Ontology type: schema:MedicalStudy
2015-2016
ABSTRACTEnvironmental cleanliness As antimicrobial resistance is a major and overall deteriorating public health problem international cooperation is necessary. Continued progress is needed to implement and improve programmes for the prevention and control of antimicrobial resistance and HAIs. Environmental cleanliness might be one of the most important initiatives to reduce HAIs. Hospital surfaces are heavily contaminated with bacteria with the highest numbers on surfaces closest to the patients. Bed rails, nurse call buttons, curtains, towel dispensers, door handles, sinks, floors, clinical information stations, medical devices, stethoscopes, staff toilets etc. Actually, general hospital wards and Intensive Care Units are loaded with an abundance of potential pathogens 8,9,10. Surviving days, weeks or even months in the environment 11. Colonizing patients with bacteria from the hospital environment and getting HAIs or even die. As most ventilator-associated pneumonias (VAPs) are the result of nosocomial microorganisms the environment plays an important role in the acquisition of pathogenic bacteria by contaminating health care workers hands and equipment 12,13. Furthermore, ICUs and wards struggle with colonized patients with ESBL-bacteria from sinks eventually leading to dead or outbreaks of group A streptococcus infections from contaminated curtains 14,15. As key healthcare-associated pathogens have the capacity to persist for weeks to months on hospital surfaces indirect transmission is a serious threat, especially as antimicrobial resistance increases. Hospitalization in a room in which the previous patient had been colonized or infected with nosocomial pathogens (e.g. MRSA, VRE, multidrug-resistant Acinetobacter, Pseudomonas or C. difficile) has been shown to be a risk factor for colonization of infection with the same pathogen for the next patient16. Furthermore, the most important risk factor for hand and glove contamination of healthcare workers with multidrug-resistant bacteria has been demonstrated to be positive environmental cultures 17. To decrease the frequency and level of contamination of environmental surfaces the Centre for Disease Control and Prevention recommends routine disinfection of medical equipment and environmental surfaces to prevent the spread of potential pathogens through the hospital ward or ICU 18. Improved room cleaning has shown to decrease the risk for MRSA, VRE and C. difficile acquisition. Unfortunately, environmental cleaning is frequently inadequate. Less than 50% of hospital room surfaces are adequately cleaned and disinfected even by environmental services personnel. Environmental services personnel have low wages, are under time pressure to clean rooms quickly with high turn-over rates of patients. Novel materials and cleaning technologies have been developed as ultraviolet germicidal irradiation (UVGI) or hydrogen peroxide vapor (HPV). However, both technologies are expensive and can just be used for terminal cleaning and not during routine daily care 16. Self-disinfecting surfaces may overcome these problems. Once applied antimicrobial surfaces will continuously reduce the bioburden of nosocomial pathogens preventing transmission and decrease HAIs. MVX One of these self-disinfecting products is MVX. MVX contains titanium dioxide which by the use of nanotechnology is now available for use in the health sector. Working as a photocatalyticum it generates, in the presence of light, hydroxy radicals and oxygen radicals for at least five years after coating hospital surfaces (durability test TUV Rheinland). Laboratory tests show that MVX is effective in killing bacteria, viruses and fungi (see attachment 1 for summary test results). The positive results reported on the effects of MVX from laboratory evaluations still have to be confirmed in the clinical setting. After getting the CE-marking Gelderse Vallei Hospital in Ede, the Netherlands, will be the first hospital in Europe to study the efficacy of MVX in the Intensive Care Unit (ICU). Detailed Description Introduction and background Background The annual epidemiological report and annual report of the EARS-NET of the European Centre for Disease Prevention and Control (ECDC) describes a continuing deteriorating situation in European countries. Antimicrobial resistance is increasing in Escherichia coli and Klebsiella pneumoniae isolates and surveillance data show high percentages of ESBL-positive isolates. Of particular concern is the increased percentage of Klebsiella pneumoniae and other bacterial groups resistant to carbapanems (last line antibiotics). Furthermore, the percentage of methicillin-resistant Staphylococcus aureus is still high and remains a public health priority On any given day 5.7% of the patients in European hospitals has a healthcare-associated infection (HAI) with a prevalence of at least one HAI of 19.5% for patients admitted to Intensive Care Units. HAIs are accountable for at least 37000 attributable deaths with annual financial losses estimated at €7 billion reflecting 16 million extra days of hospital stay. Each year 4 131 000 patients are affected by approximately 4 544 100 episodes of HAIs. The total number of HAIs in European long-term care facilities (LTCFs) is estimated at 4.2 million per year. 8% to 12% of patients in developed countries is confronted with an adverse event (AE) during their hospital stay leading to (permanent) disability or even dead. As HAIs belong to one of the most important AEs they have a considerable economic impact prolonging hospital length of stay, increase readmission rates and necessitate additional ambulatory care or extra societal costs. The total preventable direct medical costs of AEs in the Netherlands are estimated as 1% of the national health care budget (94.2 billion 2013 - Statistics Netherlands). Environmental cleanliness As antimicrobial resistance is a major and overall deteriorating public health problem international cooperation is necessary. Continued progress is needed to implement and improve programmes for the prevention and control of antimicrobial resistance and HAIs. Environmental cleanliness might be one of the most important initiatives to reduce HAIs. Hospital surfaces are heavily contaminated with bacteria with the highest numbers on surfaces closest to the patients. Bed rails, nurse call buttons, curtains, towel dispensers, door handles, sinks, floors, clinical information stations, medical devices, stethoscopes, staff toilets etc. Actually, general hospital wards and Intensive Care Units are loaded with an abundance of potential pathogens. Surviving days, weeks or even months in the environment. Colonizing patients with bacteria from the hospital environment and getting