Molecular Profiling of Stage II and III Breast Cancer in Latin American Women Receiving Standard-of-Care Treatment View Homepage


Ontology type: schema:MedicalStudy     


Clinical Trial Info

YEARS

2014-2018

ABSTRACT

Background: - Researchers want to learn more about breast cancer in Latin American women. They also want to learn how and why women respond differently to standard treatment. Tissue and blood samples from women with breast cancer are needed to study this disease in order to find new ways to prevent, diagnose, and treat it. Objective: - To learn more about the biology and genetics of breast cancer in Latin American women. Eligibility: - Latin American women age 18 and older of all ethnic backgrounds who have clinical stage II or III breast cancer. They must still be active and able to self-care. Design: - Participants are only agreeing to have extra tissue or blood samples collected. They are also letting tissue left over from surgery be used for research. No procedures outside of standard care will be done. - Participants may have a medical history, physical exam, and blood tests. They may have a pregnancy test. They may have an ultrasound, mammogram, and other scans. They may have an intravenous needle placed in an arm vein. - Participants may have a core biopsy. For this, a needle is inserted into the breast. A piece of tissue is extracted. - Participants who have chemotherapy may have blood taken after treatment/before surgery. Tissue may also be collected. - Participants will complete a questionnaire. It will ask about their social and economic background. It will ask about their family history of cancer. It will also ask about access to diagnosis and treatment of breast cancer. - Participants may be followed for up to 5 years. Detailed Description The primary objective of this study is to characterize the distribution of molecular profiles in Latin American women with AJCC 7 clinical stage II or III breast cancer. The molecular profiles will be correlated with epidemiological, histological, and clinical characteristics, including pathologic response to standard neoadjuvant chemotherapy. Moreover, this study intends to define a molecular signature that will predict response to neoadjuvant therapy in breast cancer. This is a prospective cohort study in which no investigational drugs will be administered to participants. The study will be conducted at participating institutions in Argentina, Brazil, Chile, Mexico, and Uruguay. More... »

