK NODES

Subject Predicate Object
1 sg:clinicaltrial.NCT03231865 schema:about anzsrc-for:2421
2 schema:description ZnPP is being build in the case of a functional iron deficiency. Zinc instead of iron is implemented into protoporphyrin IX. This ZincProtoporphyrin (ZnPP) can be detected non invasively. Non invasive and invasive optical measurement of ZnPP will be compared. Additionally ZnPP measurements will be compared to other iron deficiency parameters for validation by the investigators. Detailed Description Zinc-protoporphyrin (ZnPP) will be measured by a fluorescence technique. Restricted wave light (407/425 nm) is used to detect ZnPP in the bloodstream non-invasively through the oral mucosa. The spectroscopic measurements are translated into a ZnPP value (mumol/mol heme). The non-invasive measurement of ZnPP is validated and compared to optical measurement of ZnPP in whole blood and high performance liquid chromatography (HPLC) measurement of ZnPP in whole blood. The ZnPP value is compared to other iron-deficiency parameters: Ferritin, Transferrin saturation and soluble Transferrin receptor.
3 schema:endDate 2018-05-01T00:00:00Z
4 schema:keywords High Pressure Liquid Chromatography
5 Mouth Mucosa
6 blood
7 ferritin
8 fluorescence technique
9 heme
10 invasive measurement
11 iron
12 iron deficiency
13 light
14 mean
15 measurement
16 nm
17 non-invasive measurement
18 non-invasively
19 optical measurement
20 protoporphyrin
21 protoporphyrin IX
22 spectroscopic measurement
23 transferrin receptor
24 transferrin saturation
25 validation
26 zinc
27 schema:name Diagnostic of Iron Deficiency by Means of Non Invasive Measurement of Zink Protoporphyrin IX
28 schema:sameAs https://app.dimensions.ai/details/clinical_trial/NCT03231865
29 schema:sdDatePublished 2019-03-07T15:27
30 schema:sdLicense https://scigraph.springernature.com/explorer/license/
31 schema:sdPublisher Nd2bf50c958f345e18c4561aed4c1e94a
32 schema:sponsor https://www.grid.ac/institutes/grid.412004.3
33 https://www.grid.ac/institutes/grid.7400.3
34 schema:startDate 2017-07-01T00:00:00Z
35 schema:subjectOf sg:pub.10.1038/ncomms10776
36 schema:url https://clinicaltrials.gov/show/NCT03231865
37 sgo:license sg:explorer/license/
38 sgo:sdDataset clinical_trials
39 rdf:type schema:MedicalStudy
40 Nd2bf50c958f345e18c4561aed4c1e94a schema:name Springer Nature - SN SciGraph project
41 rdf:type schema:Organization
42 anzsrc-for:2421 schema:inDefinedTermSet anzsrc-for:
43 rdf:type schema:DefinedTerm
44 sg:pub.10.1038/ncomms10776 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015473637
45 https://doi.org/10.1038/ncomms10776
46 rdf:type schema:CreativeWork
47 https://www.grid.ac/institutes/grid.412004.3 schema:Organization
48 https://www.grid.ac/institutes/grid.7400.3 schema:Organization
 




Preview window. Press ESC to close (or click here)


...