HAIs or even die. As most ventilator-associated pneumonias (VAPs) are the result of nosocomial microorganisms the environment plays an important role in the acquisition of pathogenic bacteria by contaminating health care workers hands and equipment. Furthermore, ICUs and wards struggle with colonized patients with ESBL-bacteria from sinks eventually leading to dead or outbreaks of group A streptococcus infections from contaminated curtains. As key healthcare-associated pathogens have the capacity to persist for weeks to months on hospital surfaces indirect transmission is a serious threat, especially as antimicrobial resistance increases. Hospitalization in a room in which the previous patient had been colonized or infected with nosocomial pathogens (e.g. MRSA, VRE, multidrug-resistant Acinetobacter, Pseudomonas or C. difficile) has been shown to be a risk factor for colonization of infection with the same pathogen for the next patient. Furthermore, the most important risk factor for hand and glove contamination of healthcare workers with multidrug-resistant bacteria has been demonstrated to be positive environmental cultures. To decrease the frequency and level of contamination of environmental surfaces the Centre for Disease Control and Prevention recommends routine disinfection of medical equipment and environmental surfaces to prevent the spread of potential pathogens through the hospital ward or ICU. Improved room cleaning has shown to decrease the risk for MRSA, VRE and C. difficile acquisition. Unfortunately, environmental cleaning is frequently inadequate. Less than 50% of hospital room surfaces are adequately cleaned and disinfected even by environmental services personnel. Environmental services personnel have low wages, are under time pressure to clean rooms quickly with high turn-over rates of patients. Novel materials and cleaning technologies have been developed as ultraviolet germicidal irradiation (UVGI) or hydrogen peroxide vapor (HPV). However, both technologies are expensive and can just be used for terminal cleaning and not during routine daily care. Self-disinfecting surfaces may overcome these problems. Once applied antimicrobial surfaces will continuously reduce the bioburden of nosocomial pathogens preventing transmission and decrease HAIs. MVX One of these self-disinfecting products is MVX. MVX contains titanium dioxide which by the use of nanotechnology is now available for use in the health sector. Working as a photocatalyticum it generates, in the presence of light, hydroxy radicals and oxygen radicals for at least five years after coating hospital surfaces (durability test TUV Rheinland). Laboratory tests show that MVX is effective in killing bacteria, viruses and fungi. To the best of our knowledge there is just one study who examined the efficacy of titanium dioxide in reducing MRSA contamination in a hospital environment 19. In this cross-sectional observational study two ICU isolation rooms were coated and four beds in a 'Intermediate Care Area' (ICA). However, this study had some serious limitations. As 81% of all the samples (N=698) were taken from untreated surfaces there was a high chance of sampling bias. Especially as just 9% of all the samples were taken from the ICA, containing four of the six coated beds/rooms, against 48% of the ICU and 42% of a general ward. Furthermore, as just 10.6% of the samples were positive (N=74) we can really doubt about the validity of this study by the small sample size. Finally, countries with a low prevalence of MRSA (e.g. the Netherlands) are more interested in the prevalence of Enterobacteriaecae or non-MRSA (potential pathogenic microorganisms) and using a (semi)quantitative method. This makes that the positive results reported on the effects of MVX from laboratory evaluations still have to be confirmed in the clinical setting. After getting the CE-marking Gelderse Vallei Hospital in Ede, the Netherlands, will be the first hospital in Europe to study the efficacy of MVX in the Intensive Care Unit (ICU). More... »
URL
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/3177",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/3114",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"type": "DefinedTerm"
}
],
"description": "Environmental cleanliness As antimicrobial resistance is a major and overall deteriorating public health problem international cooperation is necessary. Continued progress is needed to implement and improve programmes for the prevention and control of antimicrobial resistance and HAIs. Environmental cleanliness might be one of the most important initiatives to reduce HAIs. Hospital surfaces are heavily contaminated with bacteria with the highest numbers on surfaces closest to the patients. Bed rails, nurse call buttons, curtains, towel dispensers, door handles, sinks, floors, clinical information stations, medical devices, stethoscopes, staff toilets etc. Actually, general hospital wards and Intensive Care Units are loaded with an abundance of potential pathogens 8,9,10. Surviving days, weeks or even months in the environment 11. Colonizing patients with bacteria from the hospital environment and getting HAIs or even die. As most ventilator-associated pneumonias (VAPs) are the result of nosocomial microorganisms the environment plays an important role in the acquisition of pathogenic bacteria by contaminating health care workers hands and equipment 12,13. Furthermore, ICUs and wards struggle with colonized patients with ESBL-bacteria from sinks eventually leading to dead or outbreaks of group A streptococcus infections from contaminated curtains 14,15. As key healthcare-associated pathogens have the capacity to persist for weeks to months on hospital surfaces indirect transmission is a serious threat, especially as antimicrobial resistance increases. Hospitalization in a room in which the previous patient had been colonized or infected with nosocomial pathogens (e.g. MRSA, VRE, multidrug-resistant Acinetobacter, Pseudomonas or C. difficile) has been shown to be a risk factor for colonization of infection with the same pathogen for the next patient16. Furthermore, the most important risk factor for hand and glove contamination of healthcare workers with multidrug-resistant bacteria has been demonstrated to be positive environmental cultures 17. To decrease the frequency and level of contamination of environmental surfaces the Centre for Disease Control and Prevention recommends routine disinfection of medical equipment and environmental surfaces to prevent the spread of potential pathogens through the hospital ward or ICU 18. Improved room cleaning has shown to decrease the risk for MRSA, VRE and C. difficile acquisition. Unfortunately, environmental cleaning is frequently inadequate. Less than 