URL

https://clinicaltrials.gov/show/NCT02326857

Related SciGraph Publications

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/3142", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }
    ], 
    "description": "Background: - Researchers want to learn more about breast cancer in Latin American women. They also want to learn how and why women respond differently to standard treatment. Tissue and blood samples from women with breast cancer are needed to study this disease in order to find new ways to prevent, diagnose, and treat it. Objective: - To learn more about the biology and genetics of breast cancer in Latin American women. Eligibility: - Latin American women age 18 and older of all ethnic backgrounds who have clinical stage II or III breast cancer. They must still be active and able to self-care. Design: - Participants are only agreeing to have extra tissue or blood samples collected. They are also letting tissue left over from surgery be used for research. No procedures outside of standard care will be done. - Participants may have a medical history, physical exam, and blood tests. They may have a pregnancy test. They may have an ultrasound, mammogram, and other scans. They may have an intravenous needle placed in an arm vein. - Participants may have a core biopsy. For this, a needle is inserted into the breast. A piece of tissue is extracted. - Participants who have chemotherapy may have blood taken after treatment/before surgery. Tissue may also be collected. - Participants will complete a questionnaire. It will ask about their social and economic background. It will ask about their family history of cancer. It will also ask about access to diagnosis and treatment of breast cancer. - Participants may be followed for up to 5 years.\n\nDetailed Description\nThe primary objective of this study is to characterize the distribution of molecular profiles in Latin American women with AJCC 7 clinical stage II or III breast cancer. The molecular profiles will be correlated with epidemiological, histological, and clinical characteristics, including pathologic response to standard neoadjuvant chemotherapy. Moreover, this study intends to define a molecular signature that will predict response to neoadjuvant therapy in breast cancer. This is a prospective cohort study in which no investigational drugs will be administered to participants. The study will be conducted at participating institutions in Argentina, Brazil, Chile, Mexico, and Uruguay.", 
    "endDate": "2018-12-01T00:00:00Z", 
    "id": "sg:clinicaltrial.NCT02326857", 
    "keywords": [
      "molecular profiling", 
      "standard-of-care", 
      "Breast Neoplasm", 
      "Latin American", 
      "woman", 
      "standard treatment", 
      "tissue", 
      "blood sample", 
      "disease", 
      "diagnose", 
      "biology", 
      "genetics", 
      "eligibility", 
      "ethnic background", 
      "clinical stage", 
      "Self Care", 
      "General Surgery", 
      "method", 
      "standard care", 
      "medical history", 
      "physical exam", 
      "Hematologic Test", 
      "pregnancy", 
      "ultrasound", 
      "mammogram", 
      "needle", 
      "vein", 
      "core biopsy", 
      "breast", 
      "piece", 
      "Drug Therapy", 
      "blood", 
      "questionnaire", 
      "Economics", 
      "family history", 
      "Neoplasm", 
      "access", 
      "diagnosis", 
      "primary objective", 
      "distribution", 
      "molecular profile", 
      "clinical characteristic", 
      "pathologic response", 
      "neoadjuvant chemotherapy", 
      "molecular signature", 
      "neoadjuvant therapy", 
      "prospective cohort study", 
      "investigational drug", 
      "institution", 
      "Argentina", 
      "Brazil", 
      "Chile", 
      "Mexico", 
      "Uruguay"
    ], 
    "name": "Molecular Profiling of Stage II and III Breast Cancer in Latin American Women Receiving Standard-of-Care Treatment", 
    "sameAs": [
      "https://app.dimensions.ai/details/clinical_trial/NCT02326857"
    ], 
    "sdDataset": "clinical_trials", 
    "sdDatePublished": "2019-03-07T15:25", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "file:///pack/app/us_ct_data_00018.json", 
    "sponsor": [
      {
        "id": "https://www.grid.ac/institutes/grid.48336.3a", 
        "type": "Organization"
      }, 
      {
        "id": "https://www.grid.ac/institutes/grid.410305.3", 
        "type": "Organization"
      }, 
      {
        "id": "https://www.grid.ac/institutes/grid.418081.4", 
        "type": "Organization"
      }, 
      {
        "id": "https://www.grid.ac/institutes/grid.488966.d", 
        "type": "Organization"
      }, 
      {
        "id": "https://www.grid.ac/institutes/grid.415779.9", 
        "type": "Organization"
      }, 
      {
        "id": "https://www.grid.ac/institutes/grid.11893.32", 
        "type": "Organization"
      }, 
      {
        "id": "https://www.grid.ac/institutes/grid.412890.6", 
        "type": "Organization"
      }, 
      {
        "id": "https://www.grid.ac/institutes/grid.419166.d", 
        "type": "Organization"
      }
    ], 
    "startDate": "2014-12-01T00:00:00Z", 
    "subjectOf": [
      {
        "id": "sg:pub.10.1038/35021093", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033846543", 
          "https://doi.org/10.1038/35021093"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.02.6914", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045440787"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/jwh.2008.1127", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059291122"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "type": "MedicalStudy", 
    "url": "https://clinicaltrials.gov/show/NCT02326857"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/clinicaltrial.NCT02326857'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/clinicaltrial.NCT02326857'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/clinicaltrial.NCT02326857'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/clinicaltrial.NCT02326857'


 

This table displays all metadata directly associated to this object as RDF triples.