50% of hospital room surfaces are adequately cleaned and disinfected even by environmental services personnel. Environmental services personnel have low wages, are under time pressure to clean rooms quickly with high turn-over rates of patients. Novel materials and cleaning technologies have been developed as ultraviolet germicidal irradiation (UVGI) or hydrogen peroxide vapor (HPV). However, both technologies are expensive and can just be used for terminal cleaning and not during routine daily care 16. Self-disinfecting surfaces may overcome these problems. Once applied antimicrobial surfaces will continuously reduce the bioburden of nosocomial pathogens preventing transmission and decrease HAIs. MVX One of these self-disinfecting products is MVX. MVX contains titanium dioxide which by the use of nanotechnology is now available for use in the health sector. Working as a photocatalyticum it generates, in the presence of light, hydroxy radicals and oxygen radicals for at least five years after coating hospital surfaces (durability test TUV Rheinland). Laboratory tests show that MVX is effective in killing bacteria, viruses and fungi (see attachment 1 for summary test results). The positive results reported on the effects of MVX from laboratory evaluations still have to be confirmed in the clinical setting. After getting the CE-marking Gelderse Vallei Hospital in Ede, the Netherlands, will be the first hospital in Europe to study the efficacy of MVX in the Intensive Care Unit (ICU).\n\nDetailed Description\nIntroduction and background Background The annual epidemiological report and annual report of the EARS-NET of the European Centre for Disease Prevention and Control (ECDC) describes a continuing deteriorating situation in European countries. Antimicrobial resistance is increasing in Escherichia coli and Klebsiella pneumoniae isolates and surveillance data show high percentages of ESBL-positive isolates. Of particular concern is the increased percentage of Klebsiella pneumoniae and other bacterial groups resistant to carbapanems (last line antibiotics). Furthermore, the percentage of methicillin-resistant Staphylococcus aureus is still high and remains a public health priority On any given day 5.7% of the patients in European hospitals has a healthcare-associated infection (HAI) with a prevalence of at least one HAI of 19.5% for patients admitted to Intensive Care Units. HAIs are accountable for at least 37000 attributable deaths with annual financial losses estimated at \u20ac7 billion reflecting 16 million extra days of hospital stay. Each year 4 131 000 patients are affected by approximately 4 544 100 episodes of HAIs. The total number of HAIs in European long-term care facilities (LTCFs) is estimated at 4.2 million per year. 8% to 12% of patients in developed countries is confronted with an adverse event (AE) during their hospital stay leading to (permanent) disability or even dead. As HAIs belong to one of the most important AEs they have a considerable economic impact prolonging hospital length of stay, increase readmission rates and necessitate additional ambulatory care or extra societal costs. The total preventable direct medical costs of AEs in the Netherlands are estimated as 1% of the national health care budget (94.2 billion 2013 - Statistics Netherlands). Environmental cleanliness As antimicrobial resistance is a major and overall deteriorating public health problem international cooperation is necessary. Continued progress is needed to implement and improve programmes for the prevention and control of antimicrobial resistance and HAIs. Environmental cleanliness might be one of the most important initiatives to reduce HAIs. Hospital surfaces are heavily contaminated with bacteria with the highest numbers on surfaces closest to the patients. Bed rails, nurse call buttons, curtains, towel dispensers, door handles, sinks, floors, clinical information stations, medical devices, stethoscopes, staff toilets etc. Actually, general hospital wards and Intensive Care Units are loaded with an abundance of potential pathogens. Surviving days, weeks or even months in the environment. Colonizing patients with bacteria from the hospital environment and getting HAIs or even die. As most ventilator-associated pneumonias (VAPs) are the result of nosocomial microorganisms the environment plays an important role in the acquisition of pathogenic bacteria by contaminating health care workers hands and equipment. Furthermore, ICUs and wards struggle with colonized patients with ESBL-bacteria from sinks eventually leading to dead or outbreaks of group A streptococcus infections from contaminated curtains. As key healthcare-associated pathogens have the capacity to persist for weeks to months on hospital surfaces indirect transmission is a serious threat, especially as antimicrobial resistance increases. Hospitalization in a room in which the previous patient had been colonized or infected with nosocomial pathogens (e.g. MRSA, VRE, multidrug-resistant Acinetobacter, Pseudomonas or C. difficile) has been shown to be a risk factor for colonization of infection with the same pathogen for the next patient. Furthermore, the most important risk factor for hand and glove contamination of healthcare workers with multidrug-resistant bacteria has been demonstrated to be positive environmental cultures. To decrease the frequency and level of contamination of environmental surfaces the Centre for Disease Control and Prevention recommends routine disinfection of medical equipment and environmental surfaces to prevent the spread of potential pathogens through the hospital ward or ICU. Improved room cleaning has shown to decrease the risk for MRSA, VRE and C. difficile acquisition. Unfortunately, environmental cleaning is frequently inadequate. Less than 50% of hospital room surfaces are adequately cleaned and disinfected even by environmental services personnel. Environmental services personnel have low wages, are under time pressure to clean rooms quickly with high turn-over rates of patients. Novel materials and cleaning technologies have been developed as ultraviolet germicidal irradiation (UVGI) or hydrogen peroxide vapor (HPV). However, both technologies are expensive and can just be used for terminal cleaning and not during routine daily care. Self-disinfecting surfaces may overcome these problems. Once applied antimicrobial surfaces will continuously reduce the bioburden of nosocomial pathogens preventing transmission and decrease HAIs. MVX One of these self-disinfecting products is MVX. MVX contains titanium dioxide which by the use of nanotechnology is now available for use in the health sector. Working as a photocatalyticum it generates, in the presence of light, hydroxy radicals and oxygen radicals for at least five years after coating hospital surfaces (durability test TUV Rheinland). Laboratory tests show that MVX is effective in killing bacteria, viruses and fungi. To the best of our knowledge there is just one study who examined the efficacy of titanium dioxide in reducing MRSA contamination in a hospital environment 19. In this cross-sectional observational study two ICU isolation rooms were coated and four beds in a 'Intermediate Care Area' (ICA). However, this study had some serious limitations. As 81% of all the samples (N=698) were taken from untreated surfaces there was a high chance of sampling bias. Especially as just 9% of all the samples were taken from the ICA, containing four of the six coated beds/rooms, against 48% of the ICU and 42% of a general ward. Furthermore, as just 10.6% of the samples were positive (N=74) we can really doubt about the validity of this study by the small sample size. Finally, countries with a low prevalence of MRSA (e.g. the Netherlands) are more interested in the prevalence of Enterobacteriaecae or non-MRSA (potential pathogenic microorganisms) and using a (semi)quantitative method. This makes that the positive results reported on the effects of MVX from laboratory evaluations still have to be confirmed in the clinical setting. After getting the CE-marking Gelderse Vallei Hospital in Ede, the Netherlands, will be the first hospital in Europe to study the efficacy of MVX in the Intensive Care Unit (ICU).",
"endDate": "2016-05-01T00:00:00Z",
"id": "sg:clinicaltrial.NCT02348346",
"keywords": [
"titanium dioxide",
"microbial colonization",
"intensive care unit",
"cleanliness",
"antimicrobial resistance",
"public health problem",
"continued progress",
"prevention",
"control",
"Hai",
"important initiative",
"hospital",
"bacteria",
"high number",
"surface",
"patient",
"rail",
"nurse",
"button",
"curtain",
"dispenser",
"door",
"sink",
"Floor and Floorcoverings",
"clinical information",
"Equipment and Supply",
"stethoscope",
"toilet",
"General Hospital",
"abundance",
"potential pathogen",
"hospital environment",
"Ventilator-Associated Pneumonia",
"microorganism",
"environment",
"important role",
"acquisition",
"pathogenic bacteria",
"health care worker",
"ICU",
"struggle",
"outbreak",
"Streptococcus",
"pathogen",
"capacity",
"transmission",
"serious threat",
"hospitalization",
"room",
"methicillin-resistant Staphylococcus aureus",
"VRE",
"Acinetobacter",
"Pseudomonas",
"C. difficile",
"risk factor",
"colonization",
"infection",
"same pathogen",
"important risk factor",
"hand",
"contamination",
"healthcare worker",
"multidrug-resistant bacteria",
"culture",
"decrease",
"frequency",
"disease control",
"disinfection",
"medical equipment",
"hospital ward",
"cleaning",
"risk",
"hospital room",
"environmental service",
"low wage",
"time pressure",
"novel material",
"technology",
"irradiation",
"hydrogen peroxide",
"terminal",
"antimicrobial",
"product",
"nanotechnology",
"health sector",
"working",
"light",
"radical",
"oxygen radical",
"durability",
"laboratory test",
"killing bacteria",
"virus",
"fungi",
"summary",
"positive result",
"laboratory evaluation",
"clinical setting",
"Netherlands",
"Europe",
"efficacy",
"introduction",
"disease prevention",
"European country",
"Escherichia coli",
"Klebsiella pneumoniae",
"surveillance data",
"isolates",
"particular concern",
"bacterial group",
"last line",
"public health priority",
"healthcare-associated infection",
"prevalence",
"death",
"financial loss",
"episode",
"total number",
"long-term care facility",
"developed country",
"adverse event",
"disability",
"economic impact",
"hospital length",
"readmission rate",
"Ambulatory Care",
"societal cost",
"direct medical cost",
"health care budget",
"bed",
"intermediate",
"serious limitation",
"sample",
"high chance",
"selection bias",
"Patients' Room",
"Reproducibility of Result",
"small sample size",
"country",
"low prevalence",
"pathogenic microorganism",
"quantitative method"
],
"name": "Effect of MVX (Titanium Dioxide) on the Microbial Colonization of Surfaces in an Intensive Care Unit",
"sameAs": [
"https://app.dimensions.ai/details/clinical_trial/NCT02348346"
],
"sdDataset": "clinical_trials",
"sdDatePublished": "2019-03-07T15:25",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "file:///pack/app/us_ct_data_00018.json",
"sponsor": [
{
"id": "https://www.grid.ac/institutes/grid.415351.7",
"type": "Organization"
}
],
"startDate": "2015-03-01T00:00:00Z",
"subjectOf": [
{
"id": "https://doi.org/10.1136/qshc.2007.025924",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012908974"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1743-8977-10-15",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013206274",
"https://doi.org/10.1186/1743-8977-10-15"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jhin.2014.02.013",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014741783"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/srep01413",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025485940",
"https://doi.org/10.1038/srep01413"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1472-6963-14-311",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026236225",
"https://doi.org/10.1186/1472-6963-14-311"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1086/424667",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037144861"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1472-6963-9-27",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042584500",
"https://doi.org/10.1186/1472-6963-9-27"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1086/670223",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051747913"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jhin.2014.04.007",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052482070"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1476-0711-12-39",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053559756",
"https://doi.org/10.1186/1476-0711-12-39"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1086/670219",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1058854013"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3855/jidc.800",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071483435"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1077056786",
"type": "CreativeWork"
}
],
"type": "MedicalStudy",
"url": "https://clinicaltrials.gov/show/NCT02348346"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/clinicaltrial.NCT02348346'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/clinicaltrial.NCT02348346'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/clinicaltrial.NCT02348346'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/clinicaltrial.NCT02348346'
This table displays all metadata directly associated to this object as RDF triples.
207 TRIPLES
16 PREDICATES
171 URIs
151 LITERALS
1 BLANK NODES
Subject | Predicate | Object | |
---|---|---|---|
1 | sg:clinicaltrial.NCT02348346 | schema:about | anzsrc-for:3114 |
2 | ″ | ″ | anzsrc-for:3177 |
3 | ″ | schema:description | Environmental cleanliness As antimicrobial resistance is a major and overall deteriorating public health problem international cooperation is necessary. Continued progress is needed to implement and improve programmes for the prevention and control of antimicrobial resistance and HAIs. Environmental cleanliness might be one of the most important initiatives to reduce HAIs. Hospital surfaces are heavily contaminated with bacteria with the highest numbers on surfaces closest to the patients. Bed rails, nurse call buttons, curtains, towel dispensers, door handles, sinks, floors, clinical information stations, medical devices, stethoscopes, staff toilets etc. Actually, general hospital wards and Intensive Care Units are loaded with an abundance of potential pathogens 8,9,10. Surviving days, weeks or even months in the environment 11. Colonizing patients with bacteria from the hospital environment and getting HAIs or even die. As most ventilator-associated pneumonias (VAPs) are the result of nosocomial microorganisms the environment plays an important role in the acquisition of pathogenic bacteria by contaminating health care workers hands and equipment 12,13. Furthermore, ICUs and wards struggle with colonized patients with ESBL-bacteria from sinks eventually leading to dead or outbreaks of group A streptococcus infections from contaminated curtains 14,15. As key healthcare-associated pathogens have the capacity to persist for weeks to months on hospital surfaces indirect transmission is a serious threat, especially as antimicrobial resistance increases. Hospitalization in a room in which the previous patient had been colonized or infected with nosocomial pathogens (e.g. MRSA, VRE, multidrug-resistant Acinetobacter, Pseudomonas or C. difficile) has been shown to be a risk factor for colonization of infection with the same pathogen for the next patient16. Furthermore, the most important risk factor for hand and glove contamination of healthcare workers with multidrug-resistant bacteria has been demonstrated to be positive environmental cultures 17. To decrease the frequency and level of contamination of environmental surfaces the Centre for Disease Control and Prevention recommends routine disinfection of medical equipment and environmental surfaces to prevent the spread of potential pathogens through the hospital ward or ICU 18. Improved room cleaning has shown to decrease the risk for MRSA, VRE and C. difficile acquisition. Unfortunately, environmental cleaning is frequently inadequate. Less than 50% of hospital room surfaces are adequately cleaned and disinfected even by environmental services personnel. Environmental services personnel have low wages, are under time pressure to clean rooms quickly with high turn-over rates of patients. Novel materials and cleaning technologies have been developed as ultraviolet germicidal irradiation (UVGI) or hydrogen peroxide vapor (HPV). However, both technologies are expensive and can just be used for terminal cleaning and not during routine daily care 16. Self-disinfecting surfaces may overcome these problems. Once applied antimicrobial surfaces will continuously reduce the bioburden of nosocomial pathogens preventing transmission and decrease HAIs. MVX One of these self-disinfecting products is MVX. MVX contains titanium dioxide which by the use of nanotechnology is now available for use in the health sector. Working as a photocatalyticum it generates, in the presence of light, hydroxy radicals and oxygen radicals for at least five years after coating hospital surfaces (durability test TUV Rheinland). Laboratory tests show that MVX is effective in killing bacteria, viruses and fungi (see attachment 1 for summary test results). The positive results reported on the effects of MVX from laboratory evaluations still have to be confirmed in the clinical setting. After getting the CE-marking Gelderse Vallei Hospital in Ede, the Netherlands, will be the first hospital in Europe to study the efficacy of MVX in the Intensive Care Unit (ICU). Detailed Description Introduction and background Background The annual epidemiological report and annual report of the EARS-NET of the European Centre for Disease Prevention and Control (ECDC) describes a continuing deteriorating situation in European countries. Antimicrobial resistance is increasing in Escherichia coli and Klebsiella pneumoniae isolates and surveillance data show high percentages of ESBL-positive isolates. Of particular concern is the increased percentage of Klebsiella pneumoniae and other bacterial groups resistant to carbapanems (last line antibiotics). Furthermore, the percentage of methicillin-resistant Staphylococcus aureus is still high and remains a public health priority On any given day 5.7% of the patients in European hospitals has a healthcare-associated infection (HAI) with a prevalence of at least one HAI of 19.5% for patients admitted to Intensive Care Units. HAIs are accountable for at least 37000 attributable deaths with annual financial losses estimated at €7 billion reflecting 16 million extra days of hospital stay. Each year 4 131 000 patients are affected by approximately 4 544 100 episodes of HAIs. The total number of HAIs in European long-term care facilities (LTCFs) is estimated at 4.2 million per year. 8% to 12% of patients in developed countries is confronted with an adverse event (AE) during their hospital stay leading to (permanent) disability or even dead. As HAIs belong to one of the most important AEs they have a considerable economic impact prolonging hospital length of stay, increase readmission rates and necessitate additional ambulatory care or extra societal costs. The total preventable direct medical costs of AEs in the Netherlands are estimated as 1% of the national health care budget (94.2 billion 2013 - Statistics Netherlands). Environmental cleanliness As antimicrobial resistance is a major and overall deteriorating public health problem international cooperation is necessary. Continued progress is needed to implement and improve programmes for the prevention and control of antimicrobial resistance and HAIs. Environmental cleanliness might be one of the most important initiatives to reduce HAIs. Hospital surfaces are heavily contaminated with bacteria with the highest numbers on surfaces closest to the patients. Bed rails, nurse call buttons, curtains, towel dispensers, door handles, sinks, floors, clinical information stations, medical devices, stethoscopes, staff toilets etc. Actually, general hospital wards and Intensive Care Units are loaded with an abundance of potential pathogens. Surviving days, weeks or even months in the environment. Colonizing patients with bacteria from the hospital environment and getting HAIs or even die. As most ventilator-associated pneumonias (VAPs) are the result of nosocomial microorganisms the environment plays an important role in the acquisition of pathogenic bacteria by contaminating health care workers hands and equipment. Furthermore, ICUs and wards struggle with colonized patients with ESBL-bacteria from sinks eventually leading to dead or outbreaks of group A streptococcus infections from contaminated curtains. As key healthcare-associated pathogens have the capacity to persist for weeks to months on hospital surfaces indirect transmission is a serious threat, especially as antimicrobial resistance increases. Hospitalization in a room in which the previous patient had been colonized or infected with nosocomial pathogens (e.g. MRSA, VRE, multidrug-resistant Acinetobacter, Pseudomonas or C. difficile) has been shown to be a risk factor for colonization of infection with the same pathogen for the next patient. Furthermore, the most important risk factor for hand and glove contamination of healthcare workers with multidrug-resistant bacteria has been demonstrated to be positive environmental cultures. To decrease the frequency and level of contamination of environmental surfaces the Centre for Disease Control and Prevention recommends routine disinfection of medical equipment and environmental surfaces to prevent the spread of potential pathogens through the hospital ward or ICU. Improved room cleaning has shown to decrease the risk for MRSA, VRE and C. difficile acquisition. Unfortunately, environmental cleaning is frequently inadequate. Less than 50% of hospital room surfaces are adequately cleaned and disinfected even by environmental services personnel. Environmental services personnel have low wages, are under time pressure to clean rooms quickly with high turn-over rates of patients. Novel materials and cleaning technologies have been developed as ultraviolet germicidal irradiation (UVGI) or hydrogen peroxide vapor (HPV). However, both technologies are expensive and can just be used for terminal cleaning and not during routine daily care. Self-disinfecting surfaces may overcome these problems. Once applied antimicrobial surfaces will continuously reduce the bioburden of nosocomial pathogens preventing transmission and decrease HAIs. MVX One of these self-disinfecting products is MVX. MVX contains titanium dioxide which by the use of nanotechnology is now available for use in the health sector. Working as a photocatalyticum it generates, in the presence of light, hydroxy radicals and oxygen radicals for at least five years after coating hospital surfaces (durability test TUV Rheinland). Laboratory tests show that MVX is effective in killing bacteria, viruses and fungi. To the best of our knowledge there is just one study who examined the efficacy of titanium dioxide in reducing MRSA contamination in a hospital environment 19. In this cross-sectional observational study two ICU isolation rooms were coated and four beds in a 'Intermediate Care Area' (ICA). However, this study had some serious limitations. As 81% of all the samples (N=698) were taken from untreated surfaces there was a high chance of sampling bias. Especially as just 9% of all the samples were taken from the ICA, containing four of the six coated beds/rooms, against 48% of the ICU and 42% of a general ward. Furthermore, as just 10.6% of the samples were positive (N=74) we can really doubt about the validity of this study by the small sample size. Finally, countries with a low prevalence of MRSA (e.g. the Netherlands) are more interested in the prevalence of Enterobacteriaecae or non-MRSA (potential pathogenic microorganisms) and using a (semi)quantitative method. This makes that the positive results reported on the effects of MVX from laboratory evaluations still have to be confirmed in the clinical setting. After getting the CE-marking Gelderse Vallei Hospital in Ede, the Netherlands, will be the first hospital in Europe to study the efficacy of MVX in the Intensive Care Unit (ICU). |
4 | ″ | schema:endDate | 2016-05-01T00:00:00Z |
5 | ″ | schema:keywords | Acinetobacter |
6 | ″ | ″ | Ambulatory Care |
7 | ″ | ″ | C. difficile |
8 | ″ | ″ | Equipment and Supply |
9 | ″ | ″ | Escherichia coli |
10 | ″ | ″ | Europe |
11 | ″ | ″ | European country |
12 | ″ | ″ | Floor and Floorcoverings |
13 | ″ | ″ | General Hospital |
14 | ″ | ″ | Hai |
15 | ″ | ″ | ICU |
16 | ″ | ″ | Klebsiella pneumoniae |
17 | ″ | ″ | Netherlands |
18 | ″ | ″ | Patients' Room |
19 | ″ | ″ | Pseudomonas |
20 | ″ | ″ | Reproducibility of Result |
21 | ″ | ″ | Streptococcus |
22 | ″ | ″ | VRE |
23 | ″ | ″ | Ventilator-Associated Pneumonia |
24 | ″ | ″ | abundance |
25 | ″ | ″ | acquisition |
26 | ″ | ″ | adverse event |
27 | ″ | ″ | antimicrobial |
28 | ″ | ″ | antimicrobial resistance |
29 | ″ | ″ | bacteria |
30 | ″ | ″ | bacterial group |
31 | ″ | ″ | bed |
32 | ″ | ″ | button |
33 | ″ | ″ | capacity |
34 | ″ | ″ | cleaning |
35 | ″ | ″ | cleanliness |
36 | ″ | ″ | clinical information |
37 | ″ | ″ | clinical setting |
38 | ″ | ″ | colonization |
39 | ″ | ″ | contamination |
40 | ″ | ″ | continued progress |
41 | ″ | ″ | control |
42 | ″ | ″ | country |
43 | ″ | ″ | culture |
44 | ″ | ″ | curtain |
45 | ″ | ″ | death |
46 | ″ | ″ | decrease |
47 | ″ | ″ | developed country |
48 | ″ | ″ | direct medical cost |
49 | ″ | ″ | disability |
50 | ″ | ″ | disease control |
51 | ″ | ″ | disease prevention |
52 | ″ | ″ | disinfection |
53 | ″ | ″ | dispenser |
54 | ″ | ″ | door |
55 | ″ | ″ | durability |
56 | ″ | ″ | economic impact |
57 | ″ | ″ | efficacy |
58 | ″ | ″ | environment |
59 | ″ | ″ | environmental service |
60 | ″ | ″ | episode |
61 | ″ | ″ | financial loss |
62 | ″ | ″ | frequency |
63 | ″ | ″ | fungi |
64 | ″ | ″ | hand |
65 | ″ | ″ | health care budget |
66 | ″ | ″ | health care worker |
67 | ″ | ″ | health sector |
68 | ″ | ″ | healthcare worker |
69 | ″ | ″ | healthcare-associated infection |
70 | ″ | ″ | high chance |
71 | ″ | ″ | high number |
72 | ″ | ″ | hospital |
73 | ″ | ″ | hospital environment |
74 | ″ | ″ | hospital length |
75 | ″ | ″ | hospital room |
76 | ″ | ″ | hospital ward |
77 | ″ | ″ | hospitalization |
78 | ″ | ″ | hydrogen peroxide |
79 | ″ | ″ | important initiative |
80 | ″ | ″ | important risk factor |
81 | ″ | ″ | important role |
82 | ″ | ″ | infection |
83 | ″ | ″ | intensive care unit |
84 | ″ | ″ | intermediate |
85 | ″ | ″ | introduction |
86 | ″ | ″ | irradiation |
87 | ″ | ″ | isolates |
88 | ″ | ″ | killing bacteria |
89 | ″ | ″ | laboratory evaluation |
90 | ″ | ″ | laboratory test |
91 | ″ | ″ | last line |
92 | ″ | ″ | light |
93 | ″ | ″ | long-term care facility |
94 | ″ | ″ | low prevalence |
95 | ″ | ″ | low wage |
96 | ″ | ″ | medical equipment |
97 | ″ | ″ | methicillin-resistant Staphylococcus aureus |
98 | ″ | ″ | microbial colonization |
99 | ″ | ″ | microorganism |
100 | ″ | ″ | multidrug-resistant bacteria |
101 | ″ | ″ | nanotechnology |
102 | ″ | ″ | novel material |
103 | ″ | ″ | nurse |
104 | ″ | ″ | outbreak |
105 | ″ | ″ | oxygen radical |
106 | ″ | ″ | particular concern |
107 | ″ | ″ | pathogen |
108 | ″ | ″ | pathogenic bacteria |
109 | ″ | ″ | pathogenic microorganism |
110 | ″ | ″ | patient |
111 | ″ | ″ | positive result |
112 | ″ | ″ | potential pathogen |
113 | ″ | ″ | prevalence |
114 | ″ | ″ | prevention |
115 | ″ | ″ | product |
116 | ″ | ″ | public health priority |
117 | ″ | ″ | public health problem |
118 | ″ | ″ | quantitative method |
119 | ″ | ″ | radical |
120 | ″ | ″ | rail |
121 | ″ | ″ | readmission rate |
122 | ″ | ″ | risk |
123 | ″ | ″ | risk factor |
124 | ″ | ″ | room |
125 | ″ | ″ | same pathogen |
126 | ″ | ″ | sample |
127 | ″ | ″ | selection bias |
128 | ″ | ″ | serious limitation |
129 | ″ | ″ | serious threat |
130 | ″ | ″ | sink |
131 | ″ | ″ | small sample size |
132 | ″ | ″ | societal cost |
133 | ″ | ″ | stethoscope |
134 | ″ | ″ | struggle |
135 | ″ | ″ | summary |
136 | ″ | ″ | surface |
137 | ″ | ″ | surveillance data |
138 | ″ | ″ | technology |
139 | ″ | ″ | terminal |
140 | ″ | ″ | time pressure |
141 | ″ | ″ | titanium dioxide |
142 | ″ | ″ | toilet |
143 | ″ | ″ | total number |
144 | ″ | ″ | transmission |
145 | ″ | ″ | virus |
146 | ″ | ″ | working |
147 | ″ | schema:name | Effect of MVX (Titanium Dioxide) on the Microbial Colonization of Surfaces in an Intensive Care Unit |
148 | ″ | schema:sameAs | https://app.dimensions.ai/details/clinical_trial/NCT02348346 |
149 | ″ | schema:sdDatePublished | 2019-03-07T15:25 |
150 | ″ | schema:sdLicense | https://scigraph.springernature.com/explorer/license/ |
151 | ″ | schema:sdPublisher | N163d070c7ce04e0f8e2afd5832061f0c |
152 | ″ | schema:sponsor | https://www.grid.ac/institutes/grid.415351.7 |
153 | ″ | schema:startDate | 2015-03-01T00:00:00Z |
154 | ″ | schema:subjectOf | sg:pub.10.1038/srep01413 |
155 | ″ | ″ | sg:pub.10.1186/1472-6963-14-311 |
156 | ″ | ″ | sg:pub.10.1186/1472-6963-9-27 |
157 | ″ | ″ | sg:pub.10.1186/1476-0711-12-39 |
158 | ″ | ″ | sg:pub.10.1186/1743-8977-10-15 |
159 | ″ | ″ | https://app.dimensions.ai/details/publication/pub.1077056786 |
160 | ″ | ″ | https://doi.org/10.1016/j.jhin.2014.02.013 |
161 | ″ | ″ | https://doi.org/10.1016/j.jhin.2014.04.007 |
162 | ″ | ″ | https://doi.org/10.1086/424667 |
163 | ″ | ″ | https://doi.org/10.1086/670219 |
164 | ″ | ″ | https://doi.org/10.1086/670223 |
165 | ″ | ″ | https://doi.org/10.1136/qshc.2007.025924 |
166 | ″ | ″ | https://doi.org/10.3855/jidc.800 |
167 | ″ | schema:url | https://clinicaltrials.gov/show/NCT02348346 |
168 | ″ | sgo:license | sg:explorer/license/ |
169 | ″ | sgo:sdDataset | clinical_trials |
170 | ″ | rdf:type | schema:MedicalStudy |
171 | N163d070c7ce04e0f8e2afd5832061f0c | schema:name | Springer Nature - SN SciGraph project |
172 | ″ | rdf:type | schema:Organization |
173 | anzsrc-for:3114 | schema:inDefinedTermSet | anzsrc-for: |
174 | ″ | rdf:type | schema:DefinedTerm |
175 | anzsrc-for:3177 | schema:inDefinedTermSet | anzsrc-for: |
176 | ″ | rdf:type | schema:DefinedTerm |
177 | sg:pub.10.1038/srep01413 | schema:sameAs | https://app.dimensions.ai/details/publication/pub.1025485940 |
178 | ″ | ″ | https://doi.org/10.1038/srep01413 |
179 | ″ | rdf:type | schema:CreativeWork |
180 | sg:pub.10.1186/1472-6963-14-311 | schema:sameAs | https://app.dimensions.ai/details/publication/pub.1026236225 |
181 | ″ | ″ | https://doi.org/10.1186/1472-6963-14-311 |
182 | ″ | rdf:type | schema:CreativeWork |
183 | sg:pub.10.1186/1472-6963-9-27 | schema:sameAs | https://app.dimensions.ai/details/publication/pub.1042584500 |
184 | ″ | ″ | https://doi.org/10.1186/1472-6963-9-27 |
185 | ″ | rdf:type | schema:CreativeWork |
186 | sg:pub.10.1186/1476-0711-12-39 | schema:sameAs | https://app.dimensions.ai/details/publication/pub.1053559756 |
187 | ″ | ″ | https://doi.org/10.1186/1476-0711-12-39 |
188 | ″ | rdf:type | schema:CreativeWork |
189 | sg:pub.10.1186/1743-8977-10-15 | schema:sameAs | https://app.dimensions.ai/details/publication/pub.1013206274 |
190 | ″ | ″ | https://doi.org/10.1186/1743-8977-10-15 |
191 | ″ | rdf:type | schema:CreativeWork |
192 | https://app.dimensions.ai/details/publication/pub.1077056786 | ″ | schema:CreativeWork |
193 | https://doi.org/10.1016/j.jhin.2014.02.013 | schema:sameAs | https://app.dimensions.ai/details/publication/pub.1014741783 |
194 | ″ | rdf:type | schema:CreativeWork |
195 | https://doi.org/10.1016/j.jhin.2014.04.007 | schema:sameAs | https://app.dimensions.ai/details/publication/pub.1052482070 |
196 | ″ | rdf:type | schema:CreativeWork |
197 | https://doi.org/10.1086/424667 | schema:sameAs | https://app.dimensions.ai/details/publication/pub.1037144861 |
198 | ″ | rdf:type | schema:CreativeWork |
199 | https://doi.org/10.1086/670219 | schema:sameAs | https://app.dimensions.ai/details/publication/pub.1058854013 |
200 | ″ | rdf:type | schema:CreativeWork |
201 | https://doi.org/10.1086/670223 | schema:sameAs | https://app.dimensions.ai/details/publication/pub.1051747913 |
202 | ″ | rdf:type | schema:CreativeWork |
203 | https://doi.org/10.1136/qshc.2007.025924 | schema:sameAs | https://app.dimensions.ai/details/publication/pub.1012908974 |
204 | ″ | rdf:type | schema:CreativeWork |
205 | https://doi.org/10.3855/jidc.800 | schema:sameAs | https://app.dimensions.ai/details/publication/pub.1071483435 |
206 | ″ | rdf:type | schema:CreativeWork |
207 | https://www.grid.ac/institutes/grid.415351.7 | ″ | schema:Organization |