97 TRIPLES      16 PREDICATES      79 URIs      63 LITERALS      1 BLANK NODES

Subject Predicate Object
1 sg:clinicaltrial.NCT02326857 schema:about anzsrc-for:3142
2 schema:description Background: - Researchers want to learn more about breast cancer in Latin American women. They also want to learn how and why women respond differently to standard treatment. Tissue and blood samples from women with breast cancer are needed to study this disease in order to find new ways to prevent, diagnose, and treat it. Objective: - To learn more about the biology and genetics of breast cancer in Latin American women. Eligibility: - Latin American women age 18 and older of all ethnic backgrounds who have clinical stage II or III breast cancer. They must still be active and able to self-care. Design: - Participants are only agreeing to have extra tissue or blood samples collected. They are also letting tissue left over from surgery be used for research. No procedures outside of standard care will be done. - Participants may have a medical history, physical exam, and blood tests. They may have a pregnancy test. They may have an ultrasound, mammogram, and other scans. They may have an intravenous needle placed in an arm vein. - Participants may have a core biopsy. For this, a needle is inserted into the breast. A piece of tissue is extracted. - Participants who have chemotherapy may have blood taken after treatment/before surgery. Tissue may also be collected. - Participants will complete a questionnaire. It will ask about their social and economic background. It will ask about their family history of cancer. It will also ask about access to diagnosis and treatment of breast cancer. - Participants may be followed for up to 5 years. Detailed Description The primary objective of this study is to characterize the distribution of molecular profiles in Latin American women with AJCC 7 clinical stage II or III breast cancer. The molecular profiles will be correlated with epidemiological, histological, and clinical characteristics, including pathologic response to standard neoadjuvant chemotherapy. Moreover, this study intends to define a molecular signature that will predict response to neoadjuvant therapy in breast cancer. This is a prospective cohort study in which no investigational drugs will be administered to participants. The study will be conducted at participating institutions in Argentina, Brazil, Chile, Mexico, and Uruguay.
3 schema:endDate 2018-12-01T00:00:00Z
4 schema:keywords Argentina
5 Brazil
6 Breast Neoplasm
7 Chile
8 Drug Therapy
9 Economics
10 General Surgery
11 Hematologic Test
12 Latin American
13 Mexico
14 Neoplasm
15 Self Care
16 Uruguay
17 access
18 biology
19 blood
20 blood sample
21 breast
22 clinical characteristic
23 clinical stage
24 core biopsy
25 diagnose
26 diagnosis
27 disease
28 distribution
29 eligibility
30 ethnic background
31 family history
32 genetics
33 institution
34 investigational drug
35 mammogram
36 medical history
37 method
38 molecular profile
39 molecular profiling
40 molecular signature
41 needle
42 neoadjuvant chemotherapy
43 neoadjuvant therapy
44 pathologic response
45 physical exam
46 piece
47 pregnancy
48 primary objective
49 prospective cohort study
50 questionnaire
51 standard care
52 standard treatment
53 standard-of-care
54 tissue
55 ultrasound
56 vein
57 woman
58 schema:name Molecular Profiling of Stage II and III Breast Cancer in Latin American Women Receiving Standard-of-Care Treatment
59 schema:sameAs https://app.dimensions.ai/details/clinical_trial/NCT02326857
60 schema:sdDatePublished 2019-03-07T15:25
61 schema:sdLicense https://scigraph.springernature.com/explorer/license/
62 schema:sdPublisher N09fcd3e356aa424aacb0a8739ff92837
63 schema:sponsor https://www.grid.ac/institutes/grid.11893.32
64 https://www.grid.ac/institutes/grid.410305.3
65 https://www.grid.ac/institutes/grid.412890.6
66 https://www.grid.ac/institutes/grid.415779.9
67 https://www.grid.ac/institutes/grid.418081.4
68 https://www.grid.ac/institutes/grid.419166.d
69 https://www.grid.ac/institutes/grid.48336.3a
70 https://www.grid.ac/institutes/grid.488966.d
71 schema:startDate 2014-12-01T00:00:00Z
72 schema:subjectOf sg:pub.10.1038/35021093
73 https://doi.org/10.1089/jwh.2008.1127
74 https://doi.org/10.1200/jco.2005.02.6914
75 schema:url https://clinicaltrials.gov/show/NCT02326857
76 sgo:license sg:explorer/license/
77 sgo:sdDataset clinical_trials
78 rdf:type schema:MedicalStudy
79 N09fcd3e356aa424aacb0a8739ff92837 schema:name Springer Nature - SN SciGraph project
80 rdf:type schema:Organization
81 anzsrc-for:3142 schema:inDefinedTermSet anzsrc-for:
82 rdf:type schema:DefinedTerm
83 sg:pub.10.1038/35021093 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033846543
84 https://doi.org/10.1038/35021093
85 rdf:type schema:CreativeWork
86 https://doi.org/10.1089/jwh.2008.1127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059291122
87 rdf:type schema:CreativeWork
88 https://doi.org/10.1200/jco.2005.02.6914 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045440787
89 rdf:type schema:CreativeWork
90 https://www.grid.ac/institutes/grid.11893.32 schema:Organization
91 https://www.grid.ac/institutes/grid.410305.3 schema:Organization
92 https://www.grid.ac/institutes/grid.412890.6 schema:Organization
93 https://www.grid.ac/institutes/grid.415779.9 schema:Organization
94 https://www.grid.ac/institutes/grid.418081.4 schema:Organization
95 https://www.grid.ac/institutes/grid.419166.d schema:Organization
96 https://www.grid.ac/institutes/grid.48336.3a schema:Organization
97 https://www.grid.ac/institutes/grid.488966.d schema:Organization
 




Preview window. Press ESC to close (or click here